Correlation of variable repeat number in the neck regions of DC-SIGN and DC-SIGNR with susceptibility to nasopharyngeal carcinoma in a Chinese population
Sisi Ning,1,* Mengwei Yao,1,* Yuan Wu,1 Xunzhao Zhou,1 Changtao Zhong,1 Kui Yan,1 Zhengbo Wei,2 Ying Xie3,4 1Graduate School of Guangxi Medical University, Nanning, China; 2Department of Head and Neck Tumor Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China; 3Life Scien...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-09-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/correlation-of-variable-repeat-number-in-the-neck-regions-of-dc-sign-a-peer-reviewed-article-CMAR |
| _version_ | 1818341167617540096 |
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| author | Ning S Yao M Wu Y Zhou X Zhong C Yan K Wei Z Xie Y |
| author_facet | Ning S Yao M Wu Y Zhou X Zhong C Yan K Wei Z Xie Y |
| author_sort | Ning S |
| collection | DOAJ |
| description | Sisi Ning,1,* Mengwei Yao,1,* Yuan Wu,1 Xunzhao Zhou,1 Changtao Zhong,1 Kui Yan,1 Zhengbo Wei,2 Ying Xie3,4 1Graduate School of Guangxi Medical University, Nanning, China; 2Department of Head and Neck Tumor Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China; 3Life Sciences Institute of Guangxi Medical University, Nanning, China; 4Key Laboratory for High-Incidence Tumor Prevention and Treatment, Guangxi Medical University, Ministry of Education, Nanning, China *These authors contributed equally to this work Objective: To evaluate the potential association of variations in the number of tandem repeats in the dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) and dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin-related (DC-SIGNR) neck region with susceptibility to nasopharyngeal carcinoma (NPC).Methods: Variations in the number of repeats in the genotypes and alleles in the neck region of DC-SIGN/DC-SIGNR were analyzed in 477 unrelated NPC patients and 561 cancer-free controls.Results: Genotypes and alleles in the DC-SIGN neck region did not differ significantly between NPC patients and controls, but the 9-repeat genotype in the DC-SIGNR neck region was significantly more frequent among patients (OR 1.339, 95% CI 1.018–1.760, P=0.037). The association between this genotype and NPC remained significant after adjusting for sex, age, smoking history, and presence of immunoglobulin against Epstein–Barr virus viral capsid antigen (OR 1.625, 95% CI 1.134–2.329, P=0.0082).Conclusion: These results suggest that genotypes/alleles in the DC-SIGN neck region are not associated with NPC susceptibility, whereas the 9-repeat variant in the neck region of DC-SIGNR may increase the risk of NPC. Keywords: nasopharyngeal carcinoma, DC-SIGN, DC-SIGNR, genetic polymorphism, neck region repeat variation |
| first_indexed | 2024-12-13T15:54:30Z |
| format | Article |
| id | doaj.art-1747d102130a42b8b90ba505beb2822e |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-13T15:54:30Z |
| publishDate | 2018-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-1747d102130a42b8b90ba505beb2822e2022-12-21T23:39:22ZengDove Medical PressCancer Management and Research1179-13222018-09-01Volume 103193319840304Correlation of variable repeat number in the neck regions of DC-SIGN and DC-SIGNR with susceptibility to nasopharyngeal carcinoma in a Chinese populationNing SYao MWu YZhou XZhong CYan KWei ZXie YSisi Ning,1,* Mengwei Yao,1,* Yuan Wu,1 Xunzhao Zhou,1 Changtao Zhong,1 Kui Yan,1 Zhengbo Wei,2 Ying Xie3,4 1Graduate School of Guangxi Medical University, Nanning, China; 2Department of Head and Neck Tumor Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China; 3Life Sciences Institute of Guangxi Medical University, Nanning, China; 4Key Laboratory for High-Incidence Tumor Prevention and Treatment, Guangxi Medical University, Ministry of Education, Nanning, China *These authors contributed equally to this work Objective: To evaluate the potential association of variations in the number of tandem repeats in the dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) and dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin-related (DC-SIGNR) neck region with susceptibility to nasopharyngeal carcinoma (NPC).Methods: Variations in the number of repeats in the genotypes and alleles in the neck region of DC-SIGN/DC-SIGNR were analyzed in 477 unrelated NPC patients and 561 cancer-free controls.Results: Genotypes and alleles in the DC-SIGN neck region did not differ significantly between NPC patients and controls, but the 9-repeat genotype in the DC-SIGNR neck region was significantly more frequent among patients (OR 1.339, 95% CI 1.018–1.760, P=0.037). The association between this genotype and NPC remained significant after adjusting for sex, age, smoking history, and presence of immunoglobulin against Epstein–Barr virus viral capsid antigen (OR 1.625, 95% CI 1.134–2.329, P=0.0082).Conclusion: These results suggest that genotypes/alleles in the DC-SIGN neck region are not associated with NPC susceptibility, whereas the 9-repeat variant in the neck region of DC-SIGNR may increase the risk of NPC. Keywords: nasopharyngeal carcinoma, DC-SIGN, DC-SIGNR, genetic polymorphism, neck region repeat variationhttps://www.dovepress.com/correlation-of-variable-repeat-number-in-the-neck-regions-of-dc-sign-a-peer-reviewed-article-CMARnasopharyngeal carcinomaDC-SIGNDC-SIGNRgenetic polymorphismneck region repeat variation |
| spellingShingle | Ning S Yao M Wu Y Zhou X Zhong C Yan K Wei Z Xie Y Correlation of variable repeat number in the neck regions of DC-SIGN and DC-SIGNR with susceptibility to nasopharyngeal carcinoma in a Chinese population Cancer Management and Research nasopharyngeal carcinoma DC-SIGN DC-SIGNR genetic polymorphism neck region repeat variation |
| title | Correlation of variable repeat number in the neck regions of DC-SIGN and DC-SIGNR with susceptibility to nasopharyngeal carcinoma in a Chinese population |
| title_full | Correlation of variable repeat number in the neck regions of DC-SIGN and DC-SIGNR with susceptibility to nasopharyngeal carcinoma in a Chinese population |
| title_fullStr | Correlation of variable repeat number in the neck regions of DC-SIGN and DC-SIGNR with susceptibility to nasopharyngeal carcinoma in a Chinese population |
| title_full_unstemmed | Correlation of variable repeat number in the neck regions of DC-SIGN and DC-SIGNR with susceptibility to nasopharyngeal carcinoma in a Chinese population |
| title_short | Correlation of variable repeat number in the neck regions of DC-SIGN and DC-SIGNR with susceptibility to nasopharyngeal carcinoma in a Chinese population |
| title_sort | correlation of variable repeat number in the neck regions of dc sign and dc signr with susceptibility to nasopharyngeal carcinoma in a chinese population |
| topic | nasopharyngeal carcinoma DC-SIGN DC-SIGNR genetic polymorphism neck region repeat variation |
| url | https://www.dovepress.com/correlation-of-variable-repeat-number-in-the-neck-regions-of-dc-sign-a-peer-reviewed-article-CMAR |
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