S. pombe placed on the prion map
Schizosaccharomyces pombe has been used extensively as a model organism, however it is only recently that the first prion in this organism, a copper transporter protein encoded by ctr4, has been conclusively demonstrated. Prions are found in a wide range of organisms and have been implicated in a nu...
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2017-02-01
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| Series: | Microbial Cell |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/s-pombe-placed-on-the-prion-map/ |
| _version_ | 1826532081787731968 |
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| author | Jacqueline Hayles |
| author_facet | Jacqueline Hayles |
| author_sort | Jacqueline Hayles |
| collection | DOAJ |
| description | Schizosaccharomyces pombe has been used extensively as a model organism, however it is only recently that the first prion in this organism, a copper transporter protein encoded by ctr4, has been conclusively demonstrated. Prions are found in a wide range of organisms and have been implicated in a number of human neurodegenerative diseases. Research into the biology of prions has been carried out mainly in the budding yeast Saccharomyces cerevisiae, however there are many questions still to be addressed. Now, with the identification of the Ctr4 prion in S. pombe, further work in the two yeasts and comparisons of prion biology in these organisms should lead to a greater understanding of prions and their role in disease. |
| first_indexed | 2024-12-14T04:08:40Z |
| format | Article |
| id | doaj.art-176014a335f14f55b1addb296db149c1 |
| institution | Directory Open Access Journal |
| issn | 2311-2638 |
| language | English |
| last_indexed | 2025-03-14T01:45:34Z |
| publishDate | 2017-02-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj.art-176014a335f14f55b1addb296db149c12025-03-12T13:46:40ZengShared Science Publishers OGMicrobial Cell2311-26382017-02-0142353710.15698/mic2017.02.555S. pombe placed on the prion mapJacqueline Hayles0Cell Cycle Laboratory, The Francis Crick Institute, I, Midland Road, London NW1 1AT, United Kingdom.Schizosaccharomyces pombe has been used extensively as a model organism, however it is only recently that the first prion in this organism, a copper transporter protein encoded by ctr4, has been conclusively demonstrated. Prions are found in a wide range of organisms and have been implicated in a number of human neurodegenerative diseases. Research into the biology of prions has been carried out mainly in the budding yeast Saccharomyces cerevisiae, however there are many questions still to be addressed. Now, with the identification of the Ctr4 prion in S. pombe, further work in the two yeasts and comparisons of prion biology in these organisms should lead to a greater understanding of prions and their role in disease.http://microbialcell.com/researcharticles/s-pombe-placed-on-the-prion-map/ S. pombeCtr4prionHsp104fission yeast |
| spellingShingle | Jacqueline Hayles S. pombe placed on the prion map Microbial Cell S. pombe Ctr4 prion Hsp104 fission yeast |
| title | S. pombe placed on the prion map |
| title_full | S. pombe placed on the prion map |
| title_fullStr | S. pombe placed on the prion map |
| title_full_unstemmed | S. pombe placed on the prion map |
| title_short | S. pombe placed on the prion map |
| title_sort | s pombe placed on the prion map |
| topic | S. pombe Ctr4 prion Hsp104 fission yeast |
| url | http://microbialcell.com/researcharticles/s-pombe-placed-on-the-prion-map/ |
| work_keys_str_mv | AT jacquelinehayles spombeplacedontheprionmap |