Induced Heteroresistance in Carbapenem-Resistant <i>Acinetobacter baumannii</i> (CRAB) via Exposure to Human Pleural Fluid (HPF) and Its Impact on Cefiderocol Susceptibility

Induced Heteroresistance in Carbapenem-Resistant <i>Acinetobacter baumannii</i> (CRAB) via Exposure to Human Pleural Fluid (HPF) and Its Impact on Cefiderocol Susceptibility

Infections caused by Carbapenem-resistant <i>Acinetobacter baumannii</i> (CRAB) isolates, such as hospital-acquired pneumonia (HAP), bacteremia, and skin and soft tissue infections, among others, are particularly challenging to treat. Cefiderocol, a chlorocatechol-substituted siderophore...

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Bibliographic Details
Main Authors: Vyanka Mezcord, Jenny Escalante, Brent Nishimura, German M. Traglia, Rajnikant Sharma, Quentin Vallé, Marisel R. Tuttobene, Tomás Subils, Ingrid Marin, Fernando Pasteran, Luis A. Actis, Marcelo E. Tolmasky, Robert A. Bonomo, Gauri Rao, María S. Ramirez
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Acinetobacter baumannii</i>
human pleural fluid
cefiderocol
NDM-1
carbapenem-resistance
whole-genome sequencing
Online Access:https://www.mdpi.com/1422-0067/24/14/11752

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