Caregiver burden in schizophrenia following paliperidone palmitate long acting injectables treatment: pooled analysis of two double-blind randomized phase three studies
Drug formulation: Easing the toll of caregiving Switching from oral to long-acting injectable antipsychotic medication improves overall caregiver burden. The physical, emotional and financial toll of providing care for patients with schizophrenia is often underestimated. Poor adherence to convention...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-07-01
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| Series: | npj Schizophrenia |
| Online Access: | https://doi.org/10.1038/s41537-017-0025-5 |
| _version_ | 1797428710563905536 |
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| author | Srihari Gopal Haiyan Xu Kelly McQuarrie Adam Savitz Isaac Nuamah Kimberly Woodruff Maju Mathews |
| author_facet | Srihari Gopal Haiyan Xu Kelly McQuarrie Adam Savitz Isaac Nuamah Kimberly Woodruff Maju Mathews |
| author_sort | Srihari Gopal |
| collection | DOAJ |
| description | Drug formulation: Easing the toll of caregiving Switching from oral to long-acting injectable antipsychotic medication improves overall caregiver burden. The physical, emotional and financial toll of providing care for patients with schizophrenia is often underestimated. Poor adherence to conventional oral antipsychotics is a major cause of symptomatic relapse in patients and of stress for carers. Srihari Gopal and colleagues at Janssen Pharmaceuticals have pooled data from two large studies involving 1498 caregivers across 27 countries. They found that administration of either 1- or 3-monthly long-acting injectable antipsychotics not only eased the burden of daily dosing and patient compliance, but also had a positive impact on the stress conditions of caregivers. Using the Involvement Evaluation Questionnaire to measure caregiver burden, the authors showed that the switch in drug formulation decreased the need to urge patients to self-care and the hours spent caregiving. |
| first_indexed | 2024-03-09T09:01:49Z |
| format | Article |
| id | doaj.art-174df3333f1542aba31699e1d40b0a99 |
| institution | Directory Open Access Journal |
| issn | 2334-265X |
| language | English |
| last_indexed | 2024-03-09T09:01:49Z |
| publishDate | 2017-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Schizophrenia |
| spelling | doaj.art-174df3333f1542aba31699e1d40b0a992023-12-02T11:14:08ZengNature Portfolionpj Schizophrenia2334-265X2017-07-01311610.1038/s41537-017-0025-5Caregiver burden in schizophrenia following paliperidone palmitate long acting injectables treatment: pooled analysis of two double-blind randomized phase three studiesSrihari Gopal0Haiyan Xu1Kelly McQuarrie2Adam Savitz3Isaac Nuamah4Kimberly Woodruff5Maju Mathews6Janssen Research & Development, LLCJanssen Research & Development, LLCJanssen Research & Development, LLCJanssen Research & Development, LLCJanssen Research & Development, LLCJanssen Scientific Affairs, LLCJanssen Scientific Affairs, LLCDrug formulation: Easing the toll of caregiving Switching from oral to long-acting injectable antipsychotic medication improves overall caregiver burden. The physical, emotional and financial toll of providing care for patients with schizophrenia is often underestimated. Poor adherence to conventional oral antipsychotics is a major cause of symptomatic relapse in patients and of stress for carers. Srihari Gopal and colleagues at Janssen Pharmaceuticals have pooled data from two large studies involving 1498 caregivers across 27 countries. They found that administration of either 1- or 3-monthly long-acting injectable antipsychotics not only eased the burden of daily dosing and patient compliance, but also had a positive impact on the stress conditions of caregivers. Using the Involvement Evaluation Questionnaire to measure caregiver burden, the authors showed that the switch in drug formulation decreased the need to urge patients to self-care and the hours spent caregiving.https://doi.org/10.1038/s41537-017-0025-5 |
| spellingShingle | Srihari Gopal Haiyan Xu Kelly McQuarrie Adam Savitz Isaac Nuamah Kimberly Woodruff Maju Mathews Caregiver burden in schizophrenia following paliperidone palmitate long acting injectables treatment: pooled analysis of two double-blind randomized phase three studies npj Schizophrenia |
| title | Caregiver burden in schizophrenia following paliperidone palmitate long acting injectables treatment: pooled analysis of two double-blind randomized phase three studies |
| title_full | Caregiver burden in schizophrenia following paliperidone palmitate long acting injectables treatment: pooled analysis of two double-blind randomized phase three studies |
| title_fullStr | Caregiver burden in schizophrenia following paliperidone palmitate long acting injectables treatment: pooled analysis of two double-blind randomized phase three studies |
| title_full_unstemmed | Caregiver burden in schizophrenia following paliperidone palmitate long acting injectables treatment: pooled analysis of two double-blind randomized phase three studies |
| title_short | Caregiver burden in schizophrenia following paliperidone palmitate long acting injectables treatment: pooled analysis of two double-blind randomized phase three studies |
| title_sort | caregiver burden in schizophrenia following paliperidone palmitate long acting injectables treatment pooled analysis of two double blind randomized phase three studies |
| url | https://doi.org/10.1038/s41537-017-0025-5 |
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