Cancer and Thrombotic Risk: The Platelet Paradigm
Hematologic malignancies and solid tumors increase the risk of venous and arterial thrombosis and contribute greatly to patient morbidity and mortality. Thrombosis occurs when the intricate balance of circulating antithrombotic and prothrombotic blood elements are disrupted. In recent years, the int...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fcvm.2017.00067/full |
| _version_ | 1828772189364551680 |
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| author | Elizabeth C. Lee Elizabeth C. Lee Scott J. Cameron Scott J. Cameron Scott J. Cameron |
| author_facet | Elizabeth C. Lee Elizabeth C. Lee Scott J. Cameron Scott J. Cameron Scott J. Cameron |
| author_sort | Elizabeth C. Lee |
| collection | DOAJ |
| description | Hematologic malignancies and solid tumors increase the risk of venous and arterial thrombosis and contribute greatly to patient morbidity and mortality. Thrombosis occurs when the intricate balance of circulating antithrombotic and prothrombotic blood elements are disrupted. In recent years, the interplay between paraneoplastic cells and platelets has become apparent, with a change in platelet phenotype causing dysregulated platelet activity. This review discusses mechanism of thrombosis in cancer, evidence for using drug therapy, and exciting research efforts to understand and hopefully control aberrant thrombotic events in patients with cancer. |
| first_indexed | 2024-12-11T14:39:15Z |
| format | Article |
| id | doaj.art-177ccb87da694e5f899445df7a1cb80f |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-11T14:39:15Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-177ccb87da694e5f899445df7a1cb80f2022-12-22T01:02:00ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2017-11-01410.3389/fcvm.2017.00067306693Cancer and Thrombotic Risk: The Platelet ParadigmElizabeth C. Lee0Elizabeth C. Lee1Scott J. Cameron2Scott J. Cameron3Scott J. Cameron4Aab Cardiovascular Research Institute, Rochester, NY, United StatesDepartment of Medicine, Division of Cardiology, University of Rochester School of Medicine, Rochester, NY, United StatesAab Cardiovascular Research Institute, Rochester, NY, United StatesDepartment of Medicine, Division of Cardiology, University of Rochester School of Medicine, Rochester, NY, United StatesDepartment of Surgery, Cardiac Surgery, University of Rochester, Rochester, NY, United StatesHematologic malignancies and solid tumors increase the risk of venous and arterial thrombosis and contribute greatly to patient morbidity and mortality. Thrombosis occurs when the intricate balance of circulating antithrombotic and prothrombotic blood elements are disrupted. In recent years, the interplay between paraneoplastic cells and platelets has become apparent, with a change in platelet phenotype causing dysregulated platelet activity. This review discusses mechanism of thrombosis in cancer, evidence for using drug therapy, and exciting research efforts to understand and hopefully control aberrant thrombotic events in patients with cancer.http://journal.frontiersin.org/article/10.3389/fcvm.2017.00067/fullthrombosisplatelet activationplatelet dysfunctioncancer progressiondysregulated plateletsantiocoagulation |
| spellingShingle | Elizabeth C. Lee Elizabeth C. Lee Scott J. Cameron Scott J. Cameron Scott J. Cameron Cancer and Thrombotic Risk: The Platelet Paradigm Frontiers in Cardiovascular Medicine thrombosis platelet activation platelet dysfunction cancer progression dysregulated platelets antiocoagulation |
| title | Cancer and Thrombotic Risk: The Platelet Paradigm |
| title_full | Cancer and Thrombotic Risk: The Platelet Paradigm |
| title_fullStr | Cancer and Thrombotic Risk: The Platelet Paradigm |
| title_full_unstemmed | Cancer and Thrombotic Risk: The Platelet Paradigm |
| title_short | Cancer and Thrombotic Risk: The Platelet Paradigm |
| title_sort | cancer and thrombotic risk the platelet paradigm |
| topic | thrombosis platelet activation platelet dysfunction cancer progression dysregulated platelets antiocoagulation |
| url | http://journal.frontiersin.org/article/10.3389/fcvm.2017.00067/full |
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