Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample

Schizophrenia is a severe psychotic disorder with recurrent relapse and functional impairment. It results from a poorly understood gene-environment interaction. The Taq1A polymorphism (located in the gene cluster NTAD) is a likely candidate for schizophrenia. Its rs1800497 polymorphism was shown to...

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Main Authors: Quirino Cordeiro, Homero Vallada
Format: Article
Language:English
Published: Academia Brasileira de Neurologia (ABNEURO) 2014-08-01
Series:Arquivos de Neuro-Psiquiatria
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000800582&lng=en&tlng=en
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author Quirino Cordeiro
Homero Vallada
author_facet Quirino Cordeiro
Homero Vallada
author_sort Quirino Cordeiro
collection DOAJ
description Schizophrenia is a severe psychotic disorder with recurrent relapse and functional impairment. It results from a poorly understood gene-environment interaction. The Taq1A polymorphism (located in the gene cluster NTAD) is a likely candidate for schizophrenia. Its rs1800497 polymorphism was shown to be associated with DRD2 gene expression. Therefore the present work aims to investigate a possible association between schizophrenia and such polymorphism. The compared distribution of the alleles and genotypes of the studied polymorphism was investigated in a Brazilian sample of 235 patients and 834 controls. Genotypic frequencies were in Hardy-Weinberg equilibrium. There was a trend of allelic association between the Taq1A polymorphism (rs1800497) with schizophrenia in the studied sample. However no statistically differences were found between cases and controls when analyzed by gender or schizophrenia subtypes.
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spelling doaj.art-177e7aaa2d494aa0a19c964b6c4162162022-12-21T23:56:37ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272014-08-0172858258610.1590/0004-282X20140100S0004-282X2014000800582Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sampleQuirino CordeiroHomero ValladaSchizophrenia is a severe psychotic disorder with recurrent relapse and functional impairment. It results from a poorly understood gene-environment interaction. The Taq1A polymorphism (located in the gene cluster NTAD) is a likely candidate for schizophrenia. Its rs1800497 polymorphism was shown to be associated with DRD2 gene expression. Therefore the present work aims to investigate a possible association between schizophrenia and such polymorphism. The compared distribution of the alleles and genotypes of the studied polymorphism was investigated in a Brazilian sample of 235 patients and 834 controls. Genotypic frequencies were in Hardy-Weinberg equilibrium. There was a trend of allelic association between the Taq1A polymorphism (rs1800497) with schizophrenia in the studied sample. However no statistically differences were found between cases and controls when analyzed by gender or schizophrenia subtypes.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000800582&lng=en&tlng=enestudo de associaçãodopaminagenéticapsicose
spellingShingle Quirino Cordeiro
Homero Vallada
Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample
Arquivos de Neuro-Psiquiatria
estudo de associação
dopamina
genética
psicose
title Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample
title_full Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample
title_fullStr Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample
title_full_unstemmed Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample
title_short Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample
title_sort association study between the taq1a rs1800497 polymorphism and schizophrenia in a brazilian sample
topic estudo de associação
dopamina
genética
psicose
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000800582&lng=en&tlng=en
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AT homerovallada associationstudybetweenthetaq1ars1800497polymorphismandschizophreniainabraziliansample