Comparing lesion detection efficacy and image quality across different PET system generations to optimize the iodine-124 PET protocol for recurrent thyroid cancer
Abstract Background In recurrent differentiated thyroid cancer patients, detectability in 124I PET is limited for lesions with low radioiodine uptake. We assess the improvements in lesion detectability and image quality between three generations of PET scanners with different detector technologies....
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2021-02-01
|
| Series: | EJNMMI Physics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40658-021-00361-y |
| _version_ | 1819170538287792128 |
|---|---|
| author | David Kersting Walter Jentzen Miriam Sraieb Pedro Fragoso Costa Maurizio Conti Lale Umutlu Gerald Antoch Michael Nader Ken Herrmann Wolfgang Peter Fendler Christoph Rischpler Manuel Weber |
| author_facet | David Kersting Walter Jentzen Miriam Sraieb Pedro Fragoso Costa Maurizio Conti Lale Umutlu Gerald Antoch Michael Nader Ken Herrmann Wolfgang Peter Fendler Christoph Rischpler Manuel Weber |
| author_sort | David Kersting |
| collection | DOAJ |
| description | Abstract Background In recurrent differentiated thyroid cancer patients, detectability in 124I PET is limited for lesions with low radioiodine uptake. We assess the improvements in lesion detectability and image quality between three generations of PET scanners with different detector technologies. The results are used to suggest an optimized protocol. Methods Datasets of 10 patients with low increasing thyroglobulin or thyroglobulin antibody levels after total thyroidectomy and radioiodine therapies were included. PET data were acquired and reconstructed on a Biograph mCT PET/CT (whole-body, 4-min acquisition time per bed position; OSEM, OSEM-TOF, OSEM-TOF+PSF), a non-TOF Biograph mMR PET/MR (neck region, 4 min and 20 min; OSEM), and a new generation Biograph Vision PET/CT (whole-body, 4 min; OSEM, OSEM-TOF, OSEM-TOF+PSF). The 20-min image on the mMR was used as reference to calculate the detection efficacy in the neck region. Image quality was rated on a 5-point scale. Results All detected lesions were in the neck region. Detection efficacy was 8/9 (Vision OSEM-TOF and OSEM-TOF+PSF), 4/9 (Vision OSEM), 3/9 (mMR OSEM and mCT OSEM-TOF+PSF), and 2/9 (mCT OSEM and OSEM-TOF). Median image quality was 4 (Vision OSEM-TOF and OSEM-TOF+PSF), 3 (Vision OSEM, mCT OSEM-TOF+PSF, and mMR OSEM 20-min), 2 (mCT OSEM-TOF), 1.5 (mCT OSEM), and 1 (mMR OSEM 4 min). Conclusion At a clinical standard acquisition time of 4 min per bed position, the new generation Biograph Vision using a TOF-based image reconstruction demonstrated the highest detectability and image quality and should, if available, be preferably used for imaging of low-uptake lesions. A prolonged acquisition time for the mostly affected neck region can be useful. |
| first_indexed | 2024-12-22T19:36:59Z |
| format | Article |
| id | doaj.art-176100a1696d470c92044b28e3f2a1e9 |
| institution | Directory Open Access Journal |
| issn | 2197-7364 |
| language | English |
| last_indexed | 2024-12-22T19:36:59Z |
| publishDate | 2021-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Physics |
| spelling | doaj.art-176100a1696d470c92044b28e3f2a1e92022-12-21T18:14:57ZengSpringerOpenEJNMMI Physics2197-73642021-02-018111410.1186/s40658-021-00361-yComparing lesion detection efficacy and image quality across different PET system generations to optimize the iodine-124 PET protocol for recurrent thyroid cancerDavid Kersting0Walter Jentzen1Miriam Sraieb2Pedro Fragoso Costa3Maurizio Conti4Lale Umutlu5Gerald Antoch6Michael Nader7Ken Herrmann8Wolfgang Peter Fendler9Christoph Rischpler10Manuel Weber11Department of Nuclear Medicine, University Hospital Essen, University of Duisburg-EssenDepartment of Nuclear Medicine, University Hospital Essen, University of Duisburg-EssenDepartment of Nuclear Medicine, University Hospital Essen, University of Duisburg-EssenDepartment of Nuclear Medicine, University Hospital Essen, University of Duisburg-EssenSiemens Medical Solutions USA, Inc.West German Cancer Center (WTZ)German Cancer Consortium (DKTK)Department of Nuclear Medicine, University Hospital Essen, University of Duisburg-EssenDepartment of Nuclear Medicine, University Hospital Essen, University of Duisburg-EssenDepartment of Nuclear Medicine, University Hospital Essen, University of Duisburg-EssenDepartment of Nuclear Medicine, University Hospital Essen, University of Duisburg-EssenDepartment of Nuclear Medicine, University Hospital Essen, University of Duisburg-EssenAbstract Background In recurrent differentiated thyroid cancer patients, detectability in 124I PET is limited for lesions with low radioiodine uptake. We assess the improvements in lesion detectability and image quality between three generations of PET scanners with different detector technologies. The results are used to suggest an optimized protocol. Methods Datasets of 10 patients with low increasing thyroglobulin or thyroglobulin antibody levels after total thyroidectomy and radioiodine therapies were included. PET data were acquired and reconstructed on a Biograph mCT PET/CT (whole-body, 4-min acquisition time per bed position; OSEM, OSEM-TOF, OSEM-TOF+PSF), a non-TOF Biograph mMR PET/MR (neck region, 4 min and 20 min; OSEM), and a new generation Biograph Vision PET/CT (whole-body, 4 min; OSEM, OSEM-TOF, OSEM-TOF+PSF). The 20-min image on the mMR was used as reference to calculate the detection efficacy in the neck region. Image quality was rated on a 5-point scale. Results All detected lesions were in the neck region. Detection efficacy was 8/9 (Vision OSEM-TOF and OSEM-TOF+PSF), 4/9 (Vision OSEM), 3/9 (mMR OSEM and mCT OSEM-TOF+PSF), and 2/9 (mCT OSEM and OSEM-TOF). Median image quality was 4 (Vision OSEM-TOF and OSEM-TOF+PSF), 3 (Vision OSEM, mCT OSEM-TOF+PSF, and mMR OSEM 20-min), 2 (mCT OSEM-TOF), 1.5 (mCT OSEM), and 1 (mMR OSEM 4 min). Conclusion At a clinical standard acquisition time of 4 min per bed position, the new generation Biograph Vision using a TOF-based image reconstruction demonstrated the highest detectability and image quality and should, if available, be preferably used for imaging of low-uptake lesions. A prolonged acquisition time for the mostly affected neck region can be useful.https://doi.org/10.1186/s40658-021-00361-yIodine-124 PETDigital PET/CTBiograph VisionDetectabilityDifferentiated thyroid cancer |
| spellingShingle | David Kersting Walter Jentzen Miriam Sraieb Pedro Fragoso Costa Maurizio Conti Lale Umutlu Gerald Antoch Michael Nader Ken Herrmann Wolfgang Peter Fendler Christoph Rischpler Manuel Weber Comparing lesion detection efficacy and image quality across different PET system generations to optimize the iodine-124 PET protocol for recurrent thyroid cancer EJNMMI Physics Iodine-124 PET Digital PET/CT Biograph Vision Detectability Differentiated thyroid cancer |
| title | Comparing lesion detection efficacy and image quality across different PET system generations to optimize the iodine-124 PET protocol for recurrent thyroid cancer |
| title_full | Comparing lesion detection efficacy and image quality across different PET system generations to optimize the iodine-124 PET protocol for recurrent thyroid cancer |
| title_fullStr | Comparing lesion detection efficacy and image quality across different PET system generations to optimize the iodine-124 PET protocol for recurrent thyroid cancer |
| title_full_unstemmed | Comparing lesion detection efficacy and image quality across different PET system generations to optimize the iodine-124 PET protocol for recurrent thyroid cancer |
| title_short | Comparing lesion detection efficacy and image quality across different PET system generations to optimize the iodine-124 PET protocol for recurrent thyroid cancer |
| title_sort | comparing lesion detection efficacy and image quality across different pet system generations to optimize the iodine 124 pet protocol for recurrent thyroid cancer |
| topic | Iodine-124 PET Digital PET/CT Biograph Vision Detectability Differentiated thyroid cancer |
| url | https://doi.org/10.1186/s40658-021-00361-y |
| work_keys_str_mv | AT davidkersting comparinglesiondetectionefficacyandimagequalityacrossdifferentpetsystemgenerationstooptimizetheiodine124petprotocolforrecurrentthyroidcancer AT walterjentzen comparinglesiondetectionefficacyandimagequalityacrossdifferentpetsystemgenerationstooptimizetheiodine124petprotocolforrecurrentthyroidcancer AT miriamsraieb comparinglesiondetectionefficacyandimagequalityacrossdifferentpetsystemgenerationstooptimizetheiodine124petprotocolforrecurrentthyroidcancer AT pedrofragosocosta comparinglesiondetectionefficacyandimagequalityacrossdifferentpetsystemgenerationstooptimizetheiodine124petprotocolforrecurrentthyroidcancer AT maurizioconti comparinglesiondetectionefficacyandimagequalityacrossdifferentpetsystemgenerationstooptimizetheiodine124petprotocolforrecurrentthyroidcancer AT laleumutlu comparinglesiondetectionefficacyandimagequalityacrossdifferentpetsystemgenerationstooptimizetheiodine124petprotocolforrecurrentthyroidcancer AT geraldantoch comparinglesiondetectionefficacyandimagequalityacrossdifferentpetsystemgenerationstooptimizetheiodine124petprotocolforrecurrentthyroidcancer AT michaelnader comparinglesiondetectionefficacyandimagequalityacrossdifferentpetsystemgenerationstooptimizetheiodine124petprotocolforrecurrentthyroidcancer AT kenherrmann comparinglesiondetectionefficacyandimagequalityacrossdifferentpetsystemgenerationstooptimizetheiodine124petprotocolforrecurrentthyroidcancer AT wolfgangpeterfendler comparinglesiondetectionefficacyandimagequalityacrossdifferentpetsystemgenerationstooptimizetheiodine124petprotocolforrecurrentthyroidcancer AT christophrischpler comparinglesiondetectionefficacyandimagequalityacrossdifferentpetsystemgenerationstooptimizetheiodine124petprotocolforrecurrentthyroidcancer AT manuelweber comparinglesiondetectionefficacyandimagequalityacrossdifferentpetsystemgenerationstooptimizetheiodine124petprotocolforrecurrentthyroidcancer |