Development of Hif1α pharmacogenomic mutation models to study individual variations in drug action for tumor hypoxia: An in silico approach

Development of Hif1α pharmacogenomic mutation models to study individual variations in drug action for tumor hypoxia: An in silico approach

Objective: Tumor hypoxia, a predominant feature of solid tumor produces drug resistance that significantly impacts a patient's clinical outcomes. Hypoxia-inducible factor 1-alpha (HIF1α) is the major mutation involved in establishing the microenvironment. As a consequence of its involvement in...

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Bibliographic Details
Main Authors: Vaisali Balasubramaniam, P K Krishnan Namboori
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Journal of Pharmacy and Bioallied Sciences
Subjects:
drug response
individual variation
molecular docking
molecular dynamics simulation
mutation models
pharmacogenomics
tumor hypoxia
Online Access:http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=4;spage=387;epage=393;aulast=Balasubramaniam

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