Chemical profiling of smokeless tobacco and their disease association
Background Smokeless tobacco (SLT) products are consumed by millions of people in over 130 countries around the world. SLT products have a large impact on the health of individuals since the products cause several diseases including cancer. Though the smokeless tobacco products have been found to b...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Publishing
2018-03-01
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| Series: | Tobacco Induced Diseases |
| Subjects: | |
| Online Access: | http://www.journalssystem.com/tid/Chemical-profiling-of-smokeless-tobacco-and-their-disease-association,84371,0,2.html |
| _version_ | 1818757994632970240 |
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| author | Amit Kumar Deeksha Bhartiya Jasmine Kaur Suchitra Kumari Amitesh Sharma Harpreet Singh Dhirendra Sinha Ravi Mehrotra |
| author_facet | Amit Kumar Deeksha Bhartiya Jasmine Kaur Suchitra Kumari Amitesh Sharma Harpreet Singh Dhirendra Sinha Ravi Mehrotra |
| author_sort | Amit Kumar |
| collection | DOAJ |
| description | Background
Smokeless
tobacco (SLT) products are consumed by millions of people in over 130 countries
around the world. SLT products have a large impact on the health of individuals
since the products cause several diseases including cancer. Though the
smokeless tobacco products have been found to be associated with a large number
of health effects and diseases, the understanding of the functions of chemical
compounds of the products and their toxicity is very limited. There is a
complete lack of extensive analysis of the targets of the chemical compounds
and their associated biological mechanisms remain unknown.
Methods
One hundred and one chemical compounds of SLT
products were studied and similarity search algorithms were used to identify similar
compounds along with their protein targets using ChEMBL. The protein targets
were functionally annotated using PANTHER classification system and Kyoto
Encyclopedia of Genes and Genomes (KEGG) to identify the associated Gene
Ontologies and diseases respectively and the interaction network was studied.
In addition, pharmacological and toxicological
profiling ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) of chemicals were also studied.
Results
The study shows that the chemical compounds from
SLT products target more than 350 human proteins involved in a plethora of
human biological processes and affect around 100 pathways. The study has
identified associations of diseases such as neurodegenerative, immune and
cardiac diseases which were not known previously along with already established
diseases such as cancer.
Conclusions
We
provide the first comprehensive report and systematic analyses of 101 chemical
compounds from different SLT products used worldwide. The finding indicates
far-reaching impact of SLT products on human health than already known and this
finding needs further validations using epidemiological, in-vitro and in-vivo
methodologies. |
| first_indexed | 2024-12-18T06:19:47Z |
| format | Article |
| id | doaj.art-1786c83638804f528066776220847d44 |
| institution | Directory Open Access Journal |
| issn | 1617-9625 |
| language | English |
| last_indexed | 2024-12-18T06:19:47Z |
| publishDate | 2018-03-01 |
| publisher | European Publishing |
| record_format | Article |
| series | Tobacco Induced Diseases |
| spelling | doaj.art-1786c83638804f528066776220847d442022-12-21T21:18:10ZengEuropean PublishingTobacco Induced Diseases1617-96252018-03-0116110.18332/tid/8437184371Chemical profiling of smokeless tobacco and their disease associationAmit Kumar0Deeksha Bhartiya1Jasmine Kaur2Suchitra Kumari3Amitesh Sharma4Harpreet Singh5Dhirendra Sinha6Ravi Mehrotra7National Institute of Cancer Prevention and Research (NICPR), IndiaNational Institute of Cancer Prevention and Research (NICPR), IndiaIndian Council of Medical Research, IndiaNational Institute of Cancer Prevention and Research (NICPR), IndiaIndian Council of Medical Research, IndiaIndian Council of Medical Research, IndiaNational Institute of Cancer Prevention and Research (NICPR), IndiaNational Institute of Cancer Prevention and Research (NICPR), IndiaBackground Smokeless tobacco (SLT) products are consumed by millions of people in over 130 countries around the world. SLT products have a large impact on the health of individuals since the products cause several diseases including cancer. Though the smokeless tobacco products have been found to be associated with a large number of health effects and diseases, the understanding of the functions of chemical compounds of the products and their toxicity is very limited. There is a complete lack of extensive analysis of the targets of the chemical compounds and their associated biological mechanisms remain unknown. Methods One hundred and one chemical compounds of SLT products were studied and similarity search algorithms were used to identify similar compounds along with their protein targets using ChEMBL. The protein targets were functionally annotated using PANTHER classification system and Kyoto Encyclopedia of Genes and Genomes (KEGG) to identify the associated Gene Ontologies and diseases respectively and the interaction network was studied. In addition, pharmacological and toxicological profiling ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) of chemicals were also studied. Results The study shows that the chemical compounds from SLT products target more than 350 human proteins involved in a plethora of human biological processes and affect around 100 pathways. The study has identified associations of diseases such as neurodegenerative, immune and cardiac diseases which were not known previously along with already established diseases such as cancer. Conclusions We provide the first comprehensive report and systematic analyses of 101 chemical compounds from different SLT products used worldwide. The finding indicates far-reaching impact of SLT products on human health than already known and this finding needs further validations using epidemiological, in-vitro and in-vivo methodologies.http://www.journalssystem.com/tid/Chemical-profiling-of-smokeless-tobacco-and-their-disease-association,84371,0,2.htmlWCTOH |
| spellingShingle | Amit Kumar Deeksha Bhartiya Jasmine Kaur Suchitra Kumari Amitesh Sharma Harpreet Singh Dhirendra Sinha Ravi Mehrotra Chemical profiling of smokeless tobacco and their disease association Tobacco Induced Diseases WCTOH |
| title | Chemical profiling of smokeless tobacco and their disease association |
| title_full | Chemical profiling of smokeless tobacco and their disease association |
| title_fullStr | Chemical profiling of smokeless tobacco and their disease association |
| title_full_unstemmed | Chemical profiling of smokeless tobacco and their disease association |
| title_short | Chemical profiling of smokeless tobacco and their disease association |
| title_sort | chemical profiling of smokeless tobacco and their disease association |
| topic | WCTOH |
| url | http://www.journalssystem.com/tid/Chemical-profiling-of-smokeless-tobacco-and-their-disease-association,84371,0,2.html |
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