Adult-born neurons modify excitatory synaptic transmission to existing neurons
Adult-born neurons are continually produced in the dentate gyrus but it is unclear whether synaptic integration of new neurons affects the pre-existing circuit. Here we investigated how manipulating neurogenesis in adult mice alters excitatory synaptic transmission to mature dentate neurons. Enhanci...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2017-01-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/19886 |
| _version_ | 1811252614601375744 |
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| author | Elena W Adlaf Ryan J Vaden Anastasia J Niver Allison F Manuel Vincent C Onyilo Matheus T Araujo Cristina V Dieni Hai T Vo Gwendalyn D King Jacques I Wadiche Linda Overstreet-Wadiche |
| author_facet | Elena W Adlaf Ryan J Vaden Anastasia J Niver Allison F Manuel Vincent C Onyilo Matheus T Araujo Cristina V Dieni Hai T Vo Gwendalyn D King Jacques I Wadiche Linda Overstreet-Wadiche |
| author_sort | Elena W Adlaf |
| collection | DOAJ |
| description | Adult-born neurons are continually produced in the dentate gyrus but it is unclear whether synaptic integration of new neurons affects the pre-existing circuit. Here we investigated how manipulating neurogenesis in adult mice alters excitatory synaptic transmission to mature dentate neurons. Enhancing neurogenesis by conditional deletion of the pro-apoptotic gene Bax in stem cells reduced excitatory postsynaptic currents (EPSCs) and spine density in mature neurons, whereas genetic ablation of neurogenesis increased EPSCs in mature neurons. Unexpectedly, we found that Bax deletion in developing and mature dentate neurons increased EPSCs and prevented neurogenesis-induced synaptic suppression. Together these results show that neurogenesis modifies synaptic transmission to mature neurons in a manner consistent with a redistribution of pre-existing synapses to newly integrating neurons and that a non-apoptotic function of the Bax signaling pathway contributes to ongoing synaptic refinement within the dentate circuit. |
| first_indexed | 2024-04-12T16:37:18Z |
| format | Article |
| id | doaj.art-1742315f915a44d686adaa1ef0fa6d67 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T16:37:18Z |
| publishDate | 2017-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-1742315f915a44d686adaa1ef0fa6d672022-12-22T03:24:56ZengeLife Sciences Publications LtdeLife2050-084X2017-01-01610.7554/eLife.19886Adult-born neurons modify excitatory synaptic transmission to existing neuronsElena W Adlaf0Ryan J Vaden1Anastasia J Niver2Allison F Manuel3Vincent C Onyilo4Matheus T Araujo5Cristina V Dieni6Hai T Vo7Gwendalyn D King8https://orcid.org/0000-0002-3659-9241Jacques I Wadiche9https://orcid.org/0000-0001-8180-2061Linda Overstreet-Wadiche10https://orcid.org/0000-0001-7367-5998Department of Neurobiology, University of Alabama at Birmingham, Birmingham, United StatesDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, United StatesDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, United StatesDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, United StatesDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, United StatesDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, United StatesDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, United StatesDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, United StatesDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, United StatesDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, United StatesDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, United StatesAdult-born neurons are continually produced in the dentate gyrus but it is unclear whether synaptic integration of new neurons affects the pre-existing circuit. Here we investigated how manipulating neurogenesis in adult mice alters excitatory synaptic transmission to mature dentate neurons. Enhancing neurogenesis by conditional deletion of the pro-apoptotic gene Bax in stem cells reduced excitatory postsynaptic currents (EPSCs) and spine density in mature neurons, whereas genetic ablation of neurogenesis increased EPSCs in mature neurons. Unexpectedly, we found that Bax deletion in developing and mature dentate neurons increased EPSCs and prevented neurogenesis-induced synaptic suppression. Together these results show that neurogenesis modifies synaptic transmission to mature neurons in a manner consistent with a redistribution of pre-existing synapses to newly integrating neurons and that a non-apoptotic function of the Bax signaling pathway contributes to ongoing synaptic refinement within the dentate circuit.https://elifesciences.org/articles/19886adult neurogenesisdentate gyrussynaptic transmissionEPSCcompetitiongranule cells |
| spellingShingle | Elena W Adlaf Ryan J Vaden Anastasia J Niver Allison F Manuel Vincent C Onyilo Matheus T Araujo Cristina V Dieni Hai T Vo Gwendalyn D King Jacques I Wadiche Linda Overstreet-Wadiche Adult-born neurons modify excitatory synaptic transmission to existing neurons eLife adult neurogenesis dentate gyrus synaptic transmission EPSC competition granule cells |
| title | Adult-born neurons modify excitatory synaptic transmission to existing neurons |
| title_full | Adult-born neurons modify excitatory synaptic transmission to existing neurons |
| title_fullStr | Adult-born neurons modify excitatory synaptic transmission to existing neurons |
| title_full_unstemmed | Adult-born neurons modify excitatory synaptic transmission to existing neurons |
| title_short | Adult-born neurons modify excitatory synaptic transmission to existing neurons |
| title_sort | adult born neurons modify excitatory synaptic transmission to existing neurons |
| topic | adult neurogenesis dentate gyrus synaptic transmission EPSC competition granule cells |
| url | https://elifesciences.org/articles/19886 |
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