Acetylcholine synergizes with netrin-1 to drive persistent firing in the entorhinal cortex
Summary: The ability of the mammalian brain to maintain spatial representations of external or internal information for short periods of time has been associated with sustained neuronal spiking and reverberatory neural network activity in the medial entorhinal cortex. Here, we show that conditional...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724001402 |
| _version_ | 1797291749463293952 |
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| author | Stephen D. Glasgow Teddy A.J. Fisher Edwin W. Wong Kevin Lançon Kira M. Feighan Ian V. Beamish Julien Gibon Philippe Séguéla Edward S. Ruthazer Timothy E. Kennedy |
| author_facet | Stephen D. Glasgow Teddy A.J. Fisher Edwin W. Wong Kevin Lançon Kira M. Feighan Ian V. Beamish Julien Gibon Philippe Séguéla Edward S. Ruthazer Timothy E. Kennedy |
| author_sort | Stephen D. Glasgow |
| collection | DOAJ |
| description | Summary: The ability of the mammalian brain to maintain spatial representations of external or internal information for short periods of time has been associated with sustained neuronal spiking and reverberatory neural network activity in the medial entorhinal cortex. Here, we show that conditional genetic deletion of netrin-1 or the netrin receptor deleted-in-colorectal cancer (DCC) from forebrain excitatory neurons leads to deficits in short-term spatial memory. We then demonstrate that conditional deletion of either netrin-1 or DCC inhibits cholinergic persistent firing and show that cholinergic activation of muscarinic receptors expressed by entorhinal cortical neurons promotes persistent firing by recruiting DCC to the plasma membrane. Together, these findings indicate that normal short-term spatial memory function requires the synergistic actions of acetylcholine and netrin-1. |
| first_indexed | 2024-03-07T19:42:13Z |
| format | Article |
| id | doaj.art-174874b08ee846af9d11921e5d716470 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-07T19:42:13Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-174874b08ee846af9d11921e5d7164702024-02-29T05:19:02ZengElsevierCell Reports2211-12472024-02-01432113812Acetylcholine synergizes with netrin-1 to drive persistent firing in the entorhinal cortexStephen D. Glasgow0Teddy A.J. Fisher1Edwin W. Wong2Kevin Lançon3Kira M. Feighan4Ian V. Beamish5Julien Gibon6Philippe Séguéla7Edward S. Ruthazer8Timothy E. Kennedy9Department of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montréal, QC H3A 2B4, CanadaDepartment of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montréal, QC H3A 2B4, CanadaDepartment of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montréal, QC H3A 2B4, CanadaDepartment of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montréal, QC H3A 2B4, CanadaDepartment of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montréal, QC H3A 2B4, CanadaDepartment of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montréal, QC H3A 2B4, CanadaDepartment of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montréal, QC H3A 2B4, CanadaDepartment of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montréal, QC H3A 2B4, CanadaDepartment of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montréal, QC H3A 2B4, Canada; Corresponding authorDepartment of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montréal, QC H3A 2B4, Canada; Corresponding authorSummary: The ability of the mammalian brain to maintain spatial representations of external or internal information for short periods of time has been associated with sustained neuronal spiking and reverberatory neural network activity in the medial entorhinal cortex. Here, we show that conditional genetic deletion of netrin-1 or the netrin receptor deleted-in-colorectal cancer (DCC) from forebrain excitatory neurons leads to deficits in short-term spatial memory. We then demonstrate that conditional deletion of either netrin-1 or DCC inhibits cholinergic persistent firing and show that cholinergic activation of muscarinic receptors expressed by entorhinal cortical neurons promotes persistent firing by recruiting DCC to the plasma membrane. Together, these findings indicate that normal short-term spatial memory function requires the synergistic actions of acetylcholine and netrin-1.http://www.sciencedirect.com/science/article/pii/S2211124724001402CP: Neuroscience |
| spellingShingle | Stephen D. Glasgow Teddy A.J. Fisher Edwin W. Wong Kevin Lançon Kira M. Feighan Ian V. Beamish Julien Gibon Philippe Séguéla Edward S. Ruthazer Timothy E. Kennedy Acetylcholine synergizes with netrin-1 to drive persistent firing in the entorhinal cortex Cell Reports CP: Neuroscience |
| title | Acetylcholine synergizes with netrin-1 to drive persistent firing in the entorhinal cortex |
| title_full | Acetylcholine synergizes with netrin-1 to drive persistent firing in the entorhinal cortex |
| title_fullStr | Acetylcholine synergizes with netrin-1 to drive persistent firing in the entorhinal cortex |
| title_full_unstemmed | Acetylcholine synergizes with netrin-1 to drive persistent firing in the entorhinal cortex |
| title_short | Acetylcholine synergizes with netrin-1 to drive persistent firing in the entorhinal cortex |
| title_sort | acetylcholine synergizes with netrin 1 to drive persistent firing in the entorhinal cortex |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724001402 |
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