C reactive protein elevation among children or among mothers’ of children with autism during pregnancy, a review and meta-analysis
Abstract Objective To evaluate if children with ASD, or mothers of ASD children have elevated CRP during pregnancy. Background Autism spectrum disorder (ASD) is a neuro developmental disorder with incidence of 1 in 68 children occur in all racial, ethnic, and socioeconomic groups. Economic burden be...
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12888-020-02619-8 |
| _version_ | 1818280625032921088 |
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| author | Rashid Nadeem Tamseela Hussain Hassan Sajid |
| author_facet | Rashid Nadeem Tamseela Hussain Hassan Sajid |
| author_sort | Rashid Nadeem |
| collection | DOAJ |
| description | Abstract Objective To evaluate if children with ASD, or mothers of ASD children have elevated CRP during pregnancy. Background Autism spectrum disorder (ASD) is a neuro developmental disorder with incidence of 1 in 68 children occur in all racial, ethnic, and socioeconomic groups. Economic burden between $11.5 billion - $60.9 billion and family average medical expenditures of $4110–$6200 per year. Conflicting evidence exist about role of maternal CRP during pregnancy with ASD child. Methods Searches on database; Pubmed, Medline, Embase and google scholar using key words; C reactive protein (CRP), Maternal CRP, ASD, autism, autistic disorder, Inflammation. All English-language studies published between 1960 and 2019 pertaining to CRP and ASD. All Studies which provided data on CRP levels during pregnancy (mCRP) of Mothers of offsprings with ASD and (mCRP) of mothers of normal subjects were selected. Data were extracted in the form of odd ratios of having high mCRP in mothers of children with ASD versus mCRP of mothers of normal controls. Since these odd ratios were adjusted, therefore no Meta regression were attempted. Significant heterogeneity was found; therefore, random effect model was employed. Results Review of CRP levels in children with ASD showed higher level in children with ASD than control, although different methodology and absence of numerical data did not allow metanalysis. Regarding mCRP and ASD, three studies were identified that provide data on mCRP and ASD. Four datasets were created from these 3 studies as the study by Zerbo et al. provided data in 2 subsets. Total number of subjects were 5258 (Brown, N = 677, Zerbo = 416, Koks = 4165) extracted data from these studies was pooled for analysis. Random effect model was employed and substantial heterogeneity among the studies was observed 11. Mothers of children with ASD have adjusted Odd ratio of 1.02 (0.948 to 1.103, I2 = 75, P = 0.558) to have high mCRP comparing mothers of control. Conclusion Mothers of children with ASD appear not to have elevated CRP during pregnancy. Children with ASD appear to have higher levels of CRP levels. |
| first_indexed | 2024-12-12T23:52:12Z |
| format | Article |
| id | doaj.art-17675af3a3db41fea7b28a6e6bc9b851 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-12T23:52:12Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-17675af3a3db41fea7b28a6e6bc9b8512022-12-22T00:06:40ZengBMCBMC Psychiatry1471-244X2020-05-012011710.1186/s12888-020-02619-8C reactive protein elevation among children or among mothers’ of children with autism during pregnancy, a review and meta-analysisRashid Nadeem0Tamseela Hussain1Hassan Sajid2Dubai HospitalRonin InstituteMcMaster UniversityAbstract Objective To evaluate if children with ASD, or mothers of ASD children have elevated CRP during pregnancy. Background Autism spectrum disorder (ASD) is a neuro developmental disorder with incidence of 1 in 68 children occur in all racial, ethnic, and socioeconomic groups. Economic burden between $11.5 billion - $60.9 billion and family average medical expenditures of $4110–$6200 per year. Conflicting evidence exist about role of maternal CRP during pregnancy with ASD child. Methods Searches on database; Pubmed, Medline, Embase and google scholar using key words; C reactive protein (CRP), Maternal CRP, ASD, autism, autistic disorder, Inflammation. All English-language studies published between 1960 and 2019 pertaining to CRP and ASD. All Studies which provided data on CRP levels during pregnancy (mCRP) of Mothers of offsprings with ASD and (mCRP) of mothers of normal subjects were selected. Data were extracted in the form of odd ratios of having high mCRP in mothers of children with ASD versus mCRP of mothers of normal controls. Since these odd ratios were adjusted, therefore no Meta regression were attempted. Significant heterogeneity was found; therefore, random effect model was employed. Results Review of CRP levels in children with ASD showed higher level in children with ASD than control, although different methodology and absence of numerical data did not allow metanalysis. Regarding mCRP and ASD, three studies were identified that provide data on mCRP and ASD. Four datasets were created from these 3 studies as the study by Zerbo et al. provided data in 2 subsets. Total number of subjects were 5258 (Brown, N = 677, Zerbo = 416, Koks = 4165) extracted data from these studies was pooled for analysis. Random effect model was employed and substantial heterogeneity among the studies was observed 11. Mothers of children with ASD have adjusted Odd ratio of 1.02 (0.948 to 1.103, I2 = 75, P = 0.558) to have high mCRP comparing mothers of control. Conclusion Mothers of children with ASD appear not to have elevated CRP during pregnancy. Children with ASD appear to have higher levels of CRP levels.http://link.springer.com/article/10.1186/s12888-020-02619-8ASDAutismAutism spectrum disorderCRPMaternal CRP |
| spellingShingle | Rashid Nadeem Tamseela Hussain Hassan Sajid C reactive protein elevation among children or among mothers’ of children with autism during pregnancy, a review and meta-analysis BMC Psychiatry ASD Autism Autism spectrum disorder CRP Maternal CRP |
| title | C reactive protein elevation among children or among mothers’ of children with autism during pregnancy, a review and meta-analysis |
| title_full | C reactive protein elevation among children or among mothers’ of children with autism during pregnancy, a review and meta-analysis |
| title_fullStr | C reactive protein elevation among children or among mothers’ of children with autism during pregnancy, a review and meta-analysis |
| title_full_unstemmed | C reactive protein elevation among children or among mothers’ of children with autism during pregnancy, a review and meta-analysis |
| title_short | C reactive protein elevation among children or among mothers’ of children with autism during pregnancy, a review and meta-analysis |
| title_sort | c reactive protein elevation among children or among mothers of children with autism during pregnancy a review and meta analysis |
| topic | ASD Autism Autism spectrum disorder CRP Maternal CRP |
| url | http://link.springer.com/article/10.1186/s12888-020-02619-8 |
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