GM-CSF Nitration Is a New Driver of Myeloid Suppressor Cell Activity in Tumors

GM-CSF Nitration Is a New Driver of Myeloid Suppressor Cell Activity in Tumors

Reactive oxygen species, including RNS, contribute to the control of multiple immune cell functions within the tumor microenvironment (TME). Tumor-infiltrating myeloid cells (TIMs) represent the archetype of tolerogenic cells that actively contribute to dismantle effective immunity against cancer. T...

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Bibliographic Details
Main Authors: Bianca Calì, Andrielly H. R. Agnellini, Chiara Cioccarelli, Ricardo Sanchez-Rodriguez, Andrea Predonzani, Giulia Ilaria Toffolo, Antonella Viola, Vincenzo Bronte, Giorgio Arrigoni, Francesco Zonta, Laura Albertoni, Claudia Mescoli, Ilaria Marigo, Barbara Molon
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
reactive nitrogen species
cytokines
immunosuppression
post-translational modification
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.718098/full

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