Toward a broader understanding of aldosterone in congestive heart failure
Discovered some 50 years ago, aldosterone (ALDO) has come to be recognised as a mineralocorticoid hormone with well-known endocrine properties in epithelial cells that contribute to the pathophysiology of congestive heart failure. This includes Na + resorption at the expense of K + excretion in clas...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2003-09-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.3317/jraas.2003.024 |
| _version_ | 1797288682901733376 |
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| author | Karl T Weber Yao Sun Linus A Wodi Ahmad Munir Eiman Jahangir Robert A Ahokas Ivan C Gerling Arnold E Postlethwaite Kenneth J Warrington |
| author_facet | Karl T Weber Yao Sun Linus A Wodi Ahmad Munir Eiman Jahangir Robert A Ahokas Ivan C Gerling Arnold E Postlethwaite Kenneth J Warrington |
| author_sort | Karl T Weber |
| collection | DOAJ |
| description | Discovered some 50 years ago, aldosterone (ALDO) has come to be recognised as a mineralocorticoid hormone with well-known endocrine properties in epithelial cells that contribute to the pathophysiology of congestive heart failure. This includes Na + resorption at the expense of K + excretion in classic target tissues: kidneys, colon, sweat and salivary glands. Though less well known, Mg 2+ excretion is likewise enhanced by ALDO, while adrenal ALDO secretion is regulated by extracellular Mg 2+ ([Mg 2+ ] o ). An emerging body of information has and continues to identify other endocrine actions of ALDO receptor-ligand binding. They include: promoting an efflux of cytosolic free Mg 2+ , or [Mg 2+ ] i , in exchange for Na + in such non-epithelial cells as peripheral blood mononuclear cells; its influence on endothelial cell function; and its central actions that involve regulation of cerebrospinal fluid composition produced by epithelial cells of the choroid plexus, activity of the hypothalamic paraventricular nucleus involved in Na + appetite, Na + and H 2 O excretion and sympathetic nerve activity, and the regulation of TNF-α production from central and/or peripheral sources. Extra-adrenal steroidogenesi and auto/paracrine properties of ALDO generated de novo in the cardiovasculature are now under investigation and preliminary findings suggest they contribute to tissue repair. The past decade has witnessed a revival of interest in this steroid molecule. In years to come, an even broader understanding of ALDO's contribution to the pathophysiology of congestive heart failure will undoubtedly emerge. |
| first_indexed | 2024-03-07T18:53:02Z |
| format | Article |
| id | doaj.art-174989cc06a54ee5bdaf87d6667e4dbb |
| institution | Directory Open Access Journal |
| issn | 1470-3203 |
| language | English |
| last_indexed | 2024-03-07T18:53:02Z |
| publishDate | 2003-09-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-174989cc06a54ee5bdaf87d6667e4dbb2024-03-02T00:52:34ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32032003-09-01410.3317/jraas.2003.024Toward a broader understanding of aldosterone in congestive heart failureKarl T Weber Yao SunLinus A WodiAhmad MunirEiman JahangirRobert A AhokasIvan C GerlingArnold E PostlethwaiteKenneth J WarringtonDiscovered some 50 years ago, aldosterone (ALDO) has come to be recognised as a mineralocorticoid hormone with well-known endocrine properties in epithelial cells that contribute to the pathophysiology of congestive heart failure. This includes Na + resorption at the expense of K + excretion in classic target tissues: kidneys, colon, sweat and salivary glands. Though less well known, Mg 2+ excretion is likewise enhanced by ALDO, while adrenal ALDO secretion is regulated by extracellular Mg 2+ ([Mg 2+ ] o ). An emerging body of information has and continues to identify other endocrine actions of ALDO receptor-ligand binding. They include: promoting an efflux of cytosolic free Mg 2+ , or [Mg 2+ ] i , in exchange for Na + in such non-epithelial cells as peripheral blood mononuclear cells; its influence on endothelial cell function; and its central actions that involve regulation of cerebrospinal fluid composition produced by epithelial cells of the choroid plexus, activity of the hypothalamic paraventricular nucleus involved in Na + appetite, Na + and H 2 O excretion and sympathetic nerve activity, and the regulation of TNF-α production from central and/or peripheral sources. Extra-adrenal steroidogenesi and auto/paracrine properties of ALDO generated de novo in the cardiovasculature are now under investigation and preliminary findings suggest they contribute to tissue repair. The past decade has witnessed a revival of interest in this steroid molecule. In years to come, an even broader understanding of ALDO's contribution to the pathophysiology of congestive heart failure will undoubtedly emerge.https://doi.org/10.3317/jraas.2003.024 |
| spellingShingle | Karl T Weber Yao Sun Linus A Wodi Ahmad Munir Eiman Jahangir Robert A Ahokas Ivan C Gerling Arnold E Postlethwaite Kenneth J Warrington Toward a broader understanding of aldosterone in congestive heart failure Journal of the Renin-Angiotensin-Aldosterone System |
| title | Toward a broader understanding of aldosterone in congestive heart failure |
| title_full | Toward a broader understanding of aldosterone in congestive heart failure |
| title_fullStr | Toward a broader understanding of aldosterone in congestive heart failure |
| title_full_unstemmed | Toward a broader understanding of aldosterone in congestive heart failure |
| title_short | Toward a broader understanding of aldosterone in congestive heart failure |
| title_sort | toward a broader understanding of aldosterone in congestive heart failure |
| url | https://doi.org/10.3317/jraas.2003.024 |
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