Earliest observation of the tetracycline destructase tet(X3)
ABSTRACTTigecycline is an antibiotic of last resort for infections with carbapenem-resistant Acinetobacter baumannii. Plasmids harboring variants of the tetracycline destructase gene tetX promote rising tigecycline resistance rates. We report the earliest observation of tet(X3) in a clinical strain...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2024-04-01
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| Series: | Microbiology Spectrum |
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| Online Access: | https://journals.asm.org/doi/10.1128/spectrum.03327-23 |
| _version_ | 1827297810090819584 |
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| author | Frédéric Grenier Simon Lévesque Sébastien Rodrigue Louis-Patrick Haraoui |
| author_facet | Frédéric Grenier Simon Lévesque Sébastien Rodrigue Louis-Patrick Haraoui |
| author_sort | Frédéric Grenier |
| collection | DOAJ |
| description | ABSTRACTTigecycline is an antibiotic of last resort for infections with carbapenem-resistant Acinetobacter baumannii. Plasmids harboring variants of the tetracycline destructase gene tetX promote rising tigecycline resistance rates. We report the earliest observation of tet(X3) in a clinical strain predating tigecycline’s commercialization, suggesting selective pressures other than tigecycline contributed to its emergence.IMPORTANCEWe present the earliest observation of a tet(X3)-positive bacterial strain, predating by many years the earliest reports of this gene so far. This finding is significant as tigecycline is an antibiotic of last resort for carbapenem-resistant Acinetobacter baumannii (CRAB), which the World Health Organization ranks as one of its top three critical priority pathogens, and tet(X3) variants have become the most prevalent genes responsible for enabling CRAB to become tigecycline resistant. Moreover, the tet(X3)-positive strain we report is the first and only to be found that predates the commercialization of tigecycline, an antibiotic that was thought to have contributed to the emergence of this resistance gene. Understanding the factors contributing to the origin and spread of novel antibiotic resistance genes is crucial to addressing the major global public health issue, which is antimicrobial resistance. |
| first_indexed | 2024-04-24T15:02:47Z |
| format | Article |
| id | doaj.art-1757d7bf9f8140f08ddaef607de52ffb |
| institution | Directory Open Access Journal |
| issn | 2165-0497 |
| language | English |
| last_indexed | 2024-04-24T15:02:47Z |
| publishDate | 2024-04-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | Microbiology Spectrum |
| spelling | doaj.art-1757d7bf9f8140f08ddaef607de52ffb2024-04-02T14:16:17ZengAmerican Society for MicrobiologyMicrobiology Spectrum2165-04972024-04-0112410.1128/spectrum.03327-23Earliest observation of the tetracycline destructase tet(X3)Frédéric Grenier0Simon Lévesque1Sébastien Rodrigue2Louis-Patrick Haraoui3Department of Biology, Université de Sherbrooke, Sherbrooke, Québec, CanadaDepartment of Microbiology and Infectious Diseases, Université de Sherbrooke, Sherbrooke, Québec, CanadaDepartment of Biology, Université de Sherbrooke, Sherbrooke, Québec, CanadaDepartment of Microbiology and Infectious Diseases, Université de Sherbrooke, Sherbrooke, Québec, CanadaABSTRACTTigecycline is an antibiotic of last resort for infections with carbapenem-resistant Acinetobacter baumannii. Plasmids harboring variants of the tetracycline destructase gene tetX promote rising tigecycline resistance rates. We report the earliest observation of tet(X3) in a clinical strain predating tigecycline’s commercialization, suggesting selective pressures other than tigecycline contributed to its emergence.IMPORTANCEWe present the earliest observation of a tet(X3)-positive bacterial strain, predating by many years the earliest reports of this gene so far. This finding is significant as tigecycline is an antibiotic of last resort for carbapenem-resistant Acinetobacter baumannii (CRAB), which the World Health Organization ranks as one of its top three critical priority pathogens, and tet(X3) variants have become the most prevalent genes responsible for enabling CRAB to become tigecycline resistant. Moreover, the tet(X3)-positive strain we report is the first and only to be found that predates the commercialization of tigecycline, an antibiotic that was thought to have contributed to the emergence of this resistance gene. Understanding the factors contributing to the origin and spread of novel antibiotic resistance genes is crucial to addressing the major global public health issue, which is antimicrobial resistance.https://journals.asm.org/doi/10.1128/spectrum.03327-23antimicrobial resistancetetracycline destructasetet(X3)blaOXA-58Acinetobacter juniiIsrael |
| spellingShingle | Frédéric Grenier Simon Lévesque Sébastien Rodrigue Louis-Patrick Haraoui Earliest observation of the tetracycline destructase tet(X3) Microbiology Spectrum antimicrobial resistance tetracycline destructase tet(X3) blaOXA-58 Acinetobacter junii Israel |
| title | Earliest observation of the tetracycline destructase tet(X3) |
| title_full | Earliest observation of the tetracycline destructase tet(X3) |
| title_fullStr | Earliest observation of the tetracycline destructase tet(X3) |
| title_full_unstemmed | Earliest observation of the tetracycline destructase tet(X3) |
| title_short | Earliest observation of the tetracycline destructase tet(X3) |
| title_sort | earliest observation of the tetracycline destructase tet x3 |
| topic | antimicrobial resistance tetracycline destructase tet(X3) blaOXA-58 Acinetobacter junii Israel |
| url | https://journals.asm.org/doi/10.1128/spectrum.03327-23 |
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