Causal association between mTOR-dependent circulating protein levels and central precocious puberty: a Mendelian randomization study
BackgroundThe mechanistic target of rapamycin (mTOR) signaling pathway has a significant effect on central precocious puberty (CPP). However, the causality between mTOR-dependent circulating protein levels and CPP is still unclear. Our aim is to assess the effects of seven mTOR-dependent circulating...
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| Format: | Article |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1360043/full |
| _version_ | 1797271436289638400 |
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| author | Yuanxiao Ying Ze Yu Liping Wu |
| author_facet | Yuanxiao Ying Ze Yu Liping Wu |
| author_sort | Yuanxiao Ying |
| collection | DOAJ |
| description | BackgroundThe mechanistic target of rapamycin (mTOR) signaling pathway has a significant effect on central precocious puberty (CPP). However, the causality between mTOR-dependent circulating protein levels and CPP is still unclear. Our aim is to assess the effects of seven mTOR-dependent circulating protein levels on CPP using Mendelian randomization (MR).MethodsInstrumental variables (IVs) for mTOR-dependent circulating protein levels were retrieved from the proteomics-GWAS INTERVAL study and eQTLGen. The summary-level genetic datasets for CPP outcome were obtained from the FinnGen Consortium. Inverse-variance weighted (IVW) was used as the primary method and the pleiotropy, heterogeneity and robustness of the analyses were detected as sensitivity analysis. Positive exposures in the discovery cohort would be revalidated in the validation cohort.ResultsThis two-sample MR study revealed a causal association between eIF4G level in plasma and CPP in both discovery cohort (IVW: OR = 0.45, 95% CI = 0.22–0.91, p = 0.026) and validation cohort (IVW: OR = 0.45, 95% CI = 0.24–0.85, p = 0.014).ConclusionsThere was a causal association between eIF4G level in plasma and CPP. Whether eIF4G can be used for the prevention or treatment of CPP needs to be explored in further studies. |
| first_indexed | 2024-03-07T14:02:42Z |
| format | Article |
| id | doaj.art-176c1941348c497b966cd31e514012e9 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-07T14:02:42Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-176c1941348c497b966cd31e514012e92024-03-07T04:36:20ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-03-011510.3389/fendo.2024.13600431360043Causal association between mTOR-dependent circulating protein levels and central precocious puberty: a Mendelian randomization studyYuanxiao Ying0Ze Yu1Liping Wu2Department of Pediatrics, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, ChinaLaboratory of Cytobiology & Molecular Biology, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, ChinaScience and Education Section, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, ChinaBackgroundThe mechanistic target of rapamycin (mTOR) signaling pathway has a significant effect on central precocious puberty (CPP). However, the causality between mTOR-dependent circulating protein levels and CPP is still unclear. Our aim is to assess the effects of seven mTOR-dependent circulating protein levels on CPP using Mendelian randomization (MR).MethodsInstrumental variables (IVs) for mTOR-dependent circulating protein levels were retrieved from the proteomics-GWAS INTERVAL study and eQTLGen. The summary-level genetic datasets for CPP outcome were obtained from the FinnGen Consortium. Inverse-variance weighted (IVW) was used as the primary method and the pleiotropy, heterogeneity and robustness of the analyses were detected as sensitivity analysis. Positive exposures in the discovery cohort would be revalidated in the validation cohort.ResultsThis two-sample MR study revealed a causal association between eIF4G level in plasma and CPP in both discovery cohort (IVW: OR = 0.45, 95% CI = 0.22–0.91, p = 0.026) and validation cohort (IVW: OR = 0.45, 95% CI = 0.24–0.85, p = 0.014).ConclusionsThere was a causal association between eIF4G level in plasma and CPP. Whether eIF4G can be used for the prevention or treatment of CPP needs to be explored in further studies.https://www.frontiersin.org/articles/10.3389/fendo.2024.1360043/fullcausal relationshipcentral precocious pubertyeIF4GMendelian randomizationmTOR |
| spellingShingle | Yuanxiao Ying Ze Yu Liping Wu Causal association between mTOR-dependent circulating protein levels and central precocious puberty: a Mendelian randomization study Frontiers in Endocrinology causal relationship central precocious puberty eIF4G Mendelian randomization mTOR |
| title | Causal association between mTOR-dependent circulating protein levels and central precocious puberty: a Mendelian randomization study |
| title_full | Causal association between mTOR-dependent circulating protein levels and central precocious puberty: a Mendelian randomization study |
| title_fullStr | Causal association between mTOR-dependent circulating protein levels and central precocious puberty: a Mendelian randomization study |
| title_full_unstemmed | Causal association between mTOR-dependent circulating protein levels and central precocious puberty: a Mendelian randomization study |
| title_short | Causal association between mTOR-dependent circulating protein levels and central precocious puberty: a Mendelian randomization study |
| title_sort | causal association between mtor dependent circulating protein levels and central precocious puberty a mendelian randomization study |
| topic | causal relationship central precocious puberty eIF4G Mendelian randomization mTOR |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1360043/full |
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