Ln(III) Complexes Embedded in Biocompatible PLGA Nanoparticles as Potential Vis-to-NIR Optical Probes
In this contribution, we present the spectroscopic study of two NIR emitting hydrophobic heteroleptic (<i>R</i>,<i>R</i>)-Yb<b>L1</b>(tta) and (<i>R</i>,<i>R</i>)-Nd<b>L1</b>(tta) complexes (with tta = 2-thenoyltrifluoroacetonat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/5/2251 |
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| author | Fabio Piccinelli Silvia Mizzoni Giorgia Zanella Salvatore Calogero Gaglio Massimiliano Perduca Alessandro Romeo Silvia Ruggieri Chiara Nardon Enrico Cavalli |
| author_facet | Fabio Piccinelli Silvia Mizzoni Giorgia Zanella Salvatore Calogero Gaglio Massimiliano Perduca Alessandro Romeo Silvia Ruggieri Chiara Nardon Enrico Cavalli |
| author_sort | Fabio Piccinelli |
| collection | DOAJ |
| description | In this contribution, we present the spectroscopic study of two NIR emitting hydrophobic heteroleptic (<i>R</i>,<i>R</i>)-Yb<b>L1</b>(tta) and (<i>R</i>,<i>R</i>)-Nd<b>L1</b>(tta) complexes (with tta = 2-thenoyltrifluoroacetonate and <b>L1</b> = N,N′-bis(2-(8-hydroxyquinolinate)methylidene)-1,2-(<i>R</i>,<i>R</i> or <i>S</i>,<i>S</i>)-cyclohexanediamine), both in methanol solution and embedded in water dispersible and biocompatible poly lactic-co-glycolic acid (PLGA) nanoparticles. Thanks to their absorption properties in a wide range of wavelengths extending from the UV up to the blue and green visible regions, the emission of these complexes can be effectively sensitized using visible radiation, which is much less harmful to tissues and skin than the UV one. The encapsulation of the two Ln(III)-based complexes in PLGA allows us to preserve their nature, making them stable in water and to test their cytotoxicity on two different cell lines, with the aim of using them in the future as potential bioimaging optical probes. |
| first_indexed | 2024-03-11T07:16:12Z |
| format | Article |
| id | doaj.art-17405b5d429443e394cda1bd315c8915 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T07:16:12Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-17405b5d429443e394cda1bd315c89152023-11-17T08:14:03ZengMDPI AGMolecules1420-30492023-02-01285225110.3390/molecules28052251Ln(III) Complexes Embedded in Biocompatible PLGA Nanoparticles as Potential Vis-to-NIR Optical ProbesFabio Piccinelli0Silvia Mizzoni1Giorgia Zanella2Salvatore Calogero Gaglio3Massimiliano Perduca4Alessandro Romeo5Silvia Ruggieri6Chiara Nardon7Enrico Cavalli8Luminescent Materials Laboratory, DB, University of Verona, and INSTM, UdR Verona, Strada Le Grazie 15, 37134 Verona, ItalyLuminescent Materials Laboratory, DB, University of Verona, and INSTM, UdR Verona, Strada Le Grazie 15, 37134 Verona, ItalyBiocrystallography and Nanostructure Laboratory, Department of Biotechnology, University of Verona, Strada Le Grazie 15, 37134 Verona, ItalyBiocrystallography and Nanostructure Laboratory, Department of Biotechnology, University of Verona, Strada Le Grazie 15, 37134 Verona, ItalyBiocrystallography and Nanostructure Laboratory, Department of Biotechnology, University of Verona, Strada Le Grazie 15, 37134 Verona, ItalyDepartment of Computer Science, University of Verona, Strada Le Grazie 15, 37134 Verona, ItalyLuminescent Materials Laboratory, DB, University of Verona, and INSTM, UdR Verona, Strada Le Grazie 15, 37134 Verona, ItalyLuminescent Materials Laboratory, DB, University of Verona, and INSTM, UdR Verona, Strada Le Grazie 15, 37134 Verona, ItalyDepartment of Chemical Sciences, Life and Environmental Sustainability, University of Parma, Parco Area delle Scienze, 11/a, 43124 Parma, ItalyIn this contribution, we present the spectroscopic study of two NIR emitting hydrophobic heteroleptic (<i>R</i>,<i>R</i>)-Yb<b>L1</b>(tta) and (<i>R</i>,<i>R</i>)-Nd<b>L1</b>(tta) complexes (with tta = 2-thenoyltrifluoroacetonate and <b>L1</b> = N,N′-bis(2-(8-hydroxyquinolinate)methylidene)-1,2-(<i>R</i>,<i>R</i> or <i>S</i>,<i>S</i>)-cyclohexanediamine), both in methanol solution and embedded in water dispersible and biocompatible poly lactic-co-glycolic acid (PLGA) nanoparticles. Thanks to their absorption properties in a wide range of wavelengths extending from the UV up to the blue and green visible regions, the emission of these complexes can be effectively sensitized using visible radiation, which is much less harmful to tissues and skin than the UV one. The encapsulation of the two Ln(III)-based complexes in PLGA allows us to preserve their nature, making them stable in water and to test their cytotoxicity on two different cell lines, with the aim of using them in the future as potential bioimaging optical probes.https://www.mdpi.com/1420-3049/28/5/2251ytterbiumneodimiumNIR luminescencevisible excitationPLGAnanoparticles |
| spellingShingle | Fabio Piccinelli Silvia Mizzoni Giorgia Zanella Salvatore Calogero Gaglio Massimiliano Perduca Alessandro Romeo Silvia Ruggieri Chiara Nardon Enrico Cavalli Ln(III) Complexes Embedded in Biocompatible PLGA Nanoparticles as Potential Vis-to-NIR Optical Probes Molecules ytterbium neodimium NIR luminescence visible excitation PLGA nanoparticles |
| title | Ln(III) Complexes Embedded in Biocompatible PLGA Nanoparticles as Potential Vis-to-NIR Optical Probes |
| title_full | Ln(III) Complexes Embedded in Biocompatible PLGA Nanoparticles as Potential Vis-to-NIR Optical Probes |
| title_fullStr | Ln(III) Complexes Embedded in Biocompatible PLGA Nanoparticles as Potential Vis-to-NIR Optical Probes |
| title_full_unstemmed | Ln(III) Complexes Embedded in Biocompatible PLGA Nanoparticles as Potential Vis-to-NIR Optical Probes |
| title_short | Ln(III) Complexes Embedded in Biocompatible PLGA Nanoparticles as Potential Vis-to-NIR Optical Probes |
| title_sort | ln iii complexes embedded in biocompatible plga nanoparticles as potential vis to nir optical probes |
| topic | ytterbium neodimium NIR luminescence visible excitation PLGA nanoparticles |
| url | https://www.mdpi.com/1420-3049/28/5/2251 |
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