Imidazolium Salts for <i>Candida</i> spp. Antibiofilm High-Density Polyethylene-Based Biomaterials
The species of <i>Candida</i> present good capability to form fungal biofilms on polymeric surfaces and are related to several human diseases since many of the employed medical devices are designed using polymers, especially high-density polyethylene (HDPE). Herein, HDPE films containing...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/15/5/1259 |
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| author | Clarissa Martins Leal Schrekker Yuri Clemente Andrade Sokolovicz Maria Grazia Raucci Claudio Alberto Martins Leal Luigi Ambrosio Mário Lettieri Teixeira Alexandre Meneghello Fuentefria Henri Stephan Schrekker |
| author_facet | Clarissa Martins Leal Schrekker Yuri Clemente Andrade Sokolovicz Maria Grazia Raucci Claudio Alberto Martins Leal Luigi Ambrosio Mário Lettieri Teixeira Alexandre Meneghello Fuentefria Henri Stephan Schrekker |
| author_sort | Clarissa Martins Leal Schrekker |
| collection | DOAJ |
| description | The species of <i>Candida</i> present good capability to form fungal biofilms on polymeric surfaces and are related to several human diseases since many of the employed medical devices are designed using polymers, especially high-density polyethylene (HDPE). Herein, HDPE films containing 0; 0.125; 0.250 or 0.500 wt% of 1-hexadecyl-3-methylimidazolium chloride (C<sub>16</sub>MImCl) or its analog 1-hexadecyl-3-methylimidazolium methanesulfonate (C<sub>16</sub>MImMeS) were obtained by melt blending and posteriorly mechanically pressurized into films. This approach resulted in more flexible and less brittle films, which impeded the <i>Candida albicans, C. parapsilosis</i>, and <i>C. tropicalis</i> biofilm formation on their surfaces. The employed imidazolium salt (IS) concentrations did not present any significant cytotoxic effect, and the good cell adhesion/proliferation of human mesenchymal stem cells on the HDPE-IS films indicated good biocompatibility. These outcomes combined with the absence of microscopic lesions in pig skin after contact with HDPE-IS films demonstrated their potential as biomaterials for the development of effective medical device tools that reduce the risk of fungal infections. |
| first_indexed | 2024-03-11T07:12:42Z |
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| id | doaj.art-1751470bb17945fea3b71eddd90f6f0e |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-11T07:12:42Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-1751470bb17945fea3b71eddd90f6f0e2023-11-17T08:28:20ZengMDPI AGPolymers2073-43602023-03-01155125910.3390/polym15051259Imidazolium Salts for <i>Candida</i> spp. Antibiofilm High-Density Polyethylene-Based BiomaterialsClarissa Martins Leal Schrekker0Yuri Clemente Andrade Sokolovicz1Maria Grazia Raucci2Claudio Alberto Martins Leal3Luigi Ambrosio4Mário Lettieri Teixeira5Alexandre Meneghello Fuentefria6Henri Stephan Schrekker7Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul (UFRGS), Rua Sarmento Leite 500, Porto Alegre 90050-170, RS, BrazilLaboratory of Technological Processes and Catalysis, Institute of Chemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Avenida Bento Gonçalves 9500, Porto Alegre 91501-970, RS, BrazilInstitute of Polymers, Composites and Biomaterials, National Research Council of Italy (IPCB-CNR), Viale John Fitzgerald Kennedy 54, Mostra d’Oltremare Padiglione 20, 80125 Naples, ItalyLaboratory of Technological Processes and Catalysis, Institute of Chemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Avenida Bento Gonçalves 9500, Porto Alegre 91501-970, RS, BrazilInstitute of Polymers, Composites and Biomaterials, National Research Council of Italy (IPCB-CNR), Viale John Fitzgerald Kennedy 54, Mostra d’Oltremare Padiglione 20, 80125 Naples, ItalyLaboratory of Biochemistry and Toxicology, Instituto Federal Catarinense (IFC), Rodovia SC 283—km 17, Concórdia 89703-720, SC, BrazilInstitute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul (UFRGS), Rua Sarmento Leite 500, Porto Alegre 90050-170, RS, BrazilLaboratory of Technological Processes and Catalysis, Institute of Chemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Avenida Bento Gonçalves 9500, Porto Alegre 91501-970, RS, BrazilThe species of <i>Candida</i> present good capability to form fungal biofilms on polymeric surfaces and are related to several human diseases since many of the employed medical devices are designed using polymers, especially high-density polyethylene (HDPE). Herein, HDPE films containing 0; 0.125; 0.250 or 0.500 wt% of 1-hexadecyl-3-methylimidazolium chloride (C<sub>16</sub>MImCl) or its analog 1-hexadecyl-3-methylimidazolium methanesulfonate (C<sub>16</sub>MImMeS) were obtained by melt blending and posteriorly mechanically pressurized into films. This approach resulted in more flexible and less brittle films, which impeded the <i>Candida albicans, C. parapsilosis</i>, and <i>C. tropicalis</i> biofilm formation on their surfaces. The employed imidazolium salt (IS) concentrations did not present any significant cytotoxic effect, and the good cell adhesion/proliferation of human mesenchymal stem cells on the HDPE-IS films indicated good biocompatibility. These outcomes combined with the absence of microscopic lesions in pig skin after contact with HDPE-IS films demonstrated their potential as biomaterials for the development of effective medical device tools that reduce the risk of fungal infections.https://www.mdpi.com/2073-4360/15/5/1259ionic liquidhuman mesenchymal stem cellsbiocompatibilitymelt blendinghistopathological evaluation |
| spellingShingle | Clarissa Martins Leal Schrekker Yuri Clemente Andrade Sokolovicz Maria Grazia Raucci Claudio Alberto Martins Leal Luigi Ambrosio Mário Lettieri Teixeira Alexandre Meneghello Fuentefria Henri Stephan Schrekker Imidazolium Salts for <i>Candida</i> spp. Antibiofilm High-Density Polyethylene-Based Biomaterials Polymers ionic liquid human mesenchymal stem cells biocompatibility melt blending histopathological evaluation |
| title | Imidazolium Salts for <i>Candida</i> spp. Antibiofilm High-Density Polyethylene-Based Biomaterials |
| title_full | Imidazolium Salts for <i>Candida</i> spp. Antibiofilm High-Density Polyethylene-Based Biomaterials |
| title_fullStr | Imidazolium Salts for <i>Candida</i> spp. Antibiofilm High-Density Polyethylene-Based Biomaterials |
| title_full_unstemmed | Imidazolium Salts for <i>Candida</i> spp. Antibiofilm High-Density Polyethylene-Based Biomaterials |
| title_short | Imidazolium Salts for <i>Candida</i> spp. Antibiofilm High-Density Polyethylene-Based Biomaterials |
| title_sort | imidazolium salts for i candida i spp antibiofilm high density polyethylene based biomaterials |
| topic | ionic liquid human mesenchymal stem cells biocompatibility melt blending histopathological evaluation |
| url | https://www.mdpi.com/2073-4360/15/5/1259 |
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