The Role Of IL-4 And IL-8 In The Itiology Of Tinea Versicolor In Group Of Iraqi Patients
Background: Tinea versicolor is a common dermatological problem ,world wide distribution , caused by a dimorphic fungus called Malassezia furfur ,it live normally on skin as a commensal . Many factors play a role in the etiology of TV among these could be the disturbed immune system which may be rel...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2007-04-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1429 |
| _version_ | 1797370197543223296 |
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| author | Wifaq M. AL-Wattar Nahla Ghanim Khalida M. Al-Moussawy Makrum M. Al-Waiz |
| author_facet | Wifaq M. AL-Wattar Nahla Ghanim Khalida M. Al-Moussawy Makrum M. Al-Waiz |
| author_sort | Wifaq M. AL-Wattar |
| collection | DOAJ |
| description | Background: Tinea versicolor is a common dermatological problem ,world wide distribution , caused by a dimorphic fungus called Malassezia furfur ,it live normally on skin as a commensal . Many factors play a role in the etiology of TV among these could be the disturbed immune system which may be related to the ability of TV alter the immune system by a process called Immunomodulation leading to subsequent infection. Immuno-inflammatory activity mediated by different cytokines could have a role in the etiology of TV.
Objective: To evaluate the serum level of the inflammatory cytokines ,IL-4andIL-8,in patients with TV as compared to immunocompramized patients and healthy groups.
Patients and methods: This study enrolled 50 total patients, 15 of them were as patients control group who were immunocompramized with evident skin lesion ,to be compared serologically with 15 patients who had TV and normal immunity, the control group composed of20 healthy volunteers. Using ELISA test technique the following tests were done :detection of IL-4 and IL-8 in the sera of all groups.
Results and discussion: The statistical differences in the rate of detectable IL-4 level between TV and healthy control p< 0.001,while the difference was a highly significant between the healthy control and immunocompramized patients with TV,P<0.00338.The difference between two diseased groups was(p< 0.219)which is non significant , when p<0. 05 was considered significant. IL-8 the results of our study showed a significant difference between the healthy control and the patients with tinea versicolor, p-value was( 0.05). In this study there was a nice findings by which the difference between the healthy control and the immunocompramized patients was highly significant as ,p<0.005.
Conclusion :The genus Malassezia is an immunological paradox. In some circumstances, it acts as an adjuvant, activates the complement cascade, and elicits both cellular and humoral immune responses in healthy individuals, among which IL8 and IL-4 were notably increased . In contrast, it also seems to have the ability not only to evade the immune system but actually to suppress the response directed against |
| first_indexed | 2024-03-08T17:57:56Z |
| format | Article |
| id | doaj.art-17891023f34f4df4878880e982c4c401 |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:57:56Z |
| publishDate | 2007-04-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-17891023f34f4df4878880e982c4c4012024-01-02T03:24:01ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572007-04-01491The Role Of IL-4 And IL-8 In The Itiology Of Tinea Versicolor In Group Of Iraqi PatientsWifaq M. AL-Wattar0Nahla Ghanim1Khalida M. Al-Moussawy2Makrum M. Al-Waiz3Dept. of Microbiology/College of medicine/ University of BaghdadImmunology/teaching laboratory/Health MinistryDept. of Microbiology/College of medicine/ University of BaghdadDept. of Dermatology / College of medicine/ University of BaghdadBackground: Tinea versicolor is a common dermatological problem ,world wide distribution , caused by a dimorphic fungus called Malassezia furfur ,it live normally on skin as a commensal . Many factors play a role in the etiology of TV among these could be the disturbed immune system which may be related to the ability of TV alter the immune system by a process called Immunomodulation leading to subsequent infection. Immuno-inflammatory activity mediated by different cytokines could have a role in the etiology of TV. Objective: To evaluate the serum level of the inflammatory cytokines ,IL-4andIL-8,in patients with TV as compared to immunocompramized patients and healthy groups. Patients and methods: This study enrolled 50 total patients, 15 of them were as patients control group who were immunocompramized with evident skin lesion ,to be compared serologically with 15 patients who had TV and normal immunity, the control group composed of20 healthy volunteers. Using ELISA test technique the following tests were done :detection of IL-4 and IL-8 in the sera of all groups. Results and discussion: The statistical differences in the rate of detectable IL-4 level between TV and healthy control p< 0.001,while the difference was a highly significant between the healthy control and immunocompramized patients with TV,P<0.00338.The difference between two diseased groups was(p< 0.219)which is non significant , when p<0. 05 was considered significant. IL-8 the results of our study showed a significant difference between the healthy control and the patients with tinea versicolor, p-value was( 0.05). In this study there was a nice findings by which the difference between the healthy control and the immunocompramized patients was highly significant as ,p<0.005. Conclusion :The genus Malassezia is an immunological paradox. In some circumstances, it acts as an adjuvant, activates the complement cascade, and elicits both cellular and humoral immune responses in healthy individuals, among which IL8 and IL-4 were notably increased . In contrast, it also seems to have the ability not only to evade the immune system but actually to suppress the response directed againsthttp://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1429( IL-4,IL-8,Tineaversicolor ,Iraqi patients). |
| spellingShingle | Wifaq M. AL-Wattar Nahla Ghanim Khalida M. Al-Moussawy Makrum M. Al-Waiz The Role Of IL-4 And IL-8 In The Itiology Of Tinea Versicolor In Group Of Iraqi Patients مجلة كلية الطب ( IL-4,IL-8,Tineaversicolor ,Iraqi patients). |
| title | The Role Of IL-4 And IL-8 In The Itiology Of Tinea Versicolor In Group Of Iraqi Patients |
| title_full | The Role Of IL-4 And IL-8 In The Itiology Of Tinea Versicolor In Group Of Iraqi Patients |
| title_fullStr | The Role Of IL-4 And IL-8 In The Itiology Of Tinea Versicolor In Group Of Iraqi Patients |
| title_full_unstemmed | The Role Of IL-4 And IL-8 In The Itiology Of Tinea Versicolor In Group Of Iraqi Patients |
| title_short | The Role Of IL-4 And IL-8 In The Itiology Of Tinea Versicolor In Group Of Iraqi Patients |
| title_sort | role of il 4 and il 8 in the itiology of tinea versicolor in group of iraqi patients |
| topic | ( IL-4,IL-8,Tineaversicolor ,Iraqi patients). |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1429 |
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