Chinese herbal medicine for hand-foot-and-mouth disease in children: An overview of systematic reviews
Objective: To summarize the use of Chinese herbal medicines (CHM) for the treatment of hand-foot-and-mouth disease (HFMD) in children and to provide high-level evidence for clinical decision-making. Methods: We conducted an overview of systematic reviews (SRs). Two English-language and four Chinese-...
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Format: | Article |
Language: | English |
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Elsevier
2018-04-01
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Series: | Journal of Traditional Chinese Medical Sciences |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2095754818300425 |
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author | Ruohan Wu Shigang Liu Jin Sun Lily Lai Jianping Liu |
author_facet | Ruohan Wu Shigang Liu Jin Sun Lily Lai Jianping Liu |
author_sort | Ruohan Wu |
collection | DOAJ |
description | Objective: To summarize the use of Chinese herbal medicines (CHM) for the treatment of hand-foot-and-mouth disease (HFMD) in children and to provide high-level evidence for clinical decision-making. Methods: We conducted an overview of systematic reviews (SRs). Two English-language and four Chinese-language electronic databases were searched from inception to March 31, 2018. Published SRs and meta-analyses evaluating CHM use in children with HFMD and reporting clinically-relevant outcomes such as time to fever resolution were eligible for inclusion in this overview. Reviews were accepted if the intervention featured CHM with or without other treatment. Two authors evaluated the methodological quality of the included SRs by using ASMTAR and ROBIS. Results: Thirty SRs comprising 90 244 children with HFMD were included in this overview of SRs. All SRs were published in Chinese between 2011 and 2017. All intervention arms received CHM with or without conventional treatment and were compared against control arms receiving no treatment, conventional treatment alone, or placebo. All 30 reviews reported the time to fever resolution and results demonstrated that CHM had a greater benefit in reducing fever compared with controls. Twenty-three reviews reported the time to rash resolution which presented similar results. Fourteen SRs reported the time to oral ulcer healing and CHM demonstrated a significantly reduced time to resolution compared to controls. The quality of the included SRs was low to moderate as assessed by the AMSTAR tool. Conclusion: Published reviews demonstrated potential benefits of CHM in children with HFMD. Overall, the methodological quality of reviews included in this overview of SRs was low and our findings should be interpreted with caution. We would strongly recommend that future SRs be designed and reported rigorously following PRISMA in order to provide more robust evidence on which to base clinical guidance. Keywords: Chinese herbal medicine, Hand-foot-mouth disease, Overview, AMSTAR, ROBIS |
first_indexed | 2024-03-12T10:22:20Z |
format | Article |
id | doaj.art-17423e3dd7a6414b867bf9d9ef378fc6 |
institution | Directory Open Access Journal |
issn | 2095-7548 |
language | English |
last_indexed | 2024-03-12T10:22:20Z |
publishDate | 2018-04-01 |
publisher | Elsevier |
record_format | Article |
series | Journal of Traditional Chinese Medical Sciences |
spelling | doaj.art-17423e3dd7a6414b867bf9d9ef378fc62023-09-02T09:58:19ZengElsevierJournal of Traditional Chinese Medical Sciences2095-75482018-04-01528393Chinese herbal medicine for hand-foot-and-mouth disease in children: An overview of systematic reviewsRuohan Wu0Shigang Liu1Jin Sun2Lily Lai3Jianping Liu4Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, ChinaDepartment of Respiratory Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, ChinaComplementary and Integrated Medicine Research Unit, Primary Care and Population Sciences, University of Southampton, SO16 5ST, UKCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China; Corresponding author.Objective: To summarize the use of Chinese herbal medicines (CHM) for the treatment of hand-foot-and-mouth disease (HFMD) in children and to provide high-level evidence for clinical decision-making. Methods: We conducted an overview of systematic reviews (SRs). Two English-language and four Chinese-language electronic databases were searched from inception to March 31, 2018. Published SRs and meta-analyses evaluating CHM use in children with HFMD and reporting clinically-relevant outcomes such as time to fever resolution were eligible for inclusion in this overview. Reviews were accepted if the intervention featured CHM with or without other treatment. Two authors evaluated the methodological quality of the included SRs by using ASMTAR and ROBIS. Results: Thirty SRs comprising 90 244 children with HFMD were included in this overview of SRs. All SRs were published in Chinese between 2011 and 2017. All intervention arms received CHM with or without conventional treatment and were compared against control arms receiving no treatment, conventional treatment alone, or placebo. All 30 reviews reported the time to fever resolution and results demonstrated that CHM had a greater benefit in reducing fever compared with controls. Twenty-three reviews reported the time to rash resolution which presented similar results. Fourteen SRs reported the time to oral ulcer healing and CHM demonstrated a significantly reduced time to resolution compared to controls. The quality of the included SRs was low to moderate as assessed by the AMSTAR tool. Conclusion: Published reviews demonstrated potential benefits of CHM in children with HFMD. Overall, the methodological quality of reviews included in this overview of SRs was low and our findings should be interpreted with caution. We would strongly recommend that future SRs be designed and reported rigorously following PRISMA in order to provide more robust evidence on which to base clinical guidance. Keywords: Chinese herbal medicine, Hand-foot-mouth disease, Overview, AMSTAR, ROBIShttp://www.sciencedirect.com/science/article/pii/S2095754818300425 |
spellingShingle | Ruohan Wu Shigang Liu Jin Sun Lily Lai Jianping Liu Chinese herbal medicine for hand-foot-and-mouth disease in children: An overview of systematic reviews Journal of Traditional Chinese Medical Sciences |
title | Chinese herbal medicine for hand-foot-and-mouth disease in children: An overview of systematic reviews |
title_full | Chinese herbal medicine for hand-foot-and-mouth disease in children: An overview of systematic reviews |
title_fullStr | Chinese herbal medicine for hand-foot-and-mouth disease in children: An overview of systematic reviews |
title_full_unstemmed | Chinese herbal medicine for hand-foot-and-mouth disease in children: An overview of systematic reviews |
title_short | Chinese herbal medicine for hand-foot-and-mouth disease in children: An overview of systematic reviews |
title_sort | chinese herbal medicine for hand foot and mouth disease in children an overview of systematic reviews |
url | http://www.sciencedirect.com/science/article/pii/S2095754818300425 |
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