Risk Assessment of Isoeugenol in Food Based on Benchmark Dose—Response Modeling
Isoeugenol has recently been evaluated as possibly carcinogenic (Group 2B) by the WHO International Agency for Research on Cancer (IARC). In light of this evaluation, an updated risk assessment of this common food constituent was conducted using the benchmark dose (BMD) approach as recommended by th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/11/12/991 |
| _version_ | 1797379206981615616 |
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| author | Thomas Quentin Heike Franke Dirk W. Lachenmeier |
| author_facet | Thomas Quentin Heike Franke Dirk W. Lachenmeier |
| author_sort | Thomas Quentin |
| collection | DOAJ |
| description | Isoeugenol has recently been evaluated as possibly carcinogenic (Group 2B) by the WHO International Agency for Research on Cancer (IARC). In light of this evaluation, an updated risk assessment of this common food constituent was conducted using the benchmark dose (BMD) approach as recommended by the European Food Safety Authority (EFSA) for point of departure (POD) determination, as an alternative to the no observed adverse effect level (NOAEL). This approach was specifically chosen, as for the relevant neoplastic endpoints only lowest observed adverse effect level (LOAEL) values are available. The toxicological endpoint from the animal studies with the most conservative BMD lower confidence limit (BMDL) value was identified. Using the obtained BMDL value of 8 mg/kg body weight/day as POD, an acceptable daily intake (ADI) of 16 µg/kg body weight/day was obtained, which—despite being more conservative than previous approaches—is still clearly above the estimated daily exposure level to isoeugenol in the USA and in Europe. These results confirm a low risk of the estimated daily exposure levels of isoeugenol. |
| first_indexed | 2024-03-08T20:18:49Z |
| format | Article |
| id | doaj.art-1742368a343942ecadb3e40a4fd64e4d |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-08T20:18:49Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-1742368a343942ecadb3e40a4fd64e4d2023-12-22T14:46:04ZengMDPI AGToxics2305-63042023-12-01111299110.3390/toxics11120991Risk Assessment of Isoeugenol in Food Based on Benchmark Dose—Response ModelingThomas Quentin0Heike Franke1Dirk W. Lachenmeier2Postgraduate Study of Toxicology and Environmental Protection, Rudolf-Boehm-Institut für Pharmakologie und Toxikologie, Universität Leipzig, Härtelstrasse 16–18, 04107 Leipzig, GermanyPostgraduate Study of Toxicology and Environmental Protection, Rudolf-Boehm-Institut für Pharmakologie und Toxikologie, Universität Leipzig, Härtelstrasse 16–18, 04107 Leipzig, GermanyChemisches und Veterinäruntersuchungsamt (CVUA) Karlsruhe, Weissenburger Strasse 3, 76187 Karlsruhe, GermanyIsoeugenol has recently been evaluated as possibly carcinogenic (Group 2B) by the WHO International Agency for Research on Cancer (IARC). In light of this evaluation, an updated risk assessment of this common food constituent was conducted using the benchmark dose (BMD) approach as recommended by the European Food Safety Authority (EFSA) for point of departure (POD) determination, as an alternative to the no observed adverse effect level (NOAEL). This approach was specifically chosen, as for the relevant neoplastic endpoints only lowest observed adverse effect level (LOAEL) values are available. The toxicological endpoint from the animal studies with the most conservative BMD lower confidence limit (BMDL) value was identified. Using the obtained BMDL value of 8 mg/kg body weight/day as POD, an acceptable daily intake (ADI) of 16 µg/kg body weight/day was obtained, which—despite being more conservative than previous approaches—is still clearly above the estimated daily exposure level to isoeugenol in the USA and in Europe. These results confirm a low risk of the estimated daily exposure levels of isoeugenol.https://www.mdpi.com/2305-6304/11/12/991benchmark doseisoeugenolacceptable daily intakecancer risk |
| spellingShingle | Thomas Quentin Heike Franke Dirk W. Lachenmeier Risk Assessment of Isoeugenol in Food Based on Benchmark Dose—Response Modeling Toxics benchmark dose isoeugenol acceptable daily intake cancer risk |
| title | Risk Assessment of Isoeugenol in Food Based on Benchmark Dose—Response Modeling |
| title_full | Risk Assessment of Isoeugenol in Food Based on Benchmark Dose—Response Modeling |
| title_fullStr | Risk Assessment of Isoeugenol in Food Based on Benchmark Dose—Response Modeling |
| title_full_unstemmed | Risk Assessment of Isoeugenol in Food Based on Benchmark Dose—Response Modeling |
| title_short | Risk Assessment of Isoeugenol in Food Based on Benchmark Dose—Response Modeling |
| title_sort | risk assessment of isoeugenol in food based on benchmark dose response modeling |
| topic | benchmark dose isoeugenol acceptable daily intake cancer risk |
| url | https://www.mdpi.com/2305-6304/11/12/991 |
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