Cerebrospinal Fluid and Microdialysis Cytokines in Aneurysmal Subarachnoid Hemorrhage: A Scoping Systematic Review
ObjectiveTo perform two scoping systematic reviews of the literature on cytokine measurement in cerebral microdialysis (CMD) and cerebrospinal fluid (CSF) in aneurysmal subarachnoid hemorrhage (SAH) patients, aiming to summarize the evidence relating cytokine levels to pathophysiology, disease progr...
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Frontiers Media S.A.
2017-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fneur.2017.00379/full |
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| author | Frederick A. Zeiler Frederick A. Zeiler Frederick A. Zeiler Eric Peter Thelin Eric Peter Thelin Marek Czosnyka Peter J. Hutchinson David K. Menon Adel Helmy |
| author_facet | Frederick A. Zeiler Frederick A. Zeiler Frederick A. Zeiler Eric Peter Thelin Eric Peter Thelin Marek Czosnyka Peter J. Hutchinson David K. Menon Adel Helmy |
| author_sort | Frederick A. Zeiler |
| collection | DOAJ |
| description | ObjectiveTo perform two scoping systematic reviews of the literature on cytokine measurement in cerebral microdialysis (CMD) and cerebrospinal fluid (CSF) in aneurysmal subarachnoid hemorrhage (SAH) patients, aiming to summarize the evidence relating cytokine levels to pathophysiology, disease progression, and outcome.MethodsTwo separate systematic reviews were conducted: one for CMD cytokines and the second for CSF cytokines.Data sourcesArticles from MEDLINE, BIOSIS, EMBASE, Global Health, Scopus, Cochrane Library (inception to October 2016), reference lists of relevant articles, and gray literature were searched.Study selectionTwo reviewers independently identified all manuscripts utilizing predefined inclusion/exclusion criteria. A two-tier filter of references was conducted.Data extractionPatient demographic and study data were extracted to tables.ResultsThere were 9 studies identified describing the analysis of cytokines via CMD in 246 aneurysmal SAH patients. Similarly, 20 studies were identified describing the analysis of CSF cytokines in 630 patients. The two scoping systematic reviews demonstrated the following: (1) limited literature available on CMD cytokine measurement in aneurysmal SAH with some preliminary data supporting feasibility of measurement and potential association between interleukin (IL)-6 and patient outcome. (2) Various CSF measured cytokines may be associated with patient outcome at 3–6 months, including IL-1ra, IL-6, IL-8, and tumor necrosis factor-alpha. (3) There is a small literature body supporting an association between acute/subacute CSF transforming growth factor levels and the development of chronic hydrocephalus at 2–3 months.ConclusionThe evaluation of CMD and CSF cytokines is an emerging area of the literature in aneurysmal SAH. Further large prospective multicenter studies on cytokines in CMD and CSF need to be conducted. |
| first_indexed | 2024-12-21T03:16:52Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-21T03:16:52Z |
| publishDate | 2017-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-17543058593748669eefa9286ae9012a2022-12-21T19:17:48ZengFrontiers Media S.A.Frontiers in Neurology1664-22952017-08-01810.3389/fneur.2017.00379274762Cerebrospinal Fluid and Microdialysis Cytokines in Aneurysmal Subarachnoid Hemorrhage: A Scoping Systematic ReviewFrederick A. Zeiler0Frederick A. Zeiler1Frederick A. Zeiler2Eric Peter Thelin3Eric Peter Thelin4Marek Czosnyka5Peter J. Hutchinson6David K. Menon7Adel Helmy8Rady Faculty of Health Sciences, Department of Surgery, University of Manitoba, Winnipeg, MB, CanadaClinician Investigator Program, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, CanadaDepartment of Anesthesia, Addenbrooke’s Hospital, University of Cambridge, Cambridge, United KingdomDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United KingdomDepartment of Clinical Neuroscience, Karolinska Institute, Stockholm, SwedenDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United KingdomDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United KingdomDepartment of Anesthesia, Addenbrooke’s Hospital, University of Cambridge, Cambridge, United KingdomDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United KingdomObjectiveTo perform two scoping systematic reviews of the literature on cytokine measurement in cerebral microdialysis (CMD) and cerebrospinal fluid (CSF) in aneurysmal subarachnoid hemorrhage (SAH) patients, aiming to summarize the evidence relating cytokine levels to pathophysiology, disease progression, and outcome.MethodsTwo separate systematic reviews were conducted: one for CMD cytokines and the second for CSF cytokines.Data sourcesArticles from MEDLINE, BIOSIS, EMBASE, Global Health, Scopus, Cochrane Library (inception to October 2016), reference lists of relevant articles, and gray literature were searched.Study selectionTwo reviewers independently identified all manuscripts utilizing predefined inclusion/exclusion criteria. A two-tier filter of references was conducted.Data extractionPatient demographic and study data were extracted to tables.ResultsThere were 9 studies identified describing the analysis of cytokines via CMD in 246 aneurysmal SAH patients. Similarly, 20 studies were identified describing the analysis of CSF cytokines in 630 patients. The two scoping systematic reviews demonstrated the following: (1) limited literature available on CMD cytokine measurement in aneurysmal SAH with some preliminary data supporting feasibility of measurement and potential association between interleukin (IL)-6 and patient outcome. (2) Various CSF measured cytokines may be associated with patient outcome at 3–6 months, including IL-1ra, IL-6, IL-8, and tumor necrosis factor-alpha. (3) There is a small literature body supporting an association between acute/subacute CSF transforming growth factor levels and the development of chronic hydrocephalus at 2–3 months.ConclusionThe evaluation of CMD and CSF cytokines is an emerging area of the literature in aneurysmal SAH. Further large prospective multicenter studies on cytokines in CMD and CSF need to be conducted.http://journal.frontiersin.org/article/10.3389/fneur.2017.00379/fullsubarachnoid hemorrhagesystematic reviewcytokinescerebrospinal fluidmicordialysis |
| spellingShingle | Frederick A. Zeiler Frederick A. Zeiler Frederick A. Zeiler Eric Peter Thelin Eric Peter Thelin Marek Czosnyka Peter J. Hutchinson David K. Menon Adel Helmy Cerebrospinal Fluid and Microdialysis Cytokines in Aneurysmal Subarachnoid Hemorrhage: A Scoping Systematic Review Frontiers in Neurology subarachnoid hemorrhage systematic review cytokines cerebrospinal fluid micordialysis |
| title | Cerebrospinal Fluid and Microdialysis Cytokines in Aneurysmal Subarachnoid Hemorrhage: A Scoping Systematic Review |
| title_full | Cerebrospinal Fluid and Microdialysis Cytokines in Aneurysmal Subarachnoid Hemorrhage: A Scoping Systematic Review |
| title_fullStr | Cerebrospinal Fluid and Microdialysis Cytokines in Aneurysmal Subarachnoid Hemorrhage: A Scoping Systematic Review |
| title_full_unstemmed | Cerebrospinal Fluid and Microdialysis Cytokines in Aneurysmal Subarachnoid Hemorrhage: A Scoping Systematic Review |
| title_short | Cerebrospinal Fluid and Microdialysis Cytokines in Aneurysmal Subarachnoid Hemorrhage: A Scoping Systematic Review |
| title_sort | cerebrospinal fluid and microdialysis cytokines in aneurysmal subarachnoid hemorrhage a scoping systematic review |
| topic | subarachnoid hemorrhage systematic review cytokines cerebrospinal fluid micordialysis |
| url | http://journal.frontiersin.org/article/10.3389/fneur.2017.00379/full |
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