Pathological Features and Prognostication in Colorectal Cancer
The prognostication of colorectal cancer (CRC) has traditionally relied on staging as defined by the Union for International Cancer Control (UICC) and American Joint Committee on Cancer (AJCC) TNM staging classifications. However, clinically, there appears to be differences in survival patterns inde...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/28/6/447 |
| _version_ | 1797505511087669248 |
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| author | Kabytto Chen Geoffrey Collins Henry Wang James Wei Tatt Toh |
| author_facet | Kabytto Chen Geoffrey Collins Henry Wang James Wei Tatt Toh |
| author_sort | Kabytto Chen |
| collection | DOAJ |
| description | The prognostication of colorectal cancer (CRC) has traditionally relied on staging as defined by the Union for International Cancer Control (UICC) and American Joint Committee on Cancer (AJCC) TNM staging classifications. However, clinically, there appears to be differences in survival patterns independent of stage, suggesting a complex interaction of stage, pathological features, and biomarkers playing a role in guiding prognosis, risk stratification, and guiding neoadjuvant and adjuvant therapies. Histological features such as tumour budding, perineural invasion, apical lymph node involvement, lymph node yield, lymph node ratio, and molecular features such as MSI, KRAS, BRAF, and CDX2 may assist in prognostication and optimising adjuvant treatment. This study provides a comprehensive review of the pathological features and biomarkers that are important in the prognostication and treatment of CRC. We review the importance of pathological features and biomarkers that may be important in colorectal cancer based on the current evidence in the literature. |
| first_indexed | 2024-03-10T04:19:37Z |
| format | Article |
| id | doaj.art-175cebe138464fd98f2e94a59d833c64 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-10T04:19:37Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-175cebe138464fd98f2e94a59d833c642023-11-23T07:51:14ZengMDPI AGCurrent Oncology1198-00521718-77292021-12-012865356538310.3390/curroncol28060447Pathological Features and Prognostication in Colorectal CancerKabytto Chen0Geoffrey Collins1Henry Wang2James Wei Tatt Toh3Discipline of Surgery, Faculty of Medicine and Health, The University of Sydney, Westmead 2145, AustraliaDiscipline of Surgery, Faculty of Medicine and Health, The University of Sydney, Westmead 2145, AustraliaDiscipline of Surgery, Faculty of Medicine and Health, The University of Sydney, Westmead 2145, AustraliaDiscipline of Surgery, Faculty of Medicine and Health, The University of Sydney, Westmead 2145, AustraliaThe prognostication of colorectal cancer (CRC) has traditionally relied on staging as defined by the Union for International Cancer Control (UICC) and American Joint Committee on Cancer (AJCC) TNM staging classifications. However, clinically, there appears to be differences in survival patterns independent of stage, suggesting a complex interaction of stage, pathological features, and biomarkers playing a role in guiding prognosis, risk stratification, and guiding neoadjuvant and adjuvant therapies. Histological features such as tumour budding, perineural invasion, apical lymph node involvement, lymph node yield, lymph node ratio, and molecular features such as MSI, KRAS, BRAF, and CDX2 may assist in prognostication and optimising adjuvant treatment. This study provides a comprehensive review of the pathological features and biomarkers that are important in the prognostication and treatment of CRC. We review the importance of pathological features and biomarkers that may be important in colorectal cancer based on the current evidence in the literature.https://www.mdpi.com/1718-7729/28/6/447pathological featuresmolecular markerscolorectal cancerprognosissurvival |
| spellingShingle | Kabytto Chen Geoffrey Collins Henry Wang James Wei Tatt Toh Pathological Features and Prognostication in Colorectal Cancer Current Oncology pathological features molecular markers colorectal cancer prognosis survival |
| title | Pathological Features and Prognostication in Colorectal Cancer |
| title_full | Pathological Features and Prognostication in Colorectal Cancer |
| title_fullStr | Pathological Features and Prognostication in Colorectal Cancer |
| title_full_unstemmed | Pathological Features and Prognostication in Colorectal Cancer |
| title_short | Pathological Features and Prognostication in Colorectal Cancer |
| title_sort | pathological features and prognostication in colorectal cancer |
| topic | pathological features molecular markers colorectal cancer prognosis survival |
| url | https://www.mdpi.com/1718-7729/28/6/447 |
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