Rosemary supplementation (Rosmarinus oficinallis L.) attenuates cardiac remodeling after myocardial infarction in rats.
Myocardial infarction (MI) is one of the leading causes of morbidity and mortality worldwide. Dietary intervention on adverse cardiac remodeling after MI has significant clinical relevance. Rosemary leaves are a natural product with antioxidant/anti-inflammatory properties, but its effect on morphol...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5426768?pdf=render |
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| author | Bruna Paola Murino Rafacho Priscila Portugal Dos Santos Andréa de Freitas Gonçalves Ana Angélica Henrique Fernandes Katashi Okoshi Fernanda Chiuso-Minicucci Paula S Azevedo Leonardo Antonio Mamede Zornoff Marcos Ferreira Minicucci Xiang-Dong Wang Sergio Alberto Rupp de Paiva |
| author_facet | Bruna Paola Murino Rafacho Priscila Portugal Dos Santos Andréa de Freitas Gonçalves Ana Angélica Henrique Fernandes Katashi Okoshi Fernanda Chiuso-Minicucci Paula S Azevedo Leonardo Antonio Mamede Zornoff Marcos Ferreira Minicucci Xiang-Dong Wang Sergio Alberto Rupp de Paiva |
| author_sort | Bruna Paola Murino Rafacho |
| collection | DOAJ |
| description | Myocardial infarction (MI) is one of the leading causes of morbidity and mortality worldwide. Dietary intervention on adverse cardiac remodeling after MI has significant clinical relevance. Rosemary leaves are a natural product with antioxidant/anti-inflammatory properties, but its effect on morphology and ventricular function after MI is unknown.To determine the effect of the dietary supplementation of rosemary leaves on cardiac remodeling after MI, male Wistar rats were divided into 6 groups after sham procedure or experimental induced MI: 1) Sham group fed standard chow (SR0, n = 23); 2) Sham group fed standard chow supplemented with 0.02% rosemary (R002) (SR002, n = 23); 3) Sham group fed standard chow supplemented with 0.2% rosemary (R02) (SR02, n = 22); 4) group submitted to MI and fed standard chow (IR0, n = 13); 5) group submitted to MI and fed standard chow supplemented with R002 (IR002, n = 8); and 6) group submitted to MI and fed standard chow supplemented with R02 (IR02, n = 9). After 3 months of the treatment, systolic pressure evaluation, echocardiography and euthanasia were performed. Left ventricular samples were evaluated for: fibrosis, cytokine levels, apoptosis, energy metabolism enzymes, and oxidative stress. Rosemary dietary supplementation attenuated cardiac remodeling by improving energy metabolism and decreasing oxidative stress. Rosemary supplementation of 0.02% improved diastolic function and reduced hypertrophy after MI. Regarding rosemary dose, 0.02% and 0.2% for rats are equivalent to 11 mg and 110 mg for humans, respectively.Our findings support further investigations of the rosemary use as adjuvant therapy in adverse cardiac remodeling. |
| first_indexed | 2024-12-11T09:46:36Z |
| format | Article |
| id | doaj.art-1784f09f09334111be63eada4ce2b119 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T09:46:36Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1784f09f09334111be63eada4ce2b1192022-12-22T01:12:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01125e017752110.1371/journal.pone.0177521Rosemary supplementation (Rosmarinus oficinallis L.) attenuates cardiac remodeling after myocardial infarction in rats.Bruna Paola Murino RafachoPriscila Portugal Dos SantosAndréa de Freitas GonçalvesAna Angélica Henrique FernandesKatashi OkoshiFernanda Chiuso-MinicucciPaula S AzevedoLeonardo Antonio Mamede ZornoffMarcos Ferreira MinicucciXiang-Dong WangSergio Alberto Rupp de PaivaMyocardial infarction (MI) is one of the leading causes of morbidity and mortality worldwide. Dietary intervention on adverse cardiac remodeling after MI has significant clinical relevance. Rosemary leaves are a natural product with antioxidant/anti-inflammatory properties, but its effect on morphology and ventricular function after MI is unknown.To determine the effect of the dietary supplementation of rosemary leaves on cardiac remodeling after MI, male Wistar rats were divided into 6 groups after sham procedure or experimental induced MI: 1) Sham group fed standard chow (SR0, n = 23); 2) Sham group fed standard chow supplemented with 0.02% rosemary (R002) (SR002, n = 23); 3) Sham group fed standard chow supplemented with 0.2% rosemary (R02) (SR02, n = 22); 4) group submitted to MI and fed standard chow (IR0, n = 13); 5) group submitted to MI and fed standard chow supplemented with R002 (IR002, n = 8); and 6) group submitted to MI and fed standard chow supplemented with R02 (IR02, n = 9). After 3 months of the treatment, systolic pressure evaluation, echocardiography and euthanasia were performed. Left ventricular samples were evaluated for: fibrosis, cytokine levels, apoptosis, energy metabolism enzymes, and oxidative stress. Rosemary dietary supplementation attenuated cardiac remodeling by improving energy metabolism and decreasing oxidative stress. Rosemary supplementation of 0.02% improved diastolic function and reduced hypertrophy after MI. Regarding rosemary dose, 0.02% and 0.2% for rats are equivalent to 11 mg and 110 mg for humans, respectively.Our findings support further investigations of the rosemary use as adjuvant therapy in adverse cardiac remodeling.http://europepmc.org/articles/PMC5426768?pdf=render |
| spellingShingle | Bruna Paola Murino Rafacho Priscila Portugal Dos Santos Andréa de Freitas Gonçalves Ana Angélica Henrique Fernandes Katashi Okoshi Fernanda Chiuso-Minicucci Paula S Azevedo Leonardo Antonio Mamede Zornoff Marcos Ferreira Minicucci Xiang-Dong Wang Sergio Alberto Rupp de Paiva Rosemary supplementation (Rosmarinus oficinallis L.) attenuates cardiac remodeling after myocardial infarction in rats. PLoS ONE |
| title | Rosemary supplementation (Rosmarinus oficinallis L.) attenuates cardiac remodeling after myocardial infarction in rats. |
| title_full | Rosemary supplementation (Rosmarinus oficinallis L.) attenuates cardiac remodeling after myocardial infarction in rats. |
| title_fullStr | Rosemary supplementation (Rosmarinus oficinallis L.) attenuates cardiac remodeling after myocardial infarction in rats. |
| title_full_unstemmed | Rosemary supplementation (Rosmarinus oficinallis L.) attenuates cardiac remodeling after myocardial infarction in rats. |
| title_short | Rosemary supplementation (Rosmarinus oficinallis L.) attenuates cardiac remodeling after myocardial infarction in rats. |
| title_sort | rosemary supplementation rosmarinus oficinallis l attenuates cardiac remodeling after myocardial infarction in rats |
| url | http://europepmc.org/articles/PMC5426768?pdf=render |
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