Early Markers of Cardiovascular Disease Associated with Clinical Data and Autosomal Ancestry in Patients with Type 1 Diabetes: A Cross-Sectional Study in an Admixed Brazilian Population
Patients with type 1 diabetes (T1D) have a higher risk of developing cardiovascular disease (CVD), which is a major cause of death in this population. This study investigates early markers of CVD associated with clinical data and autosomal ancestry in T1D patients from an admixed Brazilian populatio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/2/389 |
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| author | Roberta Maria Duailibe Ferreira Reis Rossana Santiago de Sousa Azulay Maria da Glória Tavares Gilvan Cortês Nascimento Sabrina da Silva Pereira Damianse Viviane Chaves de Carvalho Rocha Ana Gregória Almeida Débora Cristina Ferreira Lago Vandilson Rodrigues Marcelo Magalhães Carla Souza Sobral Conceição Parente Joana França Jacqueline Ribeiro Paulo Cézar Dias Ferraz Carlos Alberto Azulay Junior Dayse Aparecida Silva Marília Brito Gomes Manuel dos Santos Faria |
| author_facet | Roberta Maria Duailibe Ferreira Reis Rossana Santiago de Sousa Azulay Maria da Glória Tavares Gilvan Cortês Nascimento Sabrina da Silva Pereira Damianse Viviane Chaves de Carvalho Rocha Ana Gregória Almeida Débora Cristina Ferreira Lago Vandilson Rodrigues Marcelo Magalhães Carla Souza Sobral Conceição Parente Joana França Jacqueline Ribeiro Paulo Cézar Dias Ferraz Carlos Alberto Azulay Junior Dayse Aparecida Silva Marília Brito Gomes Manuel dos Santos Faria |
| author_sort | Roberta Maria Duailibe Ferreira Reis |
| collection | DOAJ |
| description | Patients with type 1 diabetes (T1D) have a higher risk of developing cardiovascular disease (CVD), which is a major cause of death in this population. This study investigates early markers of CVD associated with clinical data and autosomal ancestry in T1D patients from an admixed Brazilian population. A cross-sectional study was conducted with 99 T1D patients. The mean age of the study sample was 27.6 years and the mean duration of T1D was 14.4 years. The frequencies of abnormalities of the early markers of CVD were 19.6% in the ankle-brachial index (ABI), 4.1% in the coronary artery calcium score (CACS), and 5% in the carotid Doppler. A significant percentage of agreement was observed for the comparison of the frequency of abnormalities between CACS and carotid Doppler (92.2%, <i>p</i> = 0.041). There was no significant association between the level of autosomal ancestry proportions and early markers of CVD. The ABI was useful in the early identification of CVD in asymptomatic young patients with T1D and with a short duration of disease. Although CACS and carotid Doppler are non-invasive tests, carotid Doppler is more cost-effective, and both have limitations in screening for CVD in young patients with a short duration of T1D. We did not find a statistically significant relationship between autosomal ancestry proportions and early CVD markers in an admixed Brazilian population. |
| first_indexed | 2024-03-09T21:51:31Z |
| format | Article |
| id | doaj.art-176097f13f494f6292d40216af40ed80 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T21:51:31Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-176097f13f494f6292d40216af40ed802023-11-23T20:06:07ZengMDPI AGGenes2073-44252022-02-0113238910.3390/genes13020389Early Markers of Cardiovascular Disease Associated with Clinical Data and Autosomal Ancestry in Patients with Type 1 Diabetes: A Cross-Sectional Study in an Admixed Brazilian PopulationRoberta Maria Duailibe Ferreira Reis0Rossana Santiago de Sousa Azulay1Maria da Glória Tavares2Gilvan Cortês Nascimento3Sabrina da Silva Pereira Damianse4Viviane Chaves de Carvalho Rocha5Ana Gregória Almeida6Débora Cristina Ferreira Lago7Vandilson Rodrigues8Marcelo Magalhães9Carla Souza Sobral10Conceição Parente11Joana França12Jacqueline Ribeiro13Paulo Cézar Dias Ferraz14Carlos Alberto Azulay Junior15Dayse Aparecida Silva16Marília Brito Gomes17Manuel dos Santos Faria18Graduate Program in Adult Health (PPGSAD), Federal University of Maranhão-UFMA, Av. dos Portugueses, São Luís 65085-580, BrazilService of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA/EBSERH), Rua Barão de Itapary, 227-Centro, São Luís 65020-070, BrazilService of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA/EBSERH), Rua Barão de Itapary, 227-Centro, São Luís 65020-070, BrazilService of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA/EBSERH), Rua Barão de Itapary, 227-Centro, São Luís 65020-070, BrazilService of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA/EBSERH), Rua Barão de Itapary, 227-Centro, São Luís 65020-070, BrazilService of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA/EBSERH), Rua Barão de Itapary, 227-Centro, São Luís 65020-070, BrazilResearch Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), São Luís 65020-070, BrazilService of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA/EBSERH), Rua Barão de Itapary, 227-Centro, São Luís 65020-070, BrazilResearch Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), São Luís 65020-070, BrazilGraduate Program in Adult Health (PPGSAD), Federal University of Maranhão-UFMA, Av. dos Portugueses, São Luís 65085-580, BrazilService of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA/EBSERH), Rua Barão de Itapary, 227-Centro, São Luís 65020-070, BrazilService of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA/EBSERH), Rua Barão de Itapary, 227-Centro, São Luís 65020-070, BrazilService of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA/EBSERH), Rua Barão de Itapary, 227-Centro, São Luís 65020-070, BrazilResearch Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), São Luís 65020-070, BrazilResearch Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), São Luís 65020-070, BrazilResearch Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), São Luís 65020-070, BrazilDNA Diagnostic Laboratory (LDD), Rio de Janeiro State University (UERJ), R. São Francisco Xavier, Rio de Janeiro 20550-013, BrazilDiabetes Unit, State University of Rio de Janeiro (UERJ), R. São Francisco Xavier, Rio de Janeiro 20550-013, BrazilGraduate Program in Adult Health (PPGSAD), Federal University of Maranhão-UFMA, Av. dos Portugueses, São Luís 65085-580, BrazilPatients with type 1 diabetes (T1D) have a higher risk of developing cardiovascular disease (CVD), which is a major cause of death in this population. This study investigates early markers of CVD associated with clinical data and autosomal ancestry in T1D patients from an admixed Brazilian population. A cross-sectional study was conducted with 99 T1D patients. The mean age of the study sample was 27.6 years and the mean duration of T1D was 14.4 years. The frequencies of abnormalities of the early markers of CVD were 19.6% in the ankle-brachial index (ABI), 4.1% in the coronary artery calcium score (CACS), and 5% in the carotid Doppler. A significant percentage of agreement was observed for the comparison of the frequency of abnormalities between CACS and carotid Doppler (92.2%, <i>p</i> = 0.041). There was no significant association between the level of autosomal ancestry proportions and early markers of CVD. The ABI was useful in the early identification of CVD in asymptomatic young patients with T1D and with a short duration of disease. Although CACS and carotid Doppler are non-invasive tests, carotid Doppler is more cost-effective, and both have limitations in screening for CVD in young patients with a short duration of T1D. We did not find a statistically significant relationship between autosomal ancestry proportions and early CVD markers in an admixed Brazilian population.https://www.mdpi.com/2073-4425/13/2/389type 1 diabetescardiovascular diseasecalcium scorecarotid Dopplerankle-brachial indexancestry |
| spellingShingle | Roberta Maria Duailibe Ferreira Reis Rossana Santiago de Sousa Azulay Maria da Glória Tavares Gilvan Cortês Nascimento Sabrina da Silva Pereira Damianse Viviane Chaves de Carvalho Rocha Ana Gregória Almeida Débora Cristina Ferreira Lago Vandilson Rodrigues Marcelo Magalhães Carla Souza Sobral Conceição Parente Joana França Jacqueline Ribeiro Paulo Cézar Dias Ferraz Carlos Alberto Azulay Junior Dayse Aparecida Silva Marília Brito Gomes Manuel dos Santos Faria Early Markers of Cardiovascular Disease Associated with Clinical Data and Autosomal Ancestry in Patients with Type 1 Diabetes: A Cross-Sectional Study in an Admixed Brazilian Population Genes type 1 diabetes cardiovascular disease calcium score carotid Doppler ankle-brachial index ancestry |
| title | Early Markers of Cardiovascular Disease Associated with Clinical Data and Autosomal Ancestry in Patients with Type 1 Diabetes: A Cross-Sectional Study in an Admixed Brazilian Population |
| title_full | Early Markers of Cardiovascular Disease Associated with Clinical Data and Autosomal Ancestry in Patients with Type 1 Diabetes: A Cross-Sectional Study in an Admixed Brazilian Population |
| title_fullStr | Early Markers of Cardiovascular Disease Associated with Clinical Data and Autosomal Ancestry in Patients with Type 1 Diabetes: A Cross-Sectional Study in an Admixed Brazilian Population |
| title_full_unstemmed | Early Markers of Cardiovascular Disease Associated with Clinical Data and Autosomal Ancestry in Patients with Type 1 Diabetes: A Cross-Sectional Study in an Admixed Brazilian Population |
| title_short | Early Markers of Cardiovascular Disease Associated with Clinical Data and Autosomal Ancestry in Patients with Type 1 Diabetes: A Cross-Sectional Study in an Admixed Brazilian Population |
| title_sort | early markers of cardiovascular disease associated with clinical data and autosomal ancestry in patients with type 1 diabetes a cross sectional study in an admixed brazilian population |
| topic | type 1 diabetes cardiovascular disease calcium score carotid Doppler ankle-brachial index ancestry |
| url | https://www.mdpi.com/2073-4425/13/2/389 |
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