Psychophysical properties of odour processing can be quantitatively described by relative AP latency patterns in mitral and tufted cells
Electrophysiological and population imaging data in rodents show that olfactory bulb(OB) activity is profoundly modulated by the odour sampling process while behavioralexperiments indicate that odour discrimination can occur within a single sniff. Thispaper addresses the question of whether action p...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-05-01
|
| Series: | Frontiers in Systems Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnsys.2012.00030/full |
| _version_ | 1818606229237268480 |
|---|---|
| author | Andreas T. Schaefer Andreas T. Schaefer Andreas T. Schaefer Troy W. Margrie Troy W. Margrie |
| author_facet | Andreas T. Schaefer Andreas T. Schaefer Andreas T. Schaefer Troy W. Margrie Troy W. Margrie |
| author_sort | Andreas T. Schaefer |
| collection | DOAJ |
| description | Electrophysiological and population imaging data in rodents show that olfactory bulb(OB) activity is profoundly modulated by the odour sampling process while behavioralexperiments indicate that odour discrimination can occur within a single sniff. Thispaper addresses the question of whether action potential (AP) latencies occurring acrossthe mitral and tufted cell (M/TC) population within an individual sampling cycle couldaccount for the psychophysical properties of odour processing. To determine this wecreated an OB model (50 000 M/TCs) exhibiting hallmarks of published in vivoproperties and used a template-matching algorithm to assess stimulus separation. Suchan AP latency-based scheme showed high reproducibility and sensitivity such that odourstimuli could be reliably separated independent of concentration. As in behavioralexperiments we found that very dissimilar odours (A vs B) were accurately andrapidly discerned while very similar odours (binary mixtures, 0.4A/0.6B vs 0.6A/0.4B)required up to 90 ms longer. As in lesion studies we find that AP latency-basedrepresentation is rather insensitive to disruption of large regions of the OB. The APlatency-based scheme described here therefore captures both temporal andpsychophysical properties of olfactory processing and suggests that the onset patterns ofM/TC activity in the OB represent stimulus specific features of olfactory stimuli. |
| first_indexed | 2024-12-16T14:07:32Z |
| format | Article |
| id | doaj.art-17517468d8bd48218197a9b890e9dd3a |
| institution | Directory Open Access Journal |
| issn | 1662-5137 |
| language | English |
| last_indexed | 2024-12-16T14:07:32Z |
| publishDate | 2012-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Systems Neuroscience |
| spelling | doaj.art-17517468d8bd48218197a9b890e9dd3a2022-12-21T22:28:52ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372012-05-01610.3389/fnsys.2012.0003021736Psychophysical properties of odour processing can be quantitatively described by relative AP latency patterns in mitral and tufted cellsAndreas T. Schaefer0Andreas T. Schaefer1Andreas T. Schaefer2Troy W. Margrie3Troy W. Margrie4University College LondonUniversität HeidelbergMPI for medical researchUniversity College LondonThe National Institute for Medical ResearchElectrophysiological and population imaging data in rodents show that olfactory bulb(OB) activity is profoundly modulated by the odour sampling process while behavioralexperiments indicate that odour discrimination can occur within a single sniff. Thispaper addresses the question of whether action potential (AP) latencies occurring acrossthe mitral and tufted cell (M/TC) population within an individual sampling cycle couldaccount for the psychophysical properties of odour processing. To determine this wecreated an OB model (50 000 M/TCs) exhibiting hallmarks of published in vivoproperties and used a template-matching algorithm to assess stimulus separation. Suchan AP latency-based scheme showed high reproducibility and sensitivity such that odourstimuli could be reliably separated independent of concentration. As in behavioralexperiments we found that very dissimilar odours (A vs B) were accurately andrapidly discerned while very similar odours (binary mixtures, 0.4A/0.6B vs 0.6A/0.4B)required up to 90 ms longer. As in lesion studies we find that AP latency-basedrepresentation is rather insensitive to disruption of large regions of the OB. The APlatency-based scheme described here therefore captures both temporal andpsychophysical properties of olfactory processing and suggests that the onset patterns ofM/TC activity in the OB represent stimulus specific features of olfactory stimuli.http://journal.frontiersin.org/Journal/10.3389/fnsys.2012.00030/fullin vivoOlfactionModelbehaviourdiscrimination timeslatency code |
| spellingShingle | Andreas T. Schaefer Andreas T. Schaefer Andreas T. Schaefer Troy W. Margrie Troy W. Margrie Psychophysical properties of odour processing can be quantitatively described by relative AP latency patterns in mitral and tufted cells Frontiers in Systems Neuroscience in vivo Olfaction Model behaviour discrimination times latency code |
| title | Psychophysical properties of odour processing can be quantitatively described by relative AP latency patterns in mitral and tufted cells |
| title_full | Psychophysical properties of odour processing can be quantitatively described by relative AP latency patterns in mitral and tufted cells |
| title_fullStr | Psychophysical properties of odour processing can be quantitatively described by relative AP latency patterns in mitral and tufted cells |
| title_full_unstemmed | Psychophysical properties of odour processing can be quantitatively described by relative AP latency patterns in mitral and tufted cells |
| title_short | Psychophysical properties of odour processing can be quantitatively described by relative AP latency patterns in mitral and tufted cells |
| title_sort | psychophysical properties of odour processing can be quantitatively described by relative ap latency patterns in mitral and tufted cells |
| topic | in vivo Olfaction Model behaviour discrimination times latency code |
| url | http://journal.frontiersin.org/Journal/10.3389/fnsys.2012.00030/full |
| work_keys_str_mv | AT andreastschaefer psychophysicalpropertiesofodourprocessingcanbequantitativelydescribedbyrelativeaplatencypatternsinmitralandtuftedcells AT andreastschaefer psychophysicalpropertiesofodourprocessingcanbequantitativelydescribedbyrelativeaplatencypatternsinmitralandtuftedcells AT andreastschaefer psychophysicalpropertiesofodourprocessingcanbequantitativelydescribedbyrelativeaplatencypatternsinmitralandtuftedcells AT troywmargrie psychophysicalpropertiesofodourprocessingcanbequantitativelydescribedbyrelativeaplatencypatternsinmitralandtuftedcells AT troywmargrie psychophysicalpropertiesofodourprocessingcanbequantitativelydescribedbyrelativeaplatencypatternsinmitralandtuftedcells |