TRACking health behaviors in people with Multiple Sclerosis (TRAC-MS): Study protocol and description of the study sample
Introduction: People with multiple sclerosis (PwMS) experience a range of physical, cognitive, and affective symptoms. Behavioral interventions targeting increased physical activity show promising support as low-cost methods to improve working memory, episodic memory, and processing speed in PwMS. I...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Contemporary Clinical Trials Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451865422001235 |
| _version_ | 1811178223361327104 |
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| author | Ruchika S. Prakash Heena R. Manglani Elizabeth J. Duraney Anita Shankar Megan E. Fisher Alisha Janssen Lauren Cea Rick Petosa Rebecca Andridge Jacqueline Nicholas |
| author_facet | Ruchika S. Prakash Heena R. Manglani Elizabeth J. Duraney Anita Shankar Megan E. Fisher Alisha Janssen Lauren Cea Rick Petosa Rebecca Andridge Jacqueline Nicholas |
| author_sort | Ruchika S. Prakash |
| collection | DOAJ |
| description | Introduction: People with multiple sclerosis (PwMS) experience a range of physical, cognitive, and affective symptoms. Behavioral interventions targeting increased physical activity show promising support as low-cost methods to improve working memory, episodic memory, and processing speed in PwMS. In this randomized controlled trial, we will examine the efficacy of a pedometer-tracking intervention, designed to increase low-to-moderate levels of physical activity, for improving working memory in PwMS. Methods and Analysis: Eighty-seven PwMS, between the ages of 30–59, have been recruited for the study. Seventy-five of the eligible and interested individuals were randomized to six-month health behavior monitoring groups: a Step-track group or a Water-track group (serving as the active control). Neuropsychological measures, assessing the primary outcome of the study, were administered at pre, midpoint, and post-intervention. Exploratory factor analysis of neuropsychological measures resulted in three factors: a working memory/processing speed factor, a visual episodic memory factor, and a verbal episodic memory factor. Changes in this latent measure of working memory/processing speed is the primary outcome of the current study. Functional MRI data will be analyzed to examine changes in the functional connectivity of the neural network supporting working memory. Ethics and dissemination: The institutional review board granted approval for the study and all participants provided written informed consent. The results of this study will provide support showing that step-tracking increases overall levels of physical activity, improves working memory and processing speed, and strengthens the neural circuitry that supports better cognition. Evidence from this study will thus offer promising support for the routine use of step-tracking devices to improve cognitive functioning in PwMS. Study results will be disseminated through peer-reviewed publications and presentations at scientific conferences. |
| first_indexed | 2024-04-11T06:16:01Z |
| format | Article |
| id | doaj.art-1765f1a7eda543d7a9b022d25e9861b5 |
| institution | Directory Open Access Journal |
| issn | 2451-8654 |
| language | English |
| last_indexed | 2024-04-11T06:16:01Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Contemporary Clinical Trials Communications |
| spelling | doaj.art-1765f1a7eda543d7a9b022d25e9861b52022-12-22T04:41:03ZengElsevierContemporary Clinical Trials Communications2451-86542022-12-0130101006TRACking health behaviors in people with Multiple Sclerosis (TRAC-MS): Study protocol and description of the study sampleRuchika S. Prakash0Heena R. Manglani1Elizabeth J. Duraney2Anita Shankar3Megan E. Fisher4Alisha Janssen5Lauren Cea6Rick Petosa7Rebecca Andridge8Jacqueline Nicholas9Department of Psychology, The Ohio State University, Columbus, OH, USA; Center for Cognitive and Behavioral Brain Imaging, The Ohio State University Columbus, OH, USA; Corresponding author. Department of Psychology, The Ohio State University, 139 Psychology Building 1835 Neil Avenue, Columbus, OH 43210, USA.Department of Psychology, The Ohio State University, Columbus, OH, USADepartment of Psychology, The Ohio State University, Columbus, OH, USADepartment of Psychology, The Ohio State University, Columbus, OH, USADepartment of Psychology, The Ohio State University, Columbus, OH, USADepartment of Psychology, The Ohio State University, Columbus, OH, USADepartment of Psychology, The Ohio State University, Columbus, OH, USADepartment of Human Sciences, The Ohio State University, Columbus, OH, USADepartment of Biostatistics, The Ohio State University, Columbus, OH, USAOhio Health Multiple Sclerosis Center, Columbus, OH, USAIntroduction: People with multiple sclerosis (PwMS) experience a range of physical, cognitive, and affective symptoms. Behavioral interventions targeting increased physical activity show promising support as low-cost methods to improve working memory, episodic memory, and processing speed in PwMS. In this randomized controlled trial, we will examine the efficacy of a pedometer-tracking intervention, designed to increase low-to-moderate levels of physical activity, for improving working memory in PwMS. Methods and Analysis: Eighty-seven PwMS, between the ages of 30–59, have been recruited for the study. Seventy-five of the eligible and interested individuals were randomized to six-month health behavior monitoring groups: a Step-track group or a Water-track group (serving as the active control). Neuropsychological measures, assessing the primary outcome of the study, were administered at pre, midpoint, and post-intervention. Exploratory factor analysis of neuropsychological measures resulted in three factors: a working memory/processing speed factor, a visual episodic memory factor, and a verbal episodic memory factor. Changes in this latent measure of working memory/processing speed is the primary outcome of the current study. Functional MRI data will be analyzed to examine changes in the functional connectivity of the neural network supporting working memory. Ethics and dissemination: The institutional review board granted approval for the study and all participants provided written informed consent. The results of this study will provide support showing that step-tracking increases overall levels of physical activity, improves working memory and processing speed, and strengthens the neural circuitry that supports better cognition. Evidence from this study will thus offer promising support for the routine use of step-tracking devices to improve cognitive functioning in PwMS. Study results will be disseminated through peer-reviewed publications and presentations at scientific conferences.http://www.sciencedirect.com/science/article/pii/S2451865422001235Multiple sclerosisPedometer-trackingRandomized controlled trialPhysical activityCognition |
| spellingShingle | Ruchika S. Prakash Heena R. Manglani Elizabeth J. Duraney Anita Shankar Megan E. Fisher Alisha Janssen Lauren Cea Rick Petosa Rebecca Andridge Jacqueline Nicholas TRACking health behaviors in people with Multiple Sclerosis (TRAC-MS): Study protocol and description of the study sample Contemporary Clinical Trials Communications Multiple sclerosis Pedometer-tracking Randomized controlled trial Physical activity Cognition |
| title | TRACking health behaviors in people with Multiple Sclerosis (TRAC-MS): Study protocol and description of the study sample |
| title_full | TRACking health behaviors in people with Multiple Sclerosis (TRAC-MS): Study protocol and description of the study sample |
| title_fullStr | TRACking health behaviors in people with Multiple Sclerosis (TRAC-MS): Study protocol and description of the study sample |
| title_full_unstemmed | TRACking health behaviors in people with Multiple Sclerosis (TRAC-MS): Study protocol and description of the study sample |
| title_short | TRACking health behaviors in people with Multiple Sclerosis (TRAC-MS): Study protocol and description of the study sample |
| title_sort | tracking health behaviors in people with multiple sclerosis trac ms study protocol and description of the study sample |
| topic | Multiple sclerosis Pedometer-tracking Randomized controlled trial Physical activity Cognition |
| url | http://www.sciencedirect.com/science/article/pii/S2451865422001235 |
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