Modelling optimal use of temporarily restricted colonoscopy capacity in a FIT-based CRC screening program: Application during the COVID-19 pandemic.
<h4>Objective</h4>The COVID-19 pandemic forced colorectal cancer (CRC) screening programs to downscale their colonoscopy capacity. In this study, we assessed strategies to deal with temporary restricted colonoscopy capacity in a FIT-based CRC screening program while aiming to retain the...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0270223 |
| _version_ | 1828403368870019072 |
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| author | Lucie de Jonge Hilliene J van de Schootbrugge-Vandermeer Emilie C H Breekveldt Manon C W Spaander Hanneke J van Vuuren Folkert J van Kemenade Evelien Dekker Iris D Nagtegaal Monique E van Leerdam Iris Lansdorp-Vogelaar |
| author_facet | Lucie de Jonge Hilliene J van de Schootbrugge-Vandermeer Emilie C H Breekveldt Manon C W Spaander Hanneke J van Vuuren Folkert J van Kemenade Evelien Dekker Iris D Nagtegaal Monique E van Leerdam Iris Lansdorp-Vogelaar |
| author_sort | Lucie de Jonge |
| collection | DOAJ |
| description | <h4>Objective</h4>The COVID-19 pandemic forced colorectal cancer (CRC) screening programs to downscale their colonoscopy capacity. In this study, we assessed strategies to deal with temporary restricted colonoscopy capacity in a FIT-based CRC screening program while aiming to retain the maximum possible preventive effect of the screening program.<h4>Design</h4>We simulated the Dutch national CRC screening program inviting individuals between ages 55 and 75 for biennial FIT using the MISCAN-Colon model including the 3-month disruption in the first half of 2020 due to the COVID-19 pandemic. For the second half of 2020 and 2021, we simulated three different strategies for the total target population: 1) increasing the FIT cut-off, 2) skipping one screening for specific screening ages, and 3) extending the screening interval. We estimated the impact on required colonoscopy capacity in 2020-2021 and life years (LYs) lost in the long-term.<h4>Results</h4>Increasing the FIT cut-off, skipping screening ages and extending the screening interval resulted in a maximum reduction of 25,100 (-17.0%), 16,100(-10.9%) and 19,000 (-12.9%) colonoscopies, respectively. Modelling an increased FIT cut-off, the number of LYs lost ranged between 1,400 and 4,400. Skipping just a single screening age resulted in approximately 2,700 LYs lost and this was doubled in case of skipping two screening ages. Extending the screening interval up to 34 months had the smallest impact on LYs lost (up to 1,100 LYs lost).<h4>Conclusion</h4>This modelling study shows that to anticipate on restricted colonoscopy capacity, temporarily extending the screening interval retains the maximum possible preventive effect of the CRC screening program. |
| first_indexed | 2024-12-10T10:16:44Z |
| format | Article |
| id | doaj.art-17677e3c145d4481adebbd43a2ef36b8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T10:16:44Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-17677e3c145d4481adebbd43a2ef36b82022-12-22T01:52:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01176e027022310.1371/journal.pone.0270223Modelling optimal use of temporarily restricted colonoscopy capacity in a FIT-based CRC screening program: Application during the COVID-19 pandemic.Lucie de JongeHilliene J van de Schootbrugge-VandermeerEmilie C H BreekveldtManon C W SpaanderHanneke J van VuurenFolkert J van KemenadeEvelien DekkerIris D NagtegaalMonique E van LeerdamIris Lansdorp-Vogelaar<h4>Objective</h4>The COVID-19 pandemic forced colorectal cancer (CRC) screening programs to downscale their colonoscopy capacity. In this study, we assessed strategies to deal with temporary restricted colonoscopy capacity in a FIT-based CRC screening program while aiming to retain the maximum possible preventive effect of the screening program.<h4>Design</h4>We simulated the Dutch national CRC screening program inviting individuals between ages 55 and 75 for biennial FIT using the MISCAN-Colon model including the 3-month disruption in the first half of 2020 due to the COVID-19 pandemic. For the second half of 2020 and 2021, we simulated three different strategies for the total target population: 1) increasing the FIT cut-off, 2) skipping one screening for specific screening ages, and 3) extending the screening interval. We estimated the impact on required colonoscopy capacity in 2020-2021 and life years (LYs) lost in the long-term.<h4>Results</h4>Increasing the FIT cut-off, skipping screening ages and extending the screening interval resulted in a maximum reduction of 25,100 (-17.0%), 16,100(-10.9%) and 19,000 (-12.9%) colonoscopies, respectively. Modelling an increased FIT cut-off, the number of LYs lost ranged between 1,400 and 4,400. Skipping just a single screening age resulted in approximately 2,700 LYs lost and this was doubled in case of skipping two screening ages. Extending the screening interval up to 34 months had the smallest impact on LYs lost (up to 1,100 LYs lost).<h4>Conclusion</h4>This modelling study shows that to anticipate on restricted colonoscopy capacity, temporarily extending the screening interval retains the maximum possible preventive effect of the CRC screening program.https://doi.org/10.1371/journal.pone.0270223 |
| spellingShingle | Lucie de Jonge Hilliene J van de Schootbrugge-Vandermeer Emilie C H Breekveldt Manon C W Spaander Hanneke J van Vuuren Folkert J van Kemenade Evelien Dekker Iris D Nagtegaal Monique E van Leerdam Iris Lansdorp-Vogelaar Modelling optimal use of temporarily restricted colonoscopy capacity in a FIT-based CRC screening program: Application during the COVID-19 pandemic. PLoS ONE |
| title | Modelling optimal use of temporarily restricted colonoscopy capacity in a FIT-based CRC screening program: Application during the COVID-19 pandemic. |
| title_full | Modelling optimal use of temporarily restricted colonoscopy capacity in a FIT-based CRC screening program: Application during the COVID-19 pandemic. |
| title_fullStr | Modelling optimal use of temporarily restricted colonoscopy capacity in a FIT-based CRC screening program: Application during the COVID-19 pandemic. |
| title_full_unstemmed | Modelling optimal use of temporarily restricted colonoscopy capacity in a FIT-based CRC screening program: Application during the COVID-19 pandemic. |
| title_short | Modelling optimal use of temporarily restricted colonoscopy capacity in a FIT-based CRC screening program: Application during the COVID-19 pandemic. |
| title_sort | modelling optimal use of temporarily restricted colonoscopy capacity in a fit based crc screening program application during the covid 19 pandemic |
| url | https://doi.org/10.1371/journal.pone.0270223 |
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