Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix
Severe Acute Respiratory Syndrome Coronavirus 2 is the third highly pathogenic human coronavirus in history. Since the emergence in Hubei province, China, during late 2019, the situation evolved to pandemic level. Following China, Europe was the second epicenter of the pandemic. To better comprehend...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/12/12/1401 |
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| author | Gábor Kemenesi Safia Zeghbib Balázs A Somogyi Gábor Endre Tóth Krisztián Bányai Norbert Solymosi Peter M Szabo István Szabó Ádám Bálint Péter Urbán Róbert Herczeg Attila Gyenesei Ágnes Nagy Csaba István Pereszlényi Gergely Csaba Babinszky Gábor Dudás Gabriella Terhes Viktor Zöldi Róbert Lovas Szabolcs Tenczer László Kornya Ferenc Jakab |
| author_facet | Gábor Kemenesi Safia Zeghbib Balázs A Somogyi Gábor Endre Tóth Krisztián Bányai Norbert Solymosi Peter M Szabo István Szabó Ádám Bálint Péter Urbán Róbert Herczeg Attila Gyenesei Ágnes Nagy Csaba István Pereszlényi Gergely Csaba Babinszky Gábor Dudás Gabriella Terhes Viktor Zöldi Róbert Lovas Szabolcs Tenczer László Kornya Ferenc Jakab |
| author_sort | Gábor Kemenesi |
| collection | DOAJ |
| description | Severe Acute Respiratory Syndrome Coronavirus 2 is the third highly pathogenic human coronavirus in history. Since the emergence in Hubei province, China, during late 2019, the situation evolved to pandemic level. Following China, Europe was the second epicenter of the pandemic. To better comprehend the detailed founder mechanisms of the epidemic evolution in Central-Eastern Europe, particularly in Hungary, we determined the full-length SARS-CoV-2 genomes from 32 clinical samples collected from laboratory confirmed COVID-19 patients over the first month of disease in Hungary. We applied a haplotype network analysis on all available complete genomic sequences of SARS-CoV-2 from GISAID database as of 21 April 2020. We performed additional phylogenetic and phylogeographic analyses to achieve the recognition of multiple and parallel introductory events into our region. Here, we present a publicly available network imaging of the worldwide haplotype relations of SARS-CoV-2 sequences and conclude the founder mechanisms of the outbreak in Central-Eastern Europe. |
| first_indexed | 2024-03-09T06:00:53Z |
| format | Article |
| id | doaj.art-175a02c738704eeaa235c743bc3378f6 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T06:00:53Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-175a02c738704eeaa235c743bc3378f62023-12-03T12:09:19ZengMDPI AGViruses1999-49152020-12-011212140110.3390/v12121401Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-MatrixGábor Kemenesi0Safia Zeghbib1Balázs A Somogyi2Gábor Endre Tóth3Krisztián Bányai4Norbert Solymosi5Peter M Szabo6István Szabó7Ádám Bálint8Péter Urbán9Róbert Herczeg10Attila Gyenesei11Ágnes Nagy12Csaba István Pereszlényi13Gergely Csaba Babinszky14Gábor Dudás15Gabriella Terhes16Viktor Zöldi17Róbert Lovas18Szabolcs Tenczer19László Kornya20Ferenc Jakab21National Laboratory of Virology, Szentágothai Research Centre, University of Pécs, 7624 Pécs, HungaryNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, 7624 Pécs, HungaryNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, 7624 Pécs, HungaryNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, 7624 Pécs, HungaryInstitute for Veterinary Medical Research, Centre for Agricultural Research, 1093 Budapest, HungaryCentre for Bioinformatics, University of Veterinary Medicine Budapest, 1078 Budapest, HungaryTranslational Discovery, Stromal Biology, Bristol-Myers Squibb, Princeton, NJ 08648, USAVeterinary Diagnostic Directorate, National Food Safety Office, 1143 Budapest, HungaryVeterinary Diagnostic Directorate, National Food Safety Office, 1143 Budapest, HungaryBioinformatics Research Group, Genomics and Bioinformatics Core Facility, Szentágothai Research Centre, University of Pécs, 7624 Pécs, HungaryBioinformatics Research Group, Genomics and Bioinformatics Core Facility, Szentágothai Research Centre, University of Pécs, 7624 Pécs, HungaryBioinformatics Research Group, Genomics and Bioinformatics Core Facility, Szentágothai Research Centre, University of Pécs, 7624 Pécs, HungaryMedical Centre, Hungarian Defense Forces, 1114 Budapest, HungaryMedical Centre, Hungarian Defense Forces, 1114 Budapest, HungaryMedical Centre, Hungarian Defense Forces, 1114 Budapest, HungaryMedical Centre, Hungarian Defense Forces, 1114 Budapest, HungaryInstitute of Clinical Microbiology, Faculty of Medicine, University of Szeged, 6720 Szeged, HungaryIndependent Researcher, 1301 Vantaa, FinlandInstitute for Computer Science and Control (SZTAKI), Eötvös Loránd Research Network, 1111 Budapest, HungaryInstitute for Computer Science and Control (SZTAKI), Eötvös Loránd Research Network, 1111 Budapest, HungaryCentral Hospital of Southern Pest—National Institute of Hematolgy and Infectious Diseases, 1476 Budapest, HungaryNational Laboratory of Virology, Szentágothai Research Centre, University of Pécs, 7624 Pécs, HungarySevere Acute Respiratory Syndrome Coronavirus 2 is the third highly pathogenic human coronavirus in history. Since the emergence in Hubei province, China, during late 2019, the situation evolved to pandemic level. Following China, Europe was the second epicenter of the pandemic. To better comprehend the detailed founder mechanisms of the epidemic evolution in Central-Eastern Europe, particularly in Hungary, we determined the full-length SARS-CoV-2 genomes from 32 clinical samples collected from laboratory confirmed COVID-19 patients over the first month of disease in Hungary. We applied a haplotype network analysis on all available complete genomic sequences of SARS-CoV-2 from GISAID database as of 21 April 2020. We performed additional phylogenetic and phylogeographic analyses to achieve the recognition of multiple and parallel introductory events into our region. Here, we present a publicly available network imaging of the worldwide haplotype relations of SARS-CoV-2 sequences and conclude the founder mechanisms of the outbreak in Central-Eastern Europe.https://www.mdpi.com/1999-4915/12/12/1401phylodynamicsnetwork analysisSARS-CoV-2human coronaviruspandemicoutbreak |
| spellingShingle | Gábor Kemenesi Safia Zeghbib Balázs A Somogyi Gábor Endre Tóth Krisztián Bányai Norbert Solymosi Peter M Szabo István Szabó Ádám Bálint Péter Urbán Róbert Herczeg Attila Gyenesei Ágnes Nagy Csaba István Pereszlényi Gergely Csaba Babinszky Gábor Dudás Gabriella Terhes Viktor Zöldi Róbert Lovas Szabolcs Tenczer László Kornya Ferenc Jakab Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix Viruses phylodynamics network analysis SARS-CoV-2 human coronavirus pandemic outbreak |
| title | Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix |
| title_full | Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix |
| title_fullStr | Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix |
| title_full_unstemmed | Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix |
| title_short | Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix |
| title_sort | multiple sars cov 2 introductions shaped the early outbreak in central eastern europe comparing hungarian data to a worldwide sequence data matrix |
| topic | phylodynamics network analysis SARS-CoV-2 human coronavirus pandemic outbreak |
| url | https://www.mdpi.com/1999-4915/12/12/1401 |
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