Subthalamic nucleus high-frequency stimulation restores altered electrophysiological properties of cortical neurons in parkinsonian rat.
Electrophysiological recordings performed in parkinsonian patients and animal models have confirmed the occurrence of alterations in firing rate and pattern of basal ganglia neurons, but the outcome of these changes in thalamo-cortical networks remains unclear. Using rats rendered parkinsonian, we i...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3877054?pdf=render |
| _version_ | 1819104151701815296 |
|---|---|
| author | Bertrand Degos Jean-Michel Deniau Mario Chavez Nicolas Maurice |
| author_facet | Bertrand Degos Jean-Michel Deniau Mario Chavez Nicolas Maurice |
| author_sort | Bertrand Degos |
| collection | DOAJ |
| description | Electrophysiological recordings performed in parkinsonian patients and animal models have confirmed the occurrence of alterations in firing rate and pattern of basal ganglia neurons, but the outcome of these changes in thalamo-cortical networks remains unclear. Using rats rendered parkinsonian, we investigated, at a cellular level in vivo, the electrophysiological changes induced in the pyramidal cells of the motor cortex by the dopaminergic transmission interruption and further characterized the impact of high-frequency electrical stimulation of the subthalamic nucleus, a procedure alleviating parkinsonian symptoms. We provided evidence that a lesion restricted to the substantia nigra pars compacta resulted in a marked increase in the mean firing rate and bursting pattern of pyramidal neurons of the motor cortex. These alterations were underlain by changes of the electrical membranes properties of pyramidal cells including depolarized resting membrane potential and increased input resistance. The modifications induced by the dopaminergic loss were more pronounced in cortico-striatal than in cortico-subthalamic neurons. Furthermore, subthalamic nucleus high-frequency stimulation applied at parameters alleviating parkinsonian signs regularized the firing pattern of pyramidal cells and restored their electrical membrane properties. |
| first_indexed | 2024-12-22T02:01:48Z |
| format | Article |
| id | doaj.art-1778aeef8b3a44c99fb483b4841f5d38 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T02:01:48Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1778aeef8b3a44c99fb483b4841f5d382022-12-21T18:42:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01812e8360810.1371/journal.pone.0083608Subthalamic nucleus high-frequency stimulation restores altered electrophysiological properties of cortical neurons in parkinsonian rat.Bertrand DegosJean-Michel DeniauMario ChavezNicolas MauriceElectrophysiological recordings performed in parkinsonian patients and animal models have confirmed the occurrence of alterations in firing rate and pattern of basal ganglia neurons, but the outcome of these changes in thalamo-cortical networks remains unclear. Using rats rendered parkinsonian, we investigated, at a cellular level in vivo, the electrophysiological changes induced in the pyramidal cells of the motor cortex by the dopaminergic transmission interruption and further characterized the impact of high-frequency electrical stimulation of the subthalamic nucleus, a procedure alleviating parkinsonian symptoms. We provided evidence that a lesion restricted to the substantia nigra pars compacta resulted in a marked increase in the mean firing rate and bursting pattern of pyramidal neurons of the motor cortex. These alterations were underlain by changes of the electrical membranes properties of pyramidal cells including depolarized resting membrane potential and increased input resistance. The modifications induced by the dopaminergic loss were more pronounced in cortico-striatal than in cortico-subthalamic neurons. Furthermore, subthalamic nucleus high-frequency stimulation applied at parameters alleviating parkinsonian signs regularized the firing pattern of pyramidal cells and restored their electrical membrane properties.http://europepmc.org/articles/PMC3877054?pdf=render |
| spellingShingle | Bertrand Degos Jean-Michel Deniau Mario Chavez Nicolas Maurice Subthalamic nucleus high-frequency stimulation restores altered electrophysiological properties of cortical neurons in parkinsonian rat. PLoS ONE |
| title | Subthalamic nucleus high-frequency stimulation restores altered electrophysiological properties of cortical neurons in parkinsonian rat. |
| title_full | Subthalamic nucleus high-frequency stimulation restores altered electrophysiological properties of cortical neurons in parkinsonian rat. |
| title_fullStr | Subthalamic nucleus high-frequency stimulation restores altered electrophysiological properties of cortical neurons in parkinsonian rat. |
| title_full_unstemmed | Subthalamic nucleus high-frequency stimulation restores altered electrophysiological properties of cortical neurons in parkinsonian rat. |
| title_short | Subthalamic nucleus high-frequency stimulation restores altered electrophysiological properties of cortical neurons in parkinsonian rat. |
| title_sort | subthalamic nucleus high frequency stimulation restores altered electrophysiological properties of cortical neurons in parkinsonian rat |
| url | http://europepmc.org/articles/PMC3877054?pdf=render |
| work_keys_str_mv | AT bertranddegos subthalamicnucleushighfrequencystimulationrestoresalteredelectrophysiologicalpropertiesofcorticalneuronsinparkinsonianrat AT jeanmicheldeniau subthalamicnucleushighfrequencystimulationrestoresalteredelectrophysiologicalpropertiesofcorticalneuronsinparkinsonianrat AT mariochavez subthalamicnucleushighfrequencystimulationrestoresalteredelectrophysiologicalpropertiesofcorticalneuronsinparkinsonianrat AT nicolasmaurice subthalamicnucleushighfrequencystimulationrestoresalteredelectrophysiologicalpropertiesofcorticalneuronsinparkinsonianrat |