Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system

Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system

Abstract Background Alzheimer’s disease is a neurodegenerative disease characterized by the interstitial deposition of amyloid β (Aβ) plaque, which is thought to be related to chronic neuroinflammation. Aβ is known to make fibrils via oligomers from monomers. Aβ has been reported to activate the NLR...

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Dettagli Bibliografici
Autori principali: Ayaka Nakanishi, Naoe Kaneko, Hiroyuki Takeda, Tatsuya Sawasaki, Shinnosuke Morikawa, Wei Zhou, Mie Kurata, Toshihiro Yamamoto, Sheikh Mohammad Fazle Akbar, Tamotsu Zako, Junya Masumoto
Natura: Articolo
Lingua:English
Pubblicazione: BMC 2018-11-01
Serie:Inflammation and Regeneration
Soggetti:
Alzheimer’s disease
Amyloid β
NLRP3
Interleukin-1β
Inflammasome
Cell-free
Accesso online:http://link.springer.com/article/10.1186/s41232-018-0085-6

Accesso online

http://link.springer.com/article/10.1186/s41232-018-0085-6

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