Pandemic Swine-Origin H1N1 Influenza Virus Replicates to Higher Levels and Induces More Fever and Acute Inflammatory Cytokines in Cynomolgus versus Rhesus Monkeys and Can Replicate in Common Marmosets.

Pandemic Swine-Origin H1N1 Influenza Virus Replicates to Higher Levels and Induces More Fever and Acute Inflammatory Cytokines in Cynomolgus versus Rhesus Monkeys and Can Replicate in Common Marmosets.

The close immunological and physiological resemblance with humans makes non-human primates a valuable model for studying influenza virus pathogenesis and immunity and vaccine efficacy against infection. Although both cynomolgus and rhesus macaques are frequently used in influenza virus research, a d...

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Bibliographic Details
Main Authors: Petra Mooij, Gerrit Koopman, Daniëlla Mortier, Melanie van Heteren, Herman Oostermeijer, Zahra Fagrouch, Rudy de Laat, Gary Kobinger, Yan Li, Edmond J Remarque, Ivanela Kondova, Ernst J Verschoor, Willy M J M Bogers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4422689?pdf=render

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