Potential Benefits of N-Acetylcysteine in Preventing Pregabalin-Induced Seeking-Like Behavior
Substance-use disorder is globally prevalent and responsible for numerous social and medical problems. Pregabalin (Lyrica), typically used to treat diabetic neuropathy, has recently emerged as a drug of abuse. Drug abuse is associated with several neuronal changes, including the downregulation of gl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/9/4/376 |
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| author | Atiah H. Almalki Hashem O. Alsaab Walaa F. Alsanie Ahmed Gaber Turki Alkhalifa Ahmad Almalki Omar Alzahrani Ana Maria Gregio Hardy Qasim Alhadidi Zahoor A. Shah Yusuf S. Althobaiti |
| author_facet | Atiah H. Almalki Hashem O. Alsaab Walaa F. Alsanie Ahmed Gaber Turki Alkhalifa Ahmad Almalki Omar Alzahrani Ana Maria Gregio Hardy Qasim Alhadidi Zahoor A. Shah Yusuf S. Althobaiti |
| author_sort | Atiah H. Almalki |
| collection | DOAJ |
| description | Substance-use disorder is globally prevalent and responsible for numerous social and medical problems. Pregabalin (Lyrica), typically used to treat diabetic neuropathy, has recently emerged as a drug of abuse. Drug abuse is associated with several neuronal changes, including the downregulation of glutamate transporters such as glutamate transporter 1 and cystine/glutamate antiporter. We investigated the effects of N-acetylcysteine, a glutamate transporter 1 and xCT upregulator, on pregabalin addiction using a conditioned place preference paradigm. Pregabalin (60 mg/kg) was found to induce conditioned place preference when compared to a vehicle. A 100 mg/kg dose of N-acetylcysteine was found to block pregabalin-seeking behaviors. These results support previous findings showing that glutamate transporters play an important role in pregabalin-induced seeking behaviors. N-acetylcysteine may represent a beneficial agent in preventing the abuse potential of pregabalin. |
| first_indexed | 2024-03-10T12:49:02Z |
| format | Article |
| id | doaj.art-176feaa3293c4422a2c4a406fd134cc0 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-10T12:49:02Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-176feaa3293c4422a2c4a406fd134cc02023-11-21T13:12:56ZengMDPI AGHealthcare2227-90322021-03-019437610.3390/healthcare9040376Potential Benefits of N-Acetylcysteine in Preventing Pregabalin-Induced Seeking-Like BehaviorAtiah H. Almalki0Hashem O. Alsaab1Walaa F. Alsanie2Ahmed Gaber3Turki Alkhalifa4Ahmad Almalki5Omar Alzahrani6Ana Maria Gregio Hardy7Qasim Alhadidi8Zahoor A. Shah9Yusuf S. Althobaiti10Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi ArabiaAddiction and Neuroscience Research Unit, Taif University, P.O. Box 11099, Taif 21944, Saudi ArabiaAddiction and Neuroscience Research Unit, Taif University, P.O. Box 11099, Taif 21944, Saudi ArabiaAddiction and Neuroscience Research Unit, Taif University, P.O. Box 11099, Taif 21944, Saudi ArabiaMinistry of Interior, General Directorate of Narcotics Control, General Administration for Precursors and Laboratories, Riyadh 11564, Saudi ArabiaMinistry of Interior, General Directorate of Narcotics Control, General Administration for Precursors and Laboratories, Riyadh 11564, Saudi ArabiaAddiction and Neuroscience Research Unit, Taif University, P.O. Box 11099, Taif 21944, Saudi ArabiaDepartment of Physiology and Pharmacology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USADepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford Medical School, Stanford University, Stanford, CA 94305, USADepartment of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614, USAAddiction and Neuroscience Research Unit, Taif University, P.O. Box 11099, Taif 21944, Saudi ArabiaSubstance-use disorder is globally prevalent and responsible for numerous social and medical problems. Pregabalin (Lyrica), typically used to treat diabetic neuropathy, has recently emerged as a drug of abuse. Drug abuse is associated with several neuronal changes, including the downregulation of glutamate transporters such as glutamate transporter 1 and cystine/glutamate antiporter. We investigated the effects of N-acetylcysteine, a glutamate transporter 1 and xCT upregulator, on pregabalin addiction using a conditioned place preference paradigm. Pregabalin (60 mg/kg) was found to induce conditioned place preference when compared to a vehicle. A 100 mg/kg dose of N-acetylcysteine was found to block pregabalin-seeking behaviors. These results support previous findings showing that glutamate transporters play an important role in pregabalin-induced seeking behaviors. N-acetylcysteine may represent a beneficial agent in preventing the abuse potential of pregabalin.https://www.mdpi.com/2227-9032/9/4/376NACpregabalinaddictionGLT-1xCTCPP |
| spellingShingle | Atiah H. Almalki Hashem O. Alsaab Walaa F. Alsanie Ahmed Gaber Turki Alkhalifa Ahmad Almalki Omar Alzahrani Ana Maria Gregio Hardy Qasim Alhadidi Zahoor A. Shah Yusuf S. Althobaiti Potential Benefits of N-Acetylcysteine in Preventing Pregabalin-Induced Seeking-Like Behavior Healthcare NAC pregabalin addiction GLT-1 xCT CPP |
| title | Potential Benefits of N-Acetylcysteine in Preventing Pregabalin-Induced Seeking-Like Behavior |
| title_full | Potential Benefits of N-Acetylcysteine in Preventing Pregabalin-Induced Seeking-Like Behavior |
| title_fullStr | Potential Benefits of N-Acetylcysteine in Preventing Pregabalin-Induced Seeking-Like Behavior |
| title_full_unstemmed | Potential Benefits of N-Acetylcysteine in Preventing Pregabalin-Induced Seeking-Like Behavior |
| title_short | Potential Benefits of N-Acetylcysteine in Preventing Pregabalin-Induced Seeking-Like Behavior |
| title_sort | potential benefits of n acetylcysteine in preventing pregabalin induced seeking like behavior |
| topic | NAC pregabalin addiction GLT-1 xCT CPP |
| url | https://www.mdpi.com/2227-9032/9/4/376 |
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