Real-time monitoring of ultra-high dose rate electron beams using bremsstrahlung photons
Recently, as the clinically positive biological effects of ultra-high dose rate (UHDR) radiation beams have been revealed, interest in flash radiation therapy has increased. Generally, FLASH preclinical experiments are performed using UHDR electron beams generated by linear accelerators. Real-time m...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Nuclear Engineering and Technology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1738573323002607 |
| _version_ | 1797737331566837760 |
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| author | Hyun Kim Dong Hyeok Jeong Sang Koo Kang Manwoo Lee Heuijin Lim Sang Jin Lee Kyoung Won Jang |
| author_facet | Hyun Kim Dong Hyeok Jeong Sang Koo Kang Manwoo Lee Heuijin Lim Sang Jin Lee Kyoung Won Jang |
| author_sort | Hyun Kim |
| collection | DOAJ |
| description | Recently, as the clinically positive biological effects of ultra-high dose rate (UHDR) radiation beams have been revealed, interest in flash radiation therapy has increased. Generally, FLASH preclinical experiments are performed using UHDR electron beams generated by linear accelerators. Real-time monitoring of UHDR beams is required to deliver the correct dose to a sample. However, it is difficult to use typical transmission-type ionization chambers for primary beam monitoring because there is no suitable electrometer capable of reading high pulsed currents, and collection efficiency is drastically reduced in pulsed radiation beams with ultra-high doses. In this study, a monitoring method using bremsstrahlung photons generated by irradiation devices and a water phantom was proposed. Charges collected in an ionization chamber located at the back of a water phantom were analyzed using the bremsstrahlung tail on electron depth dose curves obtained using radiochromic films. The dose conversion factor for converting a monitored charge into a delivered dose was determined analytically for the Advanced Markus® chamber and compared with experimentally determined values. It is anticipated that the method proposed in this study can be useful for monitoring sample doses in UHDR electron beam irradiation. |
| first_indexed | 2024-03-12T13:27:08Z |
| format | Article |
| id | doaj.art-17585611cddc418a969b429ebee09cc5 |
| institution | Directory Open Access Journal |
| issn | 1738-5733 |
| language | English |
| last_indexed | 2024-03-12T13:27:08Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Nuclear Engineering and Technology |
| spelling | doaj.art-17585611cddc418a969b429ebee09cc52023-08-25T04:24:02ZengElsevierNuclear Engineering and Technology1738-57332023-09-0155934173422Real-time monitoring of ultra-high dose rate electron beams using bremsstrahlung photonsHyun Kim0Dong Hyeok Jeong1Sang Koo Kang2Manwoo Lee3Heuijin Lim4Sang Jin Lee5Kyoung Won Jang6Research Center, Dongnam Institute of Radiological & Medical Sciences, Busan, 46033, South KoreaResearch Center, Dongnam Institute of Radiological & Medical Sciences, Busan, 46033, South KoreaResearch Center, Dongnam Institute of Radiological & Medical Sciences, Busan, 46033, South KoreaResearch Center, Dongnam Institute of Radiological & Medical Sciences, Busan, 46033, South KoreaResearch Center, Dongnam Institute of Radiological & Medical Sciences, Busan, 46033, South KoreaResearch Center, Dongnam Institute of Radiological & Medical Sciences, Busan, 46033, South KoreaCorresponding author.; Research Center, Dongnam Institute of Radiological & Medical Sciences, Busan, 46033, South KoreaRecently, as the clinically positive biological effects of ultra-high dose rate (UHDR) radiation beams have been revealed, interest in flash radiation therapy has increased. Generally, FLASH preclinical experiments are performed using UHDR electron beams generated by linear accelerators. Real-time monitoring of UHDR beams is required to deliver the correct dose to a sample. However, it is difficult to use typical transmission-type ionization chambers for primary beam monitoring because there is no suitable electrometer capable of reading high pulsed currents, and collection efficiency is drastically reduced in pulsed radiation beams with ultra-high doses. In this study, a monitoring method using bremsstrahlung photons generated by irradiation devices and a water phantom was proposed. Charges collected in an ionization chamber located at the back of a water phantom were analyzed using the bremsstrahlung tail on electron depth dose curves obtained using radiochromic films. The dose conversion factor for converting a monitored charge into a delivered dose was determined analytically for the Advanced Markus® chamber and compared with experimentally determined values. It is anticipated that the method proposed in this study can be useful for monitoring sample doses in UHDR electron beam irradiation.http://www.sciencedirect.com/science/article/pii/S1738573323002607UHDR electron BeamsReal-time monitoringIonization chamberFLASH radiotherapy |
| spellingShingle | Hyun Kim Dong Hyeok Jeong Sang Koo Kang Manwoo Lee Heuijin Lim Sang Jin Lee Kyoung Won Jang Real-time monitoring of ultra-high dose rate electron beams using bremsstrahlung photons Nuclear Engineering and Technology UHDR electron Beams Real-time monitoring Ionization chamber FLASH radiotherapy |
| title | Real-time monitoring of ultra-high dose rate electron beams using bremsstrahlung photons |
| title_full | Real-time monitoring of ultra-high dose rate electron beams using bremsstrahlung photons |
| title_fullStr | Real-time monitoring of ultra-high dose rate electron beams using bremsstrahlung photons |
| title_full_unstemmed | Real-time monitoring of ultra-high dose rate electron beams using bremsstrahlung photons |
| title_short | Real-time monitoring of ultra-high dose rate electron beams using bremsstrahlung photons |
| title_sort | real time monitoring of ultra high dose rate electron beams using bremsstrahlung photons |
| topic | UHDR electron Beams Real-time monitoring Ionization chamber FLASH radiotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S1738573323002607 |
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