Metallothionein synthesis increased by Ninjin-yoei-to, a Kampo medicine protects neuronal death and memory loss after exposure to amyloid β1-42

Metallothionein synthesis increased by Ninjin-yoei-to, a Kampo medicine protects neuronal death and memory loss after exposure to amyloid β1-42

Abstract Background It is possible that increased synthesis of metallothioneins (MTs), Zn2+-binding proteins is linked with the protective effect of Ninjin-yoei-to (NYT) on Zn2+ toxicity ferried by amyloid β1-42 (Aβ1-42). Methods Judging from the biological half-life (18-20 h) of MTs, the effective...

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Bibliographic Details
Main Authors: Haruna Tamano, Haruna Tokoro, Daichi Murakami, Rin Tsujimoto, Yuka Nishijima, Erina Tsuda, Satoshi Watanabe, Miki Suzuki, Atsushi Takeda
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Journal of Pharmaceutical Health Care and Sciences
Subjects:
Metallothionein
Amyloid β1-42
Alzheimer’s disease
Zn2+ dysregulation
Ninjin-yoei-to
Kampo medicine
Online Access:https://doi.org/10.1186/s40780-022-00257-8

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