Dwell time and bloodstream infection incidence of umbilical venous catheterization in China
ABSTRACT Importance Central line‐associated bloodstream infection (CLABSI) is one of the most serious complications of central venous access devices. Reducing the risk of CLABSI is of utmost significance in efforts to improve neonatal mortality rates and enhance long‐term prognosis. Objective To det...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-12-01
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| Series: | Pediatric Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ped4.12403 |
| _version_ | 1797422277130715136 |
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| author | Xu Zheng Dan He Zixin Yang Lu Chen Min Jiang Yujie Qi Fei Qin Jie Yu Yaguang Peng Ling Liu Mingyan Hei |
| author_facet | Xu Zheng Dan He Zixin Yang Lu Chen Min Jiang Yujie Qi Fei Qin Jie Yu Yaguang Peng Ling Liu Mingyan Hei |
| author_sort | Xu Zheng |
| collection | DOAJ |
| description | ABSTRACT Importance Central line‐associated bloodstream infection (CLABSI) is one of the most serious complications of central venous access devices. Reducing the risk of CLABSI is of utmost significance in efforts to improve neonatal mortality rates and enhance long‐term prognosis. Objective To determine the dwell time and incidence of CLABSI of umbilical venous catheterization (UVC) for preterm infants in China. Methods Preterm infants with UVC admitted to 44 tertiary neonatal intensive care units in 24 provinces in China were enrolled. Study period was from November 2019 to August 2021. The end point of observations was 48 h after umbilical venous (UV) catheter removal. The primary outcomes were dwell time of UV catheter and UVC‐associated CLABSI. Data between infants with UV catheter dwell time ≤7 days and >7 days, and with birth weight (BW) ≤1000 g and >1000 g were compared. Results In total, 2172 neonates were enrolled (gestational age 30.0 ± 2.4 weeks, BW 1258.5 ± 392.8 g). The median UV catheter dwell time was 7 (6–10) days. The incidence of UVC‐associated CLABSI was 3.03/1000 UV catheter days. For infants with UV catheter dwell time ≤7 days and >7 days, the UVC‐associated CLABSI incidence was 3.71 and 2.65 per 1000 UV catheter days, respectively, P = 0.23. For infants with UVC dwell times of 3–6, 7–12, and 13–15 days, the UVC‐associated CLABSI rates were 0.14%, 0.68%, and 2.48% (P < 0.01). The Kaplan–Meier plot of UV catheter dwell time to CLABSI showed no difference between infants with BW ≤1000 g and >1000 g (P = 0.60). Interpretation The median dwell time of UV catheter was 7 days, and the incidence of UVC‐associated CLABSI was 3.03/1000 catheter days in China. The daily risk of UVC‐associated CLABSI and other complications increased with the dwell time. |
| first_indexed | 2024-03-09T07:29:53Z |
| format | Article |
| id | doaj.art-175130cc7a2248b6ad6b5cc17f1c2fcc |
| institution | Directory Open Access Journal |
| issn | 2574-2272 |
| language | English |
| last_indexed | 2024-03-09T07:29:53Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pediatric Investigation |
| spelling | doaj.art-175130cc7a2248b6ad6b5cc17f1c2fcc2023-12-03T06:24:55ZengWileyPediatric Investigation2574-22722023-12-017423924610.1002/ped4.12403Dwell time and bloodstream infection incidence of umbilical venous catheterization in ChinaXu Zheng0Dan He1Zixin Yang2Lu Chen3Min Jiang4Yujie Qi5Fei Qin6Jie Yu7Yaguang Peng8Ling Liu9Mingyan Hei10Neonatal Center, Beijing Children's Hospital, Capital Medical University National Center of Children's Health Beijing ChinaGuiyang Maternal and Child Health Care Hospital Guiyang Children's Hospital Guizhou ChinaNeonatal Center, Beijing Children's Hospital, Capital Medical University National Center of Children's Health Beijing ChinaNeonatal Center, Beijing Children's Hospital, Capital Medical University National Center of Children's Health Beijing ChinaNeonatal Center, Beijing Children's Hospital, Capital Medical University National Center of Children's Health Beijing ChinaNeonatal Center, Beijing Children's Hospital, Capital Medical University National Center of Children's Health Beijing ChinaNeonatal Center, Beijing Children's Hospital, Capital Medical University National Center of Children's Health Beijing ChinaNeonatal Center, Beijing Children's Hospital, Capital Medical University National Center of Children's Health Beijing ChinaCenter for Clinical Epidemiology and Evidence‐based Medicine, Beijing Children's Hospital, Capital Medical University National Center for Children's Health Beijing ChinaGuiyang Maternal and Child Health Care Hospital Guiyang Children's Hospital Guizhou ChinaNeonatal Center, Beijing Children's Hospital, Capital Medical University National Center of Children's Health Beijing ChinaABSTRACT Importance Central line‐associated bloodstream infection (CLABSI) is one of the most serious complications of central venous access devices. Reducing the risk of CLABSI is of utmost significance in efforts to improve neonatal mortality rates and enhance long‐term prognosis. Objective To determine the dwell time and incidence of CLABSI of umbilical venous catheterization (UVC) for preterm infants in China. Methods Preterm infants with UVC admitted to 44 tertiary neonatal intensive care units in 24 provinces in China were enrolled. Study period was from November 2019 to August 2021. The end point of observations was 48 h after umbilical venous (UV) catheter removal. The primary outcomes were dwell time of UV catheter and UVC‐associated CLABSI. Data between infants with UV catheter dwell time ≤7 days and >7 days, and with birth weight (BW) ≤1000 g and >1000 g were compared. Results In total, 2172 neonates were enrolled (gestational age 30.0 ± 2.4 weeks, BW 1258.5 ± 392.8 g). The median UV catheter dwell time was 7 (6–10) days. The incidence of UVC‐associated CLABSI was 3.03/1000 UV catheter days. For infants with UV catheter dwell time ≤7 days and >7 days, the UVC‐associated CLABSI incidence was 3.71 and 2.65 per 1000 UV catheter days, respectively, P = 0.23. For infants with UVC dwell times of 3–6, 7–12, and 13–15 days, the UVC‐associated CLABSI rates were 0.14%, 0.68%, and 2.48% (P < 0.01). The Kaplan–Meier plot of UV catheter dwell time to CLABSI showed no difference between infants with BW ≤1000 g and >1000 g (P = 0.60). Interpretation The median dwell time of UV catheter was 7 days, and the incidence of UVC‐associated CLABSI was 3.03/1000 catheter days in China. The daily risk of UVC‐associated CLABSI and other complications increased with the dwell time.https://doi.org/10.1002/ped4.12403Central lineDwell timeInfectionNewbornUmbilical |
| spellingShingle | Xu Zheng Dan He Zixin Yang Lu Chen Min Jiang Yujie Qi Fei Qin Jie Yu Yaguang Peng Ling Liu Mingyan Hei Dwell time and bloodstream infection incidence of umbilical venous catheterization in China Pediatric Investigation Central line Dwell time Infection Newborn Umbilical |
| title | Dwell time and bloodstream infection incidence of umbilical venous catheterization in China |
| title_full | Dwell time and bloodstream infection incidence of umbilical venous catheterization in China |
| title_fullStr | Dwell time and bloodstream infection incidence of umbilical venous catheterization in China |
| title_full_unstemmed | Dwell time and bloodstream infection incidence of umbilical venous catheterization in China |
| title_short | Dwell time and bloodstream infection incidence of umbilical venous catheterization in China |
| title_sort | dwell time and bloodstream infection incidence of umbilical venous catheterization in china |
| topic | Central line Dwell time Infection Newborn Umbilical |
| url | https://doi.org/10.1002/ped4.12403 |
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