Macular Edema Formation and Deterioration of Retinal Function after Intravitreal Bevacizumab Injection for Proliferative Diabetic Retinopathy
Purpose: To report a case of proliferative diabetic retinopathy (PDR) showing transient macular edema (ME) and deteriorated retinal function after intravitreal bevacizumab injection (IVB). Methods and Results: A 53-year-old man received IVB (1.25 mg/0.05 ml) in both eyes for the treatment of PDR. Th...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2011-09-01
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| Series: | Case Reports in Ophthalmology |
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| Online Access: | http://www.karger.com/Article/FullText/332830 |
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| author | Hisanori Imai Shigeru Honda Yasutomo Tsukahara Akira Negi |
| author_facet | Hisanori Imai Shigeru Honda Yasutomo Tsukahara Akira Negi |
| author_sort | Hisanori Imai |
| collection | DOAJ |
| description | Purpose: To report a case of proliferative diabetic retinopathy (PDR) showing transient macular edema (ME) and deteriorated retinal function after intravitreal bevacizumab injection (IVB). Methods and Results: A 53-year-old man received IVB (1.25 mg/0.05 ml) in both eyes for the treatment of PDR. There was no treatment-related complication. However, he complained of photopsia in both eyes 6 h after the injection. Slit-lamp examination revealed mild cellular infiltrations (1+) in the anterior chamber in both eyes. Optical coherence tomography showed ME formation in the left eye. Both full-field and multifocal electroretinography (ERG) revealed the deterioration of all parameters in both eyes compared with pretreatment. The inflammation in the anterior segment and ME disappeared 1 day after the injection. ERG parameters were improved 9 days after the injection, except for the N1 and P1 amplitude of multifocal ERG in the left eye. Conclusion: We propose that patients who undergo IVB should be carefully informed and followed up for possible complications including temporal ME formation and retinal function deterioration. |
| first_indexed | 2024-12-23T14:45:09Z |
| format | Article |
| id | doaj.art-1770e85b8ef944e381ab82e033ddaba3 |
| institution | Directory Open Access Journal |
| issn | 1663-2699 |
| language | English |
| last_indexed | 2024-12-23T14:45:09Z |
| publishDate | 2011-09-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Ophthalmology |
| spelling | doaj.art-1770e85b8ef944e381ab82e033ddaba32022-12-21T17:43:07ZengKarger PublishersCase Reports in Ophthalmology1663-26992011-09-012331431810.1159/000332830332830Macular Edema Formation and Deterioration of Retinal Function after Intravitreal Bevacizumab Injection for Proliferative Diabetic RetinopathyHisanori ImaiShigeru HondaYasutomo TsukaharaAkira NegiPurpose: To report a case of proliferative diabetic retinopathy (PDR) showing transient macular edema (ME) and deteriorated retinal function after intravitreal bevacizumab injection (IVB). Methods and Results: A 53-year-old man received IVB (1.25 mg/0.05 ml) in both eyes for the treatment of PDR. There was no treatment-related complication. However, he complained of photopsia in both eyes 6 h after the injection. Slit-lamp examination revealed mild cellular infiltrations (1+) in the anterior chamber in both eyes. Optical coherence tomography showed ME formation in the left eye. Both full-field and multifocal electroretinography (ERG) revealed the deterioration of all parameters in both eyes compared with pretreatment. The inflammation in the anterior segment and ME disappeared 1 day after the injection. ERG parameters were improved 9 days after the injection, except for the N1 and P1 amplitude of multifocal ERG in the left eye. Conclusion: We propose that patients who undergo IVB should be carefully informed and followed up for possible complications including temporal ME formation and retinal function deterioration.http://www.karger.com/Article/FullText/332830Anti-vascular endothelial growth factorBevacizumabAvastinMultifocal electroretinographyFull-field electroretinographyDiabetic retinopathyOptical coherence tomographyMacular edema |
| spellingShingle | Hisanori Imai Shigeru Honda Yasutomo Tsukahara Akira Negi Macular Edema Formation and Deterioration of Retinal Function after Intravitreal Bevacizumab Injection for Proliferative Diabetic Retinopathy Case Reports in Ophthalmology Anti-vascular endothelial growth factor Bevacizumab Avastin Multifocal electroretinography Full-field electroretinography Diabetic retinopathy Optical coherence tomography Macular edema |
| title | Macular Edema Formation and Deterioration of Retinal Function after Intravitreal Bevacizumab Injection for Proliferative Diabetic Retinopathy |
| title_full | Macular Edema Formation and Deterioration of Retinal Function after Intravitreal Bevacizumab Injection for Proliferative Diabetic Retinopathy |
| title_fullStr | Macular Edema Formation and Deterioration of Retinal Function after Intravitreal Bevacizumab Injection for Proliferative Diabetic Retinopathy |
| title_full_unstemmed | Macular Edema Formation and Deterioration of Retinal Function after Intravitreal Bevacizumab Injection for Proliferative Diabetic Retinopathy |
| title_short | Macular Edema Formation and Deterioration of Retinal Function after Intravitreal Bevacizumab Injection for Proliferative Diabetic Retinopathy |
| title_sort | macular edema formation and deterioration of retinal function after intravitreal bevacizumab injection for proliferative diabetic retinopathy |
| topic | Anti-vascular endothelial growth factor Bevacizumab Avastin Multifocal electroretinography Full-field electroretinography Diabetic retinopathy Optical coherence tomography Macular edema |
| url | http://www.karger.com/Article/FullText/332830 |
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