Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample
Schizophrenia is a severe psychotic disorder with recurrent relapse and functional impairment. It results from a poorly understood gene-environment interaction. The Taq1A polymorphism (located in the gene cluster NTAD) is a likely candidate for schizophrenia. Its rs1800497 polymorphism was shown to...
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Format: | Article |
Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2014-08-01
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Series: | Arquivos de Neuro-Psiquiatria |
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Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000800582&lng=en&tlng=en |
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author | Quirino Cordeiro Homero Vallada |
author_facet | Quirino Cordeiro Homero Vallada |
author_sort | Quirino Cordeiro |
collection | DOAJ |
description | Schizophrenia is a severe psychotic disorder with recurrent relapse and functional impairment. It results from a poorly understood gene-environment interaction. The Taq1A polymorphism (located in the gene cluster NTAD) is a likely candidate for schizophrenia. Its rs1800497 polymorphism was shown to be associated with DRD2 gene expression. Therefore the present work aims to investigate a possible association between schizophrenia and such polymorphism. The compared distribution of the alleles and genotypes of the studied polymorphism was investigated in a Brazilian sample of 235 patients and 834 controls. Genotypic frequencies were in Hardy-Weinberg equilibrium. There was a trend of allelic association between the Taq1A polymorphism (rs1800497) with schizophrenia in the studied sample. However no statistically differences were found between cases and controls when analyzed by gender or schizophrenia subtypes. |
first_indexed | 2024-12-13T06:30:16Z |
format | Article |
id | doaj.art-177e7aaa2d494aa0a19c964b6c416216 |
institution | Directory Open Access Journal |
issn | 1678-4227 |
language | English |
last_indexed | 2024-12-13T06:30:16Z |
publishDate | 2014-08-01 |
publisher | Academia Brasileira de Neurologia (ABNEURO) |
record_format | Article |
series | Arquivos de Neuro-Psiquiatria |
spelling | doaj.art-177e7aaa2d494aa0a19c964b6c4162162022-12-21T23:56:37ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272014-08-0172858258610.1590/0004-282X20140100S0004-282X2014000800582Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sampleQuirino CordeiroHomero ValladaSchizophrenia is a severe psychotic disorder with recurrent relapse and functional impairment. It results from a poorly understood gene-environment interaction. The Taq1A polymorphism (located in the gene cluster NTAD) is a likely candidate for schizophrenia. Its rs1800497 polymorphism was shown to be associated with DRD2 gene expression. Therefore the present work aims to investigate a possible association between schizophrenia and such polymorphism. The compared distribution of the alleles and genotypes of the studied polymorphism was investigated in a Brazilian sample of 235 patients and 834 controls. Genotypic frequencies were in Hardy-Weinberg equilibrium. There was a trend of allelic association between the Taq1A polymorphism (rs1800497) with schizophrenia in the studied sample. However no statistically differences were found between cases and controls when analyzed by gender or schizophrenia subtypes.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000800582&lng=en&tlng=enestudo de associaçãodopaminagenéticapsicose |
spellingShingle | Quirino Cordeiro Homero Vallada Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample Arquivos de Neuro-Psiquiatria estudo de associação dopamina genética psicose |
title | Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample |
title_full | Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample |
title_fullStr | Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample |
title_full_unstemmed | Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample |
title_short | Association study between the Taq1A (rs1800497) polymorphism and schizophrenia in a Brazilian sample |
title_sort | association study between the taq1a rs1800497 polymorphism and schizophrenia in a brazilian sample |
topic | estudo de associação dopamina genética psicose |
url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014000800582&lng=en&tlng=en |
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