RENAL CLEARANCE AND URINARY EXCRETION OF CIPROFLOXACIN IN GOATS
The renal clearance and urinary excretion of ciprofloxacin were investigated in eight healthy female goats. In each animal, ciprofloxacin was administered intramuscularly at the rate of 5 mg/kg body weight. Following drug administration, blood and urine samples were collected at different time inter...
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| Format: | Article |
| Language: | English |
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University of Agriculture, Faisalabad
2007-10-01
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| Series: | Pakistan Veterinary Journal |
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| Online Access: | http://pvj.com.pk/pdf-files/27_4/179-183.pdf |
| _version_ | 1819130696560541696 |
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| author | Z. IQBAL, I. JAVED, B. ASLAM, F. MUHAMMAD AND I. U. JAN |
| author_facet | Z. IQBAL, I. JAVED, B. ASLAM, F. MUHAMMAD AND I. U. JAN |
| author_sort | Z. IQBAL, I. JAVED, B. ASLAM, F. MUHAMMAD AND I. U. JAN |
| collection | DOAJ |
| description | The renal clearance and urinary excretion of ciprofloxacin were investigated in eight healthy female goats. In each animal, ciprofloxacin was administered intramuscularly at the rate of 5 mg/kg body weight. Following drug administration, blood and urine samples were collected at different time intervals and analyzed for ciprofloxacin and creatinine. High performance liquid chromatography (HPLC) was used to determine the drug concentration in the plasma and urine. The value of diuresis after single administration of ciprofloxacin was 0.073 ± 0.014 ml/min/kg. Mean (± SE) values for renal clearance of creatinine and ciprofloxacin were 1.870 ± 0.385 and 0.982 ± 0.166 ml/min/kg, respectively. The ratio between the renal clearance of ciprofloxacin and that of creatinine remained less than one, which was indicative of back diffusion. The mean (± SE) value for the cumulative percent of ciprofloxacin dose excreted at 10 hours following its intramuscular administration was 13.03 ± 2.07. Based on these results, it was evident that besides glomerular filtration, renal handling of drug involved back diffusion also. It was concluded that in local goats glomerular filtration rate (GFR) was lower than that reported for their foreign counterparts. |
| first_indexed | 2024-12-22T09:03:43Z |
| format | Article |
| id | doaj.art-173ef5f031a6468fa341b8bc5ad2c223 |
| institution | Directory Open Access Journal |
| issn | 0253-8318 |
| language | English |
| last_indexed | 2024-12-22T09:03:43Z |
| publishDate | 2007-10-01 |
| publisher | University of Agriculture, Faisalabad |
| record_format | Article |
| series | Pakistan Veterinary Journal |
| spelling | doaj.art-173ef5f031a6468fa341b8bc5ad2c2232022-12-21T18:31:39ZengUniversity of Agriculture, FaisalabadPakistan Veterinary Journal0253-83182007-10-01274179183RENAL CLEARANCE AND URINARY EXCRETION OF CIPROFLOXACIN IN GOATSZ. IQBAL, I. JAVED, B. ASLAM, F. MUHAMMAD AND I. U. JANThe renal clearance and urinary excretion of ciprofloxacin were investigated in eight healthy female goats. In each animal, ciprofloxacin was administered intramuscularly at the rate of 5 mg/kg body weight. Following drug administration, blood and urine samples were collected at different time intervals and analyzed for ciprofloxacin and creatinine. High performance liquid chromatography (HPLC) was used to determine the drug concentration in the plasma and urine. The value of diuresis after single administration of ciprofloxacin was 0.073 ± 0.014 ml/min/kg. Mean (± SE) values for renal clearance of creatinine and ciprofloxacin were 1.870 ± 0.385 and 0.982 ± 0.166 ml/min/kg, respectively. The ratio between the renal clearance of ciprofloxacin and that of creatinine remained less than one, which was indicative of back diffusion. The mean (± SE) value for the cumulative percent of ciprofloxacin dose excreted at 10 hours following its intramuscular administration was 13.03 ± 2.07. Based on these results, it was evident that besides glomerular filtration, renal handling of drug involved back diffusion also. It was concluded that in local goats glomerular filtration rate (GFR) was lower than that reported for their foreign counterparts.http://pvj.com.pk/pdf-files/27_4/179-183.pdfRenal clearanceurinary excretionciprofloxacinpgoats |
| spellingShingle | Z. IQBAL, I. JAVED, B. ASLAM, F. MUHAMMAD AND I. U. JAN RENAL CLEARANCE AND URINARY EXCRETION OF CIPROFLOXACIN IN GOATS Pakistan Veterinary Journal Renal clearance urinary excretion ciprofloxacinp goats |
| title | RENAL CLEARANCE AND URINARY EXCRETION OF CIPROFLOXACIN IN GOATS |
| title_full | RENAL CLEARANCE AND URINARY EXCRETION OF CIPROFLOXACIN IN GOATS |
| title_fullStr | RENAL CLEARANCE AND URINARY EXCRETION OF CIPROFLOXACIN IN GOATS |
| title_full_unstemmed | RENAL CLEARANCE AND URINARY EXCRETION OF CIPROFLOXACIN IN GOATS |
| title_short | RENAL CLEARANCE AND URINARY EXCRETION OF CIPROFLOXACIN IN GOATS |
| title_sort | renal clearance and urinary excretion of ciprofloxacin in goats |
| topic | Renal clearance urinary excretion ciprofloxacinp goats |
| url | http://pvj.com.pk/pdf-files/27_4/179-183.pdf |
| work_keys_str_mv | AT ziqbalijavedbaslamfmuhammadandiujan renalclearanceandurinaryexcretionofciprofloxaciningoats |