Determination of the Molecular Parameters of Heterologous Anti-Rabies Immunoglobulin Using Gel-Filtration
Presented are the data of analysis of molecular parameters of heterologous immunoglobulin produced by the Russian Research Anti-Plague Institute "Microbe". It is noted that the optimal system of rectification enables to obtain a preparation composed of 100 % fraction of monomers. The fract...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”
2010-08-01
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| Series: | Проблемы особо опасных инфекций |
| Subjects: | |
| Online Access: | https://journal.microbe.ru/jour/article/view/566 |
| _version_ | 1797220990485266432 |
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| author | E. G. Abramova A. K. Nikiforov M. N. Kireev N. N. Kochkalova S. V. Generalov A. G. Selezneva L. V. Savitskaya Yu. V. Ivanov |
| author_facet | E. G. Abramova A. K. Nikiforov M. N. Kireev N. N. Kochkalova S. V. Generalov A. G. Selezneva L. V. Savitskaya Yu. V. Ivanov |
| author_sort | E. G. Abramova |
| collection | DOAJ |
| description | Presented are the data of analysis of molecular parameters of heterologous immunoglobulin produced by the Russian Research Anti-Plague Institute "Microbe". It is noted that the optimal system of rectification enables to obtain a preparation composed of 100 % fraction of monomers. The fraction of fragments appears in the process of immunoglobulin storage, however its content is insignificant. The fraction of aggregates is not registered at the date of preparation delivery nor after its storage during 5 years. Lyophilized preparation is determined to be advantageous in comparison with the liquid one as regards molecular parameters integrity. |
| first_indexed | 2024-03-08T13:44:07Z |
| format | Article |
| id | doaj.art-17374476976d47e8915f62fd40e4888e |
| institution | Directory Open Access Journal |
| issn | 0370-1069 2658-719X |
| language | Russian |
| last_indexed | 2024-04-24T12:58:19Z |
| publishDate | 2010-08-01 |
| publisher | Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” |
| record_format | Article |
| series | Проблемы особо опасных инфекций |
| spelling | doaj.art-17374476976d47e8915f62fd40e4888e2024-04-05T16:47:06ZrusFederal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”Проблемы особо опасных инфекций0370-10692658-719X2010-08-0104(106)545710.21055/0370-1069-2010-4(106)-54-57550Determination of the Molecular Parameters of Heterologous Anti-Rabies Immunoglobulin Using Gel-FiltrationE. G. Abramova0A. K. Nikiforov1M. N. Kireev2N. N. Kochkalova3S. V. Generalov4A. G. Selezneva5L. V. Savitskaya6Yu. V. Ivanov7Russian Research Anti-Plague Institute MicrobeRussian Research Anti-Plague Institute MicrobeRussian Research Anti-Plague Institute MicrobeRussian Research Anti-Plague Institute MicrobeRussian Research Anti-Plague Institute MicrobeRussian Research Anti-Plague Institute MicrobeRussian Research Anti-Plague Institute MicrobeRussian Research Anti-Plague Institute MicrobePresented are the data of analysis of molecular parameters of heterologous immunoglobulin produced by the Russian Research Anti-Plague Institute "Microbe". It is noted that the optimal system of rectification enables to obtain a preparation composed of 100 % fraction of monomers. The fraction of fragments appears in the process of immunoglobulin storage, however its content is insignificant. The fraction of aggregates is not registered at the date of preparation delivery nor after its storage during 5 years. Lyophilized preparation is determined to be advantageous in comparison with the liquid one as regards molecular parameters integrity.https://journal.microbe.ru/jour/article/view/566anti-rabies immunoglobulinfragmentationaggregationgel-filtration |
| spellingShingle | E. G. Abramova A. K. Nikiforov M. N. Kireev N. N. Kochkalova S. V. Generalov A. G. Selezneva L. V. Savitskaya Yu. V. Ivanov Determination of the Molecular Parameters of Heterologous Anti-Rabies Immunoglobulin Using Gel-Filtration Проблемы особо опасных инфекций anti-rabies immunoglobulin fragmentation aggregation gel-filtration |
| title | Determination of the Molecular Parameters of Heterologous Anti-Rabies Immunoglobulin Using Gel-Filtration |
| title_full | Determination of the Molecular Parameters of Heterologous Anti-Rabies Immunoglobulin Using Gel-Filtration |
| title_fullStr | Determination of the Molecular Parameters of Heterologous Anti-Rabies Immunoglobulin Using Gel-Filtration |
| title_full_unstemmed | Determination of the Molecular Parameters of Heterologous Anti-Rabies Immunoglobulin Using Gel-Filtration |
| title_short | Determination of the Molecular Parameters of Heterologous Anti-Rabies Immunoglobulin Using Gel-Filtration |
| title_sort | determination of the molecular parameters of heterologous anti rabies immunoglobulin using gel filtration |
| topic | anti-rabies immunoglobulin fragmentation aggregation gel-filtration |
| url | https://journal.microbe.ru/jour/article/view/566 |
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