HIV-1 Tat Dysregulates the Hypothalamic-Pituitary-Adrenal Stress Axis and Potentiates Oxycodone-Mediated Psychomotor and Anxiety-Like Behavior of Male Mice

HIV-1 Tat Dysregulates the Hypothalamic-Pituitary-Adrenal Stress Axis and Potentiates Oxycodone-Mediated Psychomotor and Anxiety-Like Behavior of Male Mice

Human immunodeficiency virus (HIV) is associated with co-morbid affective and stress-sensitive neuropsychiatric disorders that may be related to dysfunction of the hypothalamic-pituitary-adrenal (HPA) stress axis. The HPA axis is perturbed in up to 46% of HIV patients, but the mechanisms are not kno...

Full description

Bibliographic Details
Main Authors: Mohammed F. Salahuddin, Fakhri Mahdi, Jason J. Paris
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
adrenal insufficiency
antalarmin
hypothalamic-pituitary-adrenal axis
opioids
trans-activator of transcription
RU-486
Online Access:https://www.mdpi.com/1422-0067/21/21/8212

Internet

https://www.mdpi.com/1422-0067/21/21/8212

Similar Items