A study of changes in inflammatory markers in patients of depression
Background: Depression may result in unfavorable health outcomes as it has been associated with cardiovascular morbidity. Recent researches have suggested the role of inflammation in the pathophysiology of depression and co-morbidities associated with it although the underlying mechanism relating th...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2014-01-01
|
| Series: | Journal of Mental Health and Human Behaviour |
| Subjects: | |
| Online Access: | http://www.jmhhb.org/article.asp?issn=0971-8990;year=2014;volume=19;issue=2;spage=74;epage=77;aulast=Jangpangi |
| _version_ | 1818190150892519424 |
|---|---|
| author | Deepti Jangpangi Sunita Mondal Rajiv Bandhu Dinesh Kataria Jayashree Bhattacharjee Asha Gandhi |
| author_facet | Deepti Jangpangi Sunita Mondal Rajiv Bandhu Dinesh Kataria Jayashree Bhattacharjee Asha Gandhi |
| author_sort | Deepti Jangpangi |
| collection | DOAJ |
| description | Background: Depression may result in unfavorable health outcomes as it has been associated with cardiovascular morbidity. Recent researches have suggested the role of inflammation in the pathophysiology of depression and co-morbidities associated with it although the underlying mechanism relating the two is still unclear. Aim: The present study aimed to explore the association between depression and inflammatory markers including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and high sensitive c-reactive protein (hsCRP). Materials and Methods: Thirty drug-naοve patients of depression diagnosed on the basis of ICD-10 criteria, in the age group of 20-45 years were included in the study. They were compared with 30 age, gender, body mass index, socio-economic and educational status matched apparently healthy controls. The blood samples were taken after an overnight fast and serum samples were immediately stored until the time of analysis. Results: The serum levels of hsCRP were significantly higher (P = 0.042) in depression group as compared to the control group. Although the mean serum levels of IL-6 and TNF-α were higher in patients of depression, they were not statistically significant (IL-6: P = 0.055, TNF-α: P = 0.053). Conclusion: It can be inferred from our study that depression is associated with underlying low-grade inflammation, which might contribute to increased morbidity in patients of depression. |
| first_indexed | 2024-12-11T23:54:09Z |
| format | Article |
| id | doaj.art-177afac59a9e414586ae64296a8d4f4d |
| institution | Directory Open Access Journal |
| issn | 0971-8990 |
| language | English |
| last_indexed | 2024-12-11T23:54:09Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Mental Health and Human Behaviour |
| spelling | doaj.art-177afac59a9e414586ae64296a8d4f4d2022-12-22T00:45:24ZengWolters Kluwer Medknow PublicationsJournal of Mental Health and Human Behaviour0971-89902014-01-01192747710.4103/0971-8990.153714A study of changes in inflammatory markers in patients of depressionDeepti JangpangiSunita MondalRajiv BandhuDinesh KatariaJayashree BhattacharjeeAsha GandhiBackground: Depression may result in unfavorable health outcomes as it has been associated with cardiovascular morbidity. Recent researches have suggested the role of inflammation in the pathophysiology of depression and co-morbidities associated with it although the underlying mechanism relating the two is still unclear. Aim: The present study aimed to explore the association between depression and inflammatory markers including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and high sensitive c-reactive protein (hsCRP). Materials and Methods: Thirty drug-naοve patients of depression diagnosed on the basis of ICD-10 criteria, in the age group of 20-45 years were included in the study. They were compared with 30 age, gender, body mass index, socio-economic and educational status matched apparently healthy controls. The blood samples were taken after an overnight fast and serum samples were immediately stored until the time of analysis. Results: The serum levels of hsCRP were significantly higher (P = 0.042) in depression group as compared to the control group. Although the mean serum levels of IL-6 and TNF-α were higher in patients of depression, they were not statistically significant (IL-6: P = 0.055, TNF-α: P = 0.053). Conclusion: It can be inferred from our study that depression is associated with underlying low-grade inflammation, which might contribute to increased morbidity in patients of depression.http://www.jmhhb.org/article.asp?issn=0971-8990;year=2014;volume=19;issue=2;spage=74;epage=77;aulast=JangpangiDepressionhigh sensitive c-reactive proteininterleukin-6tumor necrosis factor-alpha |
| spellingShingle | Deepti Jangpangi Sunita Mondal Rajiv Bandhu Dinesh Kataria Jayashree Bhattacharjee Asha Gandhi A study of changes in inflammatory markers in patients of depression Journal of Mental Health and Human Behaviour Depression high sensitive c-reactive protein interleukin-6 tumor necrosis factor-alpha |
| title | A study of changes in inflammatory markers in patients of depression |
| title_full | A study of changes in inflammatory markers in patients of depression |
| title_fullStr | A study of changes in inflammatory markers in patients of depression |
| title_full_unstemmed | A study of changes in inflammatory markers in patients of depression |
| title_short | A study of changes in inflammatory markers in patients of depression |
| title_sort | study of changes in inflammatory markers in patients of depression |
| topic | Depression high sensitive c-reactive protein interleukin-6 tumor necrosis factor-alpha |
| url | http://www.jmhhb.org/article.asp?issn=0971-8990;year=2014;volume=19;issue=2;spage=74;epage=77;aulast=Jangpangi |
| work_keys_str_mv | AT deeptijangpangi astudyofchangesininflammatorymarkersinpatientsofdepression AT sunitamondal astudyofchangesininflammatorymarkersinpatientsofdepression AT rajivbandhu astudyofchangesininflammatorymarkersinpatientsofdepression AT dineshkataria astudyofchangesininflammatorymarkersinpatientsofdepression AT jayashreebhattacharjee astudyofchangesininflammatorymarkersinpatientsofdepression AT ashagandhi astudyofchangesininflammatorymarkersinpatientsofdepression AT deeptijangpangi studyofchangesininflammatorymarkersinpatientsofdepression AT sunitamondal studyofchangesininflammatorymarkersinpatientsofdepression AT rajivbandhu studyofchangesininflammatorymarkersinpatientsofdepression AT dineshkataria studyofchangesininflammatorymarkersinpatientsofdepression AT jayashreebhattacharjee studyofchangesininflammatorymarkersinpatientsofdepression AT ashagandhi studyofchangesininflammatorymarkersinpatientsofdepression |