MIR retrotransposons link the epigenome and the transcriptome of coding genes in acute myeloid leukemia
The links between DNA methylation and gene expression are poorly understood on large-scale. Here the authors show that MIR retrotransposons within introns can play this role in acute myeloid leukemia harbouring mutations in epigenetic modifiers.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34211-x |
| _version_ | 1798044287284281344 |
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| author | Aristeidis G. Telonis Qin Yang Hsuan-Ting Huang Maria E. Figueroa |
| author_facet | Aristeidis G. Telonis Qin Yang Hsuan-Ting Huang Maria E. Figueroa |
| author_sort | Aristeidis G. Telonis |
| collection | DOAJ |
| description | The links between DNA methylation and gene expression are poorly understood on large-scale. Here the authors show that MIR retrotransposons within introns can play this role in acute myeloid leukemia harbouring mutations in epigenetic modifiers. |
| first_indexed | 2024-04-11T23:01:21Z |
| format | Article |
| id | doaj.art-17513ffd013c4a1e988e526eaa792bc6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T23:01:21Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-17513ffd013c4a1e988e526eaa792bc62022-12-22T03:58:07ZengNature PortfolioNature Communications2041-17232022-10-0113111410.1038/s41467-022-34211-xMIR retrotransposons link the epigenome and the transcriptome of coding genes in acute myeloid leukemiaAristeidis G. Telonis0Qin Yang1Hsuan-Ting Huang2Maria E. Figueroa3Department of Biochemistry and Molecular Biology, University of Miami Miller School of MedicineDepartment of Biochemistry and Molecular Biology, University of Miami Miller School of MedicineDepartment of Biochemistry and Molecular Biology, University of Miami Miller School of MedicineDepartment of Biochemistry and Molecular Biology, University of Miami Miller School of MedicineThe links between DNA methylation and gene expression are poorly understood on large-scale. Here the authors show that MIR retrotransposons within introns can play this role in acute myeloid leukemia harbouring mutations in epigenetic modifiers.https://doi.org/10.1038/s41467-022-34211-x |
| spellingShingle | Aristeidis G. Telonis Qin Yang Hsuan-Ting Huang Maria E. Figueroa MIR retrotransposons link the epigenome and the transcriptome of coding genes in acute myeloid leukemia Nature Communications |
| title | MIR retrotransposons link the epigenome and the transcriptome of coding genes in acute myeloid leukemia |
| title_full | MIR retrotransposons link the epigenome and the transcriptome of coding genes in acute myeloid leukemia |
| title_fullStr | MIR retrotransposons link the epigenome and the transcriptome of coding genes in acute myeloid leukemia |
| title_full_unstemmed | MIR retrotransposons link the epigenome and the transcriptome of coding genes in acute myeloid leukemia |
| title_short | MIR retrotransposons link the epigenome and the transcriptome of coding genes in acute myeloid leukemia |
| title_sort | mir retrotransposons link the epigenome and the transcriptome of coding genes in acute myeloid leukemia |
| url | https://doi.org/10.1038/s41467-022-34211-x |
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