Pocket ACEs: Discovering new function within an old player
Angiotensin-converting enzyme (ACE) is canonically known for its role in the renin-angiotensin system (RAS) where its conversion of angiotensin I (Ang I) to the bioactive peptide angiotensin II (Ang II) helps to regulate blood pressure, electrolyte, and volume homeostasis. Further studies on ACE hav...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1151908/full |
| _version_ | 1811155470390394880 |
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| author | Matthew Leong Xiaomo Li Manita Chaum |
| author_facet | Matthew Leong Xiaomo Li Manita Chaum |
| author_sort | Matthew Leong |
| collection | DOAJ |
| description | Angiotensin-converting enzyme (ACE) is canonically known for its role in the renin-angiotensin system (RAS) where its conversion of angiotensin I (Ang I) to the bioactive peptide angiotensin II (Ang II) helps to regulate blood pressure, electrolyte, and volume homeostasis. Further studies on ACE have shown that its enzymatic activity is relatively non-specific and functions outside of the RAS axis. Of the multiple systems it has been implicated in, ACE has been found to play an important role in the development and modulation of hematopoiesis and the immune system, both through the RAS and independently of the RAS axis. |
| first_indexed | 2024-04-10T04:34:23Z |
| format | Article |
| id | doaj.art-176d6d28d33b4fd894c536770ef508cc |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-10T04:34:23Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-176d6d28d33b4fd894c536770ef508cc2023-03-10T04:38:00ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-03-011410.3389/fphys.2023.11519081151908Pocket ACEs: Discovering new function within an old playerMatthew LeongXiaomo LiManita ChaumAngiotensin-converting enzyme (ACE) is canonically known for its role in the renin-angiotensin system (RAS) where its conversion of angiotensin I (Ang I) to the bioactive peptide angiotensin II (Ang II) helps to regulate blood pressure, electrolyte, and volume homeostasis. Further studies on ACE have shown that its enzymatic activity is relatively non-specific and functions outside of the RAS axis. Of the multiple systems it has been implicated in, ACE has been found to play an important role in the development and modulation of hematopoiesis and the immune system, both through the RAS and independently of the RAS axis.https://www.frontiersin.org/articles/10.3389/fphys.2023.1151908/fullACEmacrophagehemato- and immunological effectsneutrophilanti inflammationimmunmodulation |
| spellingShingle | Matthew Leong Xiaomo Li Manita Chaum Pocket ACEs: Discovering new function within an old player Frontiers in Physiology ACE macrophage hemato- and immunological effects neutrophil anti inflammation immunmodulation |
| title | Pocket ACEs: Discovering new function within an old player |
| title_full | Pocket ACEs: Discovering new function within an old player |
| title_fullStr | Pocket ACEs: Discovering new function within an old player |
| title_full_unstemmed | Pocket ACEs: Discovering new function within an old player |
| title_short | Pocket ACEs: Discovering new function within an old player |
| title_sort | pocket aces discovering new function within an old player |
| topic | ACE macrophage hemato- and immunological effects neutrophil anti inflammation immunmodulation |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1151908/full |
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