Fast strain mapping in abdominal aortic aneurysm wall reveals heterogeneous patterns
Abdominal aortic aneurysm patients are regularly monitored to assess aneurysm development and risk of rupture. A preventive surgical procedure is recommended when the maximum aortic antero-posterior diameter, periodically assessed on two-dimensional abdominal ultrasound scans, reaches 5.5 mm. Althou...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1163204/full |
| _version_ | 1797808930848505856 |
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| author | Marta Irene Bracco Marta Irene Bracco Magdalena Broda Ulver Spangsberg Lorenzen Mateusz Cezary Florkow Oudom Somphone Stephane Avril Marco Evangelos Biancolini Laurence Rouet |
| author_facet | Marta Irene Bracco Marta Irene Bracco Magdalena Broda Ulver Spangsberg Lorenzen Mateusz Cezary Florkow Oudom Somphone Stephane Avril Marco Evangelos Biancolini Laurence Rouet |
| author_sort | Marta Irene Bracco |
| collection | DOAJ |
| description | Abdominal aortic aneurysm patients are regularly monitored to assess aneurysm development and risk of rupture. A preventive surgical procedure is recommended when the maximum aortic antero-posterior diameter, periodically assessed on two-dimensional abdominal ultrasound scans, reaches 5.5 mm. Although the maximum diameter criterion has limited ability to predict aneurysm rupture, no clinically relevant tool that could complement the current guidelines has emerged so far. In vivo cyclic strains in the aneurysm wall are related to the wall response to blood pressure pulse, and therefore, they can be linked to wall mechanical properties, which in turn contribute to determining the risk of rupture. This work aimed to enable biomechanical estimations in the aneurysm wall by providing a fast and semi-automatic method to post-process dynamic clinical ultrasound sequences and by mapping the cross-sectional strains on the B-mode image. Specifically, the Sparse Demons algorithm was employed to track the wall motion throughout multiple cardiac cycles. Then, the cyclic strains were mapped by means of radial basis function interpolation and differentiation. We applied our method to two-dimensional sequences from eight patients. The automatic part of the analysis took under 1.5 min per cardiac cycle. The tracking method was validated against simulated ultrasound sequences, and a maximum root mean square error of 0.22 mm was found. The strain was calculated both with our method and with the established finite-element method, and a very good agreement was found, with mean differences of one order of magnitude smaller than the image spatial resolution. Most patients exhibited a strain pattern that suggests interaction with the spine. To conclude, our method is a promising tool for investigating abdominal aortic aneurysm wall biomechanics as it can provide a fast and accurate measurement of the cyclic wall strains from clinical ultrasound sequences. |
| first_indexed | 2024-03-13T06:45:42Z |
| format | Article |
| id | doaj.art-175fe307eb484206ab1ed85cc054a4b0 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-13T06:45:42Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-175fe307eb484206ab1ed85cc054a4b02023-06-08T06:08:34ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-06-011410.3389/fphys.2023.11632041163204Fast strain mapping in abdominal aortic aneurysm wall reveals heterogeneous patternsMarta Irene Bracco0Marta Irene Bracco1Magdalena Broda2Ulver Spangsberg Lorenzen3Mateusz Cezary Florkow4Oudom Somphone5Stephane Avril6Marco Evangelos Biancolini7Laurence Rouet8Mines Saint-Étienne, University Jean Monnet, INSERM, Sainbiose, Saint-Étienne, FrancePhilips Research Paris, Suresnes, FranceDepartment of Vascular Surgery, Rigshospitalet, Copenhagen, DenmarkDepartment of Vascular Surgery, Rigshospitalet, Copenhagen, DenmarkPhilips Research Paris, Suresnes, FrancePhilips Research Paris, Suresnes, FranceMines Saint-Étienne, University Jean Monnet, INSERM, Sainbiose, Saint-Étienne, FranceDepartment of Enterprise Engineering “Mario Lucertini”, University of Rome “Tor Vergata”, Rome, ItalyPhilips Research Paris, Suresnes, FranceAbdominal aortic aneurysm patients are regularly monitored to assess aneurysm development and risk of rupture. A preventive surgical procedure is recommended when the maximum aortic antero-posterior diameter, periodically assessed on two-dimensional abdominal ultrasound scans, reaches 5.5 mm. Although the maximum diameter criterion has limited ability to predict aneurysm rupture, no clinically relevant tool that could complement the current guidelines has emerged so far. In vivo cyclic strains in the aneurysm wall are related to the wall response to blood pressure pulse, and therefore, they can be linked to wall mechanical properties, which in turn contribute to determining the risk of rupture. This work aimed to enable biomechanical estimations in the aneurysm wall by providing a fast and semi-automatic method to post-process dynamic clinical ultrasound sequences and by mapping the cross-sectional strains on the B-mode image. Specifically, the Sparse Demons algorithm was employed to track the wall motion throughout multiple cardiac cycles. Then, the cyclic strains were mapped by means of radial basis function interpolation and differentiation. We applied our method to two-dimensional sequences from eight patients. The automatic part of the analysis took under 1.5 min per cardiac cycle. The tracking method was validated against simulated ultrasound sequences, and a maximum root mean square error of 0.22 mm was found. The strain was calculated both with our method and with the established finite-element method, and a very good agreement was found, with mean differences of one order of magnitude smaller than the image spatial resolution. Most patients exhibited a strain pattern that suggests interaction with the spine. To conclude, our method is a promising tool for investigating abdominal aortic aneurysm wall biomechanics as it can provide a fast and accurate measurement of the cyclic wall strains from clinical ultrasound sequences.https://www.frontiersin.org/articles/10.3389/fphys.2023.1163204/fullabdominal aortic aneurysmultrasound B-mode cine-loopsvascular wall strainsstrain imagingultrasound elastographyultrasound simulations |
| spellingShingle | Marta Irene Bracco Marta Irene Bracco Magdalena Broda Ulver Spangsberg Lorenzen Mateusz Cezary Florkow Oudom Somphone Stephane Avril Marco Evangelos Biancolini Laurence Rouet Fast strain mapping in abdominal aortic aneurysm wall reveals heterogeneous patterns Frontiers in Physiology abdominal aortic aneurysm ultrasound B-mode cine-loops vascular wall strains strain imaging ultrasound elastography ultrasound simulations |
| title | Fast strain mapping in abdominal aortic aneurysm wall reveals heterogeneous patterns |
| title_full | Fast strain mapping in abdominal aortic aneurysm wall reveals heterogeneous patterns |
| title_fullStr | Fast strain mapping in abdominal aortic aneurysm wall reveals heterogeneous patterns |
| title_full_unstemmed | Fast strain mapping in abdominal aortic aneurysm wall reveals heterogeneous patterns |
| title_short | Fast strain mapping in abdominal aortic aneurysm wall reveals heterogeneous patterns |
| title_sort | fast strain mapping in abdominal aortic aneurysm wall reveals heterogeneous patterns |
| topic | abdominal aortic aneurysm ultrasound B-mode cine-loops vascular wall strains strain imaging ultrasound elastography ultrasound simulations |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1163204/full |
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