Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1
Satellite RNAs are aberrantly transcribed during pancreatic cancer progression. Here, the authors show that major satellite RNA binds to the multifunctional protein YBX1 in the cytoplasm and induces mutations in nuclear and mitochondrial DNA by preventing YBX1 stress-induced intracellular translocat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2016-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13006 |
| _version_ | 1818716820802109440 |
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| author | Takahiro Kishikawa Motoyuki Otsuka Takeshi Yoshikawa Motoko Ohno Hideaki Ijichi Kazuhiko Koike |
| author_facet | Takahiro Kishikawa Motoyuki Otsuka Takeshi Yoshikawa Motoko Ohno Hideaki Ijichi Kazuhiko Koike |
| author_sort | Takahiro Kishikawa |
| collection | DOAJ |
| description | Satellite RNAs are aberrantly transcribed during pancreatic cancer progression. Here, the authors show that major satellite RNA binds to the multifunctional protein YBX1 in the cytoplasm and induces mutations in nuclear and mitochondrial DNA by preventing YBX1 stress-induced intracellular translocation. |
| first_indexed | 2024-12-17T19:25:20Z |
| format | Article |
| id | doaj.art-173d08df061945b9a821dd66d44d0e58 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T19:25:20Z |
| publishDate | 2016-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-173d08df061945b9a821dd66d44d0e582022-12-21T21:35:23ZengNature PortfolioNature Communications2041-17232016-09-017111210.1038/ncomms13006Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1Takahiro Kishikawa0Motoyuki Otsuka1Takeshi Yoshikawa2Motoko Ohno3Hideaki Ijichi4Kazuhiko Koike5Department of Gastroenterology, Graduate School of Medicine, The University of TokyoDepartment of Gastroenterology, Graduate School of Medicine, The University of TokyoDepartment of Gastroenterology, Graduate School of Medicine, The University of TokyoDepartment of Gastroenterology, Graduate School of Medicine, The University of TokyoDepartment of Gastroenterology, Graduate School of Medicine, The University of TokyoDepartment of Gastroenterology, Graduate School of Medicine, The University of TokyoSatellite RNAs are aberrantly transcribed during pancreatic cancer progression. Here, the authors show that major satellite RNA binds to the multifunctional protein YBX1 in the cytoplasm and induces mutations in nuclear and mitochondrial DNA by preventing YBX1 stress-induced intracellular translocation.https://doi.org/10.1038/ncomms13006 |
| spellingShingle | Takahiro Kishikawa Motoyuki Otsuka Takeshi Yoshikawa Motoko Ohno Hideaki Ijichi Kazuhiko Koike Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1 Nature Communications |
| title | Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1 |
| title_full | Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1 |
| title_fullStr | Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1 |
| title_full_unstemmed | Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1 |
| title_short | Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1 |
| title_sort | satellite rnas promote pancreatic oncogenic processes via the dysfunction of ybx1 |
| url | https://doi.org/10.1038/ncomms13006 |
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