Global Disruption of α2A Adrenoceptor Barely Affects Bone Tissue but Minimizes the Detrimental Effects of Thyrotoxicosis on Cortical Bone

Global Disruption of α2A Adrenoceptor Barely Affects Bone Tissue but Minimizes the Detrimental Effects of Thyrotoxicosis on Cortical Bone

Evidence shows that sympathetic nervous system (SNS) activation inhibits bone formation and activates bone resorption leading to bone loss. Because thyroid hormone (TH) interacts with the SNS to control several physiological processes, we raised the hypothesis that this interaction also controls bon...

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Bibliographic Details
Main Authors: Gisele M. Martins, Marília B. C. G. Teixeira, Marcos V. Silva, Bianca Neofiti-Papi, Manuela Miranda-Rodrigues, Patricia C. Brum, Cecilia H. A. Gouveia
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Endocrinology
Subjects:
thyroid hormone
thyrotoxicosis
sympathetic nervous system
α2A-adrenoceptor
cortical bone
trabecular bone
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00486/full

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