Stimulation of the Hippocampal POMC/MC4R Circuit Alleviates Synaptic Plasticity Impairment in an Alzheimer’s Disease Model

Stimulation of the Hippocampal POMC/MC4R Circuit Alleviates Synaptic Plasticity Impairment in an Alzheimer’s Disease Model

Hippocampal synaptic plasticity is modulated by neuropeptides, the disruption of which might contribute to cognitive deficits observed in Alzheimer’s disease (AD). Although pro-opiomelanocortin (POMC)-derived neuropeptides and melanocortin 4 receptor (MC4R) are implicated in hippocampus-dependent sy...

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Bibliographic Details
Main Authors: Yang Shen, Min Tian, Yuqiong Zheng, Fei Gong, Amy K.Y. Fu, Nancy Y. Ip
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Cell Reports
Subjects:
hippocampus
synaptic plasticity
synapses
Alzheimer’s disease
memory loss
melanocortin receptor
G protein-coupled receptor
alpha-melanoctye-stimulating hormone
pro-opiomelanocortin
neural circuit
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716314632

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