Seroprevalence of SARS-CoV-2 antibodies among healthcare workers in Dutch hospitals after the 2020 first wave: a multicentre cross-sectional study with prospective follow-up
Abstract Background We aimed to estimate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence and describe its determinants and associated symptoms among unvaccinated healthcare workers (HCWs) after the first wave of the pandemic. Methods HCWs from 13 Dutch hospitals were...
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| Language: | English |
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BMC
2023-11-01
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| Series: | Antimicrobial Resistance and Infection Control |
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| Online Access: | https://doi.org/10.1186/s13756-023-01324-x |
| _version_ | 1797413960321859584 |
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| author | Claudia Recanatini Corine H. GeurtsvanKessel Suzan D. Pas Els M. Broens Martje Maas Rosa van Mansfeld Anne J. G. Mutsaers-van Oudheusden Miranda van Rijen Emile F. Schippers Arjan Stegeman Adriana Tami Karin Ellen Veldkamp Hannah Visser Andreas Voss Marjolijn C. A. Wegdam-Blans Heiman F. L. Wertheim Peter C. Wever Marion P. G. Koopmans Jan A. J. W. Kluytmans Marjolein F. Q. Kluytmans-van den Bergh COCON Study Group |
| author_facet | Claudia Recanatini Corine H. GeurtsvanKessel Suzan D. Pas Els M. Broens Martje Maas Rosa van Mansfeld Anne J. G. Mutsaers-van Oudheusden Miranda van Rijen Emile F. Schippers Arjan Stegeman Adriana Tami Karin Ellen Veldkamp Hannah Visser Andreas Voss Marjolijn C. A. Wegdam-Blans Heiman F. L. Wertheim Peter C. Wever Marion P. G. Koopmans Jan A. J. W. Kluytmans Marjolein F. Q. Kluytmans-van den Bergh COCON Study Group |
| author_sort | Claudia Recanatini |
| collection | DOAJ |
| description | Abstract Background We aimed to estimate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence and describe its determinants and associated symptoms among unvaccinated healthcare workers (HCWs) after the first wave of the pandemic. Methods HCWs from 13 Dutch hospitals were screened for antibodies against the spike protein of SARS-CoV-2 in June-July 2020 and after three months. Participants completed a retrospective questionnaire on determinants for occupational and community exposure to SARS-CoV-2 and symptoms suggestive of COVID-19 experienced since January 2020. The seroprevalence was calculated per baseline characteristic and symptom at baseline and after follow-up. Adjusted odds ratios (aOR) for seropositivity were determined using logistic regression. Results Among 2328 HCWs, 323 (13.9%) were seropositive at enrolment, 49 of whom (15%) reported no previous symptoms suggestive of COVID-19. During follow-up, only 1% of the tested participants seroconverted. Seroprevalence was higher in younger HCWs compared to the mid-age category (aOR 1.53, 95% CI 1.07–2.18). Nurses (aOR 2.21, 95% CI 1.34–3.64) and administrative staff (aOR 1.87, 95% CI 1.02–3.43) had a higher seroprevalence than physicians. The highest seroprevalence was observed in HCWs in the emergency department (ED) (aOR 1.79, 95% CI 1.10–2.91), the lowest in HCWs in the intensive, high, or medium care units (aOR 0.47, 95% CI 0.31–0.71). Chronic respiratory disease, smoking, and having a dog were independently associated with a lower seroprevalence, while HCWs with diabetes mellitus had a higher seroprevalence. In a multivariable model containing all self-reported symptoms since January 2020, altered smell and taste, fever, general malaise/fatigue, and muscle aches were positively associated with developing antibodies, while sore throat and chills were negatively associated. Conclusions The SARS-CoV-2 seroprevalence in unvaccinated HCWs of 13 Dutch hospitals was 14% in June-July 2020 and remained stable after three months. A higher seroprevalence was observed in the ED and among nurses, administrative and young staff, and those with diabetes mellitus, while a lower seroprevalence was found in HCWs in intensive, high, or medium care, and those with self-reported lung disease, smokers, and dog owners. A history of altered smell or taste, fever, muscle aches and fatigue were independently associated with the presence of SARS-CoV-2 antibodies in unvaccinated HCWs. |
| first_indexed | 2024-03-09T05:25:57Z |
| format | Article |
| id | doaj.art-1740da4d3567459e929854ca5a3a6607 |
| institution | Directory Open Access Journal |
| issn | 2047-2994 |
| language | English |
| last_indexed | 2024-03-09T05:25:57Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Antimicrobial Resistance and Infection Control |
| spelling | doaj.art-1740da4d3567459e929854ca5a3a66072023-12-03T12:36:49ZengBMCAntimicrobial Resistance and Infection Control2047-29942023-11-0112111510.1186/s13756-023-01324-xSeroprevalence of SARS-CoV-2 antibodies among healthcare workers in Dutch hospitals after the 2020 first wave: a multicentre cross-sectional study with prospective follow-upClaudia Recanatini0Corine H. GeurtsvanKessel1Suzan D. Pas2Els M. Broens3Martje Maas4Rosa van Mansfeld5Anne J. G. Mutsaers-van Oudheusden6Miranda van Rijen7Emile F. Schippers8Arjan Stegeman9Adriana Tami10Karin Ellen Veldkamp11Hannah Visser12Andreas Voss13Marjolijn C. A. Wegdam-Blans14Heiman F. L. Wertheim15Peter C. Wever16Marion P. G. Koopmans17Jan A. J. W. Kluytmans18Marjolein F. Q. Kluytmans-van den Bergh19COCON Study GroupJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht UniversityViroscience Department, Erasmus University Medical CenterMicrovida Laboratory for Medical Microbiology, Bravis HospitalDepartment Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityDepartment of Internal Medicine, Bernhoven HospitalDepartment of Medical Microbiology, Amsterdam University Medical Centers, University of AmsterdamDepartment of Infection Control, Elisabeth-TweeSteden HospitalDepartment of Infection Control, Amphia HospitalDepartment of Internal Medicine, Haga HospitalDepartment of Population Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityDepartment of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center GroningenDepartment of Medical Microbiology, Leiden University Medical CenterDepartment of Internal Medicine, Beatrix HospitalDepartment of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina HospitalCatharina HospitalRadboud Center for Infectious Diseases, Radboud University Medical CenterDepartment of Medical Microbiology and Infection Control, Jeroen Bosch HospitalViroscience Department, Erasmus University Medical CenterJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht UniversityJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht UniversityAbstract Background We aimed to estimate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence and describe its determinants and associated symptoms among unvaccinated healthcare workers (HCWs) after the first wave of the pandemic. Methods HCWs from 13 Dutch hospitals were screened for antibodies against the spike protein of SARS-CoV-2 in June-July 2020 and after three months. Participants completed a retrospective questionnaire on determinants for occupational and community exposure to SARS-CoV-2 and symptoms suggestive of COVID-19 experienced since January 2020. The seroprevalence was calculated per baseline characteristic and symptom at baseline and after follow-up. Adjusted odds ratios (aOR) for seropositivity were determined using logistic regression. Results Among 2328 HCWs, 323 (13.9%) were seropositive at enrolment, 49 of whom (15%) reported no previous symptoms suggestive of COVID-19. During follow-up, only 1% of the tested participants seroconverted. Seroprevalence was higher in younger HCWs compared to the mid-age category (aOR 1.53, 95% CI 1.07–2.18). Nurses (aOR 2.21, 95% CI 1.34–3.64) and administrative staff (aOR 1.87, 95% CI 1.02–3.43) had a higher seroprevalence than physicians. The highest seroprevalence was observed in HCWs in the emergency department (ED) (aOR 1.79, 95% CI 1.10–2.91), the lowest in HCWs in the intensive, high, or medium care units (aOR 0.47, 95% CI 0.31–0.71). Chronic respiratory disease, smoking, and having a dog were independently associated with a lower seroprevalence, while HCWs with diabetes mellitus had a higher seroprevalence. In a multivariable model containing all self-reported symptoms since January 2020, altered smell and taste, fever, general malaise/fatigue, and muscle aches were positively associated with developing antibodies, while sore throat and chills were negatively associated. Conclusions The SARS-CoV-2 seroprevalence in unvaccinated HCWs of 13 Dutch hospitals was 14% in June-July 2020 and remained stable after three months. A higher seroprevalence was observed in the ED and among nurses, administrative and young staff, and those with diabetes mellitus, while a lower seroprevalence was found in HCWs in intensive, high, or medium care, and those with self-reported lung disease, smokers, and dog owners. A history of altered smell or taste, fever, muscle aches and fatigue were independently associated with the presence of SARS-CoV-2 antibodies in unvaccinated HCWs.https://doi.org/10.1186/s13756-023-01324-xSeroprevalenceSARS-CoV-2COVID-19AntibodiesRisk factorSelf-reported symptoms |
| spellingShingle | Claudia Recanatini Corine H. GeurtsvanKessel Suzan D. Pas Els M. Broens Martje Maas Rosa van Mansfeld Anne J. G. Mutsaers-van Oudheusden Miranda van Rijen Emile F. Schippers Arjan Stegeman Adriana Tami Karin Ellen Veldkamp Hannah Visser Andreas Voss Marjolijn C. A. Wegdam-Blans Heiman F. L. Wertheim Peter C. Wever Marion P. G. Koopmans Jan A. J. W. Kluytmans Marjolein F. Q. Kluytmans-van den Bergh COCON Study Group Seroprevalence of SARS-CoV-2 antibodies among healthcare workers in Dutch hospitals after the 2020 first wave: a multicentre cross-sectional study with prospective follow-up Antimicrobial Resistance and Infection Control Seroprevalence SARS-CoV-2 COVID-19 Antibodies Risk factor Self-reported symptoms |
| title | Seroprevalence of SARS-CoV-2 antibodies among healthcare workers in Dutch hospitals after the 2020 first wave: a multicentre cross-sectional study with prospective follow-up |
| title_full | Seroprevalence of SARS-CoV-2 antibodies among healthcare workers in Dutch hospitals after the 2020 first wave: a multicentre cross-sectional study with prospective follow-up |
| title_fullStr | Seroprevalence of SARS-CoV-2 antibodies among healthcare workers in Dutch hospitals after the 2020 first wave: a multicentre cross-sectional study with prospective follow-up |
| title_full_unstemmed | Seroprevalence of SARS-CoV-2 antibodies among healthcare workers in Dutch hospitals after the 2020 first wave: a multicentre cross-sectional study with prospective follow-up |
| title_short | Seroprevalence of SARS-CoV-2 antibodies among healthcare workers in Dutch hospitals after the 2020 first wave: a multicentre cross-sectional study with prospective follow-up |
| title_sort | seroprevalence of sars cov 2 antibodies among healthcare workers in dutch hospitals after the 2020 first wave a multicentre cross sectional study with prospective follow up |
| topic | Seroprevalence SARS-CoV-2 COVID-19 Antibodies Risk factor Self-reported symptoms |
| url | https://doi.org/10.1186/s13756-023-01324-x |
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