Immune Checkpoints in Solid Organ Transplantation
Allogenic graft acceptance is only achieved by life-long immunosuppression, which comes at the cost of significant toxicity. Clinicians face the challenge of adapting the patients’ treatments over long periods to lower the risks associated with these toxicities, permanently leveraging the risk of ex...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/12/10/1358 |
| _version_ | 1827721564098920448 |
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| author | Arnaud Del Bello Emmanuel Treiner |
| author_facet | Arnaud Del Bello Emmanuel Treiner |
| author_sort | Arnaud Del Bello |
| collection | DOAJ |
| description | Allogenic graft acceptance is only achieved by life-long immunosuppression, which comes at the cost of significant toxicity. Clinicians face the challenge of adapting the patients’ treatments over long periods to lower the risks associated with these toxicities, permanently leveraging the risk of excessive versus insufficient immunosuppression. A major goal and challenge in the field of solid organ transplantation (SOT) is to attain a state of stable immune tolerance specifically towards the grafted organ. The immune system is equipped with a set of inhibitory co-receptors known as immune checkpoints (ICs), which physiologically regulate numerous effector functions. Insufficient regulation through these ICs can lead to autoimmunity and/or immune-mediated toxicity, while excessive expression of ICs induces stable hypo-responsiveness, especially in T cells, a state sometimes referred to as exhaustion. IC blockade has emerged in the last decade as a powerful therapeutic tool against cancer. The opposite action, i.e., subverting IC for the benefit of establishing a state of specific hypo-responsiveness against auto- or allo-antigens, is still in its infancy. In this review, we will summarize the available literature on the role of ICs in SOT and the relevance of ICs with graft acceptance. We will also discuss the possible influence of current immunosuppressive medications on IC functions. |
| first_indexed | 2024-03-10T21:25:10Z |
| format | Article |
| id | doaj.art-17526aa592ab4a19adb91c653fd5b7f2 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T21:25:10Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-17526aa592ab4a19adb91c653fd5b7f22023-11-19T15:44:11ZengMDPI AGBiology2079-77372023-10-011210135810.3390/biology12101358Immune Checkpoints in Solid Organ TransplantationArnaud Del Bello0Emmanuel Treiner1Department of Nephrology, University Hospital of Toulouse, 31400 Toulouse, FranceFaculty of Medicine, University Toulouse III Paul Sabatier, 31062 Toulouse, FranceAllogenic graft acceptance is only achieved by life-long immunosuppression, which comes at the cost of significant toxicity. Clinicians face the challenge of adapting the patients’ treatments over long periods to lower the risks associated with these toxicities, permanently leveraging the risk of excessive versus insufficient immunosuppression. A major goal and challenge in the field of solid organ transplantation (SOT) is to attain a state of stable immune tolerance specifically towards the grafted organ. The immune system is equipped with a set of inhibitory co-receptors known as immune checkpoints (ICs), which physiologically regulate numerous effector functions. Insufficient regulation through these ICs can lead to autoimmunity and/or immune-mediated toxicity, while excessive expression of ICs induces stable hypo-responsiveness, especially in T cells, a state sometimes referred to as exhaustion. IC blockade has emerged in the last decade as a powerful therapeutic tool against cancer. The opposite action, i.e., subverting IC for the benefit of establishing a state of specific hypo-responsiveness against auto- or allo-antigens, is still in its infancy. In this review, we will summarize the available literature on the role of ICs in SOT and the relevance of ICs with graft acceptance. We will also discuss the possible influence of current immunosuppressive medications on IC functions.https://www.mdpi.com/2079-7737/12/10/1358immune checkpointsorgan transplantationtoleranceimmunotherapy |
| spellingShingle | Arnaud Del Bello Emmanuel Treiner Immune Checkpoints in Solid Organ Transplantation Biology immune checkpoints organ transplantation tolerance immunotherapy |
| title | Immune Checkpoints in Solid Organ Transplantation |
| title_full | Immune Checkpoints in Solid Organ Transplantation |
| title_fullStr | Immune Checkpoints in Solid Organ Transplantation |
| title_full_unstemmed | Immune Checkpoints in Solid Organ Transplantation |
| title_short | Immune Checkpoints in Solid Organ Transplantation |
| title_sort | immune checkpoints in solid organ transplantation |
| topic | immune checkpoints organ transplantation tolerance immunotherapy |
| url | https://www.mdpi.com/2079-7737/12/10/1358 |
| work_keys_str_mv | AT arnauddelbello immunecheckpointsinsolidorgantransplantation AT emmanueltreiner immunecheckpointsinsolidorgantransplantation |