Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas: Real-Life Data over Three Years
Line-field confocal optical coherence tomography (LC-OCT) can help the clinical diagnosis of skin diseases. The present study aimed to evaluate the sensitivity, specificity, and diagnostic accuracy of LC-OCT for the diagnosis of the most frequent non-melanoma skin cancers (NMSCs), i.e., basal cell c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/30/10/639 |
| _version_ | 1797574186013556736 |
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| author | Carolina Donelli Mariano Suppa Linda Tognetti Jean Luc Perrot Laura Calabrese Javiera Pérez-Anker Josep Malvehy Pietro Rubegni Elisa Cinotti |
| author_facet | Carolina Donelli Mariano Suppa Linda Tognetti Jean Luc Perrot Laura Calabrese Javiera Pérez-Anker Josep Malvehy Pietro Rubegni Elisa Cinotti |
| author_sort | Carolina Donelli |
| collection | DOAJ |
| description | Line-field confocal optical coherence tomography (LC-OCT) can help the clinical diagnosis of skin diseases. The present study aimed to evaluate the sensitivity, specificity, and diagnostic accuracy of LC-OCT for the diagnosis of the most frequent non-melanoma skin cancers (NMSCs), i.e., basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Comparing LC-OCT diagnostic performances with those of dermoscopy, histopathological examination was used as a gold standard. For every study endpoint, the diagnostic ability of LC-OCT revealed superiority over the dermoscopic examination. In particular, a significant increase in specificity was observed. Sensitivity, specificity, and diagnostic accuracy of dermoscopy and LC-OCT for the diagnosis of malignancy were, respectively, 0.97 (CI 0.94–0.99), 0.43 (CI 0.36–0.51), and 0.77 (CI 0.72–0.81) for dermoscopy and 0.99 (CI 0.97–1.00), 0.90 (CI 0.84–0.94), and 0.96 (CI 0.93–0.97) for LC-OCT. The positive predictive value (PPV) resulted in 0.74 (CI 0.69–0.78) for dermoscopy and 0.94 (CI 0.91–0.97) for LC-OCT, and the negative predictive value (NPV) was 0.89 (CI 0.81–0.95) for dermoscopy and 0.98 (CI 0.95–1.00) for LC-OCT. Finally, our real-life study showed a potentially important role of LC-OCT in the non-invasive diagnosis of NMSCs, especially BCC. The real-time imaging technique could spare unnecessary biopsies with an increased sensitivity, a much higher specificity, and better accuracy than clinical assessment with dermoscopy alone. |
| first_indexed | 2024-03-10T21:19:15Z |
| format | Article |
| id | doaj.art-176ef05c48944b19b22911a411f9f5d8 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-10T21:19:15Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-176ef05c48944b19b22911a411f9f5d82023-11-19T16:10:44ZengMDPI AGCurrent Oncology1198-00521718-77292023-09-0130108853886410.3390/curroncol30100639Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas: Real-Life Data over Three YearsCarolina Donelli0Mariano Suppa1Linda Tognetti2Jean Luc Perrot3Laura Calabrese4Javiera Pérez-Anker5Josep Malvehy6Pietro Rubegni7Elisa Cinotti8Department of Medical, Surgical and Neurological Sciences, Dermatology Section, University of Siena, 53100 Siena, ItalyGroupe d’Imagerie Cutanée Non Invasive (GICNI), Société Française de Dermatologie (SFD), 75008 Paris, FranceDepartment of Medical, Surgical and Neurological Sciences, Dermatology Section, University of Siena, 53100 Siena, ItalyGroupe d’Imagerie Cutanée Non Invasive (GICNI), Société Française de Dermatologie (SFD), 75008 Paris, FranceDepartment of Medical, Surgical and Neurological Sciences, Dermatology Section, University of Siena, 53100 Siena, ItalyMelanoma Unit, Dermatology Department, Hospital Clínic de Barcelona, IDIBAPS, Universitat de Barcelona, 08001 Barcelona, SpainMelanoma Unit, Dermatology Department, Hospital Clínic de Barcelona, IDIBAPS, Universitat de Barcelona, 08001 Barcelona, SpainDepartment of Medical, Surgical and Neurological Sciences, Dermatology Section, University of Siena, 53100 Siena, ItalyDepartment of Medical, Surgical and Neurological Sciences, Dermatology Section, University of Siena, 53100 Siena, ItalyLine-field confocal optical coherence tomography (LC-OCT) can help the clinical diagnosis of skin diseases. The present study aimed to evaluate the sensitivity, specificity, and diagnostic accuracy of LC-OCT for the diagnosis of the most frequent non-melanoma skin cancers (NMSCs), i.e., basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Comparing LC-OCT diagnostic performances with those of dermoscopy, histopathological examination was used as a gold standard. For every study endpoint, the diagnostic ability of LC-OCT revealed superiority over the dermoscopic examination. In particular, a significant increase in specificity was observed. Sensitivity, specificity, and diagnostic accuracy of dermoscopy and LC-OCT for the diagnosis of malignancy were, respectively, 0.97 (CI 0.94–0.99), 0.43 (CI 0.36–0.51), and 0.77 (CI 0.72–0.81) for dermoscopy and 0.99 (CI 0.97–1.00), 0.90 (CI 0.84–0.94), and 0.96 (CI 0.93–0.97) for LC-OCT. The positive predictive value (PPV) resulted in 0.74 (CI 0.69–0.78) for dermoscopy and 0.94 (CI 0.91–0.97) for LC-OCT, and the negative predictive value (NPV) was 0.89 (CI 0.81–0.95) for dermoscopy and 0.98 (CI 0.95–1.00) for LC-OCT. Finally, our real-life study showed a potentially important role of LC-OCT in the non-invasive diagnosis of NMSCs, especially BCC. The real-time imaging technique could spare unnecessary biopsies with an increased sensitivity, a much higher specificity, and better accuracy than clinical assessment with dermoscopy alone.https://www.mdpi.com/1718-7729/30/10/639LC-OCToptical coherence tomographybasal cell carcinomasquamous cell carcinomanon-melanoma skin cancersensitivity |
| spellingShingle | Carolina Donelli Mariano Suppa Linda Tognetti Jean Luc Perrot Laura Calabrese Javiera Pérez-Anker Josep Malvehy Pietro Rubegni Elisa Cinotti Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas: Real-Life Data over Three Years Current Oncology LC-OCT optical coherence tomography basal cell carcinoma squamous cell carcinoma non-melanoma skin cancer sensitivity |
| title | Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas: Real-Life Data over Three Years |
| title_full | Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas: Real-Life Data over Three Years |
| title_fullStr | Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas: Real-Life Data over Three Years |
| title_full_unstemmed | Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas: Real-Life Data over Three Years |
| title_short | Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas: Real-Life Data over Three Years |
| title_sort | line field confocal optical coherence tomography for the diagnosis of skin carcinomas real life data over three years |
| topic | LC-OCT optical coherence tomography basal cell carcinoma squamous cell carcinoma non-melanoma skin cancer sensitivity |
| url | https://www.mdpi.com/1718-7729/30/10/639 |
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